KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EDG-1
Full Name:
Sphingosine 1-phosphate receptor 1
Alias:
D1S3362; EDG1; Edg-1; Endothelial differentiation G-protein coupled receptor 1; Probable G protein-coupled receptor EDG-1; Sphingosine 1-phosphate receptor Edg-1; Sphingosine-1-phosphate receptor 1
Type:
G protein-coupled 7TM receptor
Mass (Da):
42811
Number AA:
382
UniProt ID:
P21453
International Prot ID:
IPI00015343
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0001619
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
L
V
K
A
H
R
S
S
V
S
D
Y
V
N
Y
Site 2
S17
K
A
H
R
S
S
V
S
D
Y
V
N
Y
D
I
Site 3
Y19
H
R
S
S
V
S
D
Y
V
N
Y
D
I
I
V
Site 4
Y22
S
V
S
D
Y
V
N
Y
D
I
I
V
R
H
Y
Site 5
Y29
Y
D
I
I
V
R
H
Y
N
Y
T
G
K
L
N
Site 6
T32
I
V
R
H
Y
N
Y
T
G
K
L
N
I
S
A
Site 7
Y81
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
Site 8
T113
G
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
Site 9
S226
I
L
Y
C
R
I
Y
S
L
V
R
T
R
S
R
Site 10
T230
R
I
Y
S
L
V
R
T
R
S
R
R
L
T
F
Site 11
S232
Y
S
L
V
R
T
R
S
R
R
L
T
F
R
K
Site 12
T236
R
T
R
S
R
R
L
T
F
R
K
N
I
S
K
Site 13
S242
L
T
F
R
K
N
I
S
K
A
S
R
S
S
E
Site 14
S245
R
K
N
I
S
K
A
S
R
S
S
E
K
S
L
Site 15
S247
N
I
S
K
A
S
R
S
S
E
K
S
L
A
L
Site 16
S248
I
S
K
A
S
R
S
S
E
K
S
L
A
L
L
Site 17
S251
A
S
R
S
S
E
K
S
L
A
L
L
K
T
V
Site 18
Y311
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
Site 19
S351
I
I
A
G
M
E
F
S
R
S
K
S
D
N
S
Site 20
S353
A
G
M
E
F
S
R
S
K
S
D
N
S
S
H
Site 21
S355
M
E
F
S
R
S
K
S
D
N
S
S
H
P
Q
Site 22
S358
S
R
S
K
S
D
N
S
S
H
P
Q
K
D
E
Site 23
S359
R
S
K
S
D
N
S
S
H
P
Q
K
D
E
G
Site 24
T371
D
E
G
D
N
P
E
T
I
M
S
S
G
N
V
Site 25
S374
D
N
P
E
T
I
M
S
S
G
N
V
N
S
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation