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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TNFAIP3
Full Name:
Tumor necrosis factor alpha-induced protein 3
Alias:
A20; DNA binding protein A20; EC 3.-.-.-; OTUD7C; TNAP3; TNFA1P2; Zinc finger protein A20
Type:
EC 3.-.-.-; Inhibitor protein; Protease
Mass (Da):
89614
Number AA:
790
UniProt ID:
P21580
International Prot ID:
IPI00009448
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008234
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
Q
V
L
P
Q
A
L
Y
L
S
N
M
R
K
A
Site 2
S13
L
P
Q
A
L
Y
L
S
N
M
R
K
A
V
K
Site 3
T25
A
V
K
I
R
E
R
T
P
E
D
I
F
K
P
Site 4
T47
F
K
T
M
H
R
Y
T
L
E
M
F
R
T
C
Site 5
T76
I
D
R
N
I
Q
A
T
L
E
S
Q
K
K
L
Site 6
T97
R
K
L
V
A
L
K
T
N
G
D
G
N
C
L
Site 7
Y111
L
M
H
A
T
S
Q
Y
M
W
G
V
Q
D
T
Site 8
S128
V
L
R
K
A
L
F
S
T
L
K
E
T
D
T
Site 9
T135
S
T
L
K
E
T
D
T
R
N
F
K
F
R
W
Site 10
S146
K
F
R
W
Q
L
E
S
L
K
S
Q
E
F
V
Site 11
S149
W
Q
L
E
S
L
K
S
Q
E
F
V
E
T
G
Site 12
T155
K
S
Q
E
F
V
E
T
G
L
C
Y
D
T
R
Site 13
Y159
F
V
E
T
G
L
C
Y
D
T
R
N
W
N
D
Site 14
S176
D
N
L
I
K
M
A
S
T
D
T
P
M
A
R
Site 15
T179
I
K
M
A
S
T
D
T
P
M
A
R
S
G
L
Site 16
Y188
M
A
R
S
G
L
Q
Y
N
S
L
E
E
I
H
Site 17
S190
R
S
G
L
Q
Y
N
S
L
E
E
I
H
I
F
Site 18
S217
I
S
D
K
M
L
R
S
L
E
S
G
S
N
F
Site 19
S220
K
M
L
R
S
L
E
S
G
S
N
F
A
P
L
Site 20
S222
L
R
S
L
E
S
G
S
N
F
A
P
L
K
V
Site 21
Y244
H
W
P
A
Q
E
C
Y
R
Y
P
I
V
L
G
Site 22
Y246
P
A
Q
E
C
Y
R
Y
P
I
V
L
G
Y
D
Site 23
Y252
R
Y
P
I
V
L
G
Y
D
S
H
H
F
V
P
Site 24
T262
H
H
F
V
P
L
V
T
L
K
D
S
G
P
E
Site 25
Y345
E
I
N
L
V
D
D
Y
F
E
L
V
Q
H
E
Site 26
S360
Y
K
K
W
Q
E
N
S
E
Q
G
R
R
E
G
Site 27
S376
A
Q
N
P
M
E
P
S
V
P
Q
L
S
L
M
Site 28
S381
E
P
S
V
P
Q
L
S
L
M
D
V
K
C
E
Site 29
S423
N
K
L
P
K
L
N
S
K
P
G
P
E
G
L
Site 30
Y443
G
A
S
R
G
E
A
Y
E
P
L
A
W
N
P
Site 31
T454
A
W
N
P
E
E
S
T
G
G
P
H
S
A
P
Site 32
S459
E
S
T
G
G
P
H
S
A
P
P
T
A
P
S
Site 33
T463
G
P
H
S
A
P
P
T
A
P
S
P
F
L
F
Site 34
S466
S
A
P
P
T
A
P
S
P
F
L
F
S
E
T
Site 35
S480
T
T
A
M
K
C
R
S
P
G
C
P
F
T
L
Site 36
T486
R
S
P
G
C
P
F
T
L
N
V
Q
H
N
G
Site 37
S507
N
A
R
Q
L
H
A
S
H
A
P
D
H
T
R
Site 38
T513
A
S
H
A
P
D
H
T
R
H
L
D
P
G
K
Site 39
T544
S
T
C
F
K
R
T
T
A
E
A
S
S
S
L
Site 40
S548
K
R
T
T
A
E
A
S
S
S
L
S
T
S
L
Site 41
S550
T
T
A
E
A
S
S
S
L
S
T
S
L
P
P
Site 42
S552
A
E
A
S
S
S
L
S
T
S
L
P
P
S
C
Site 43
T553
E
A
S
S
S
L
S
T
S
L
P
P
S
C
H
Site 44
S554
A
S
S
S
L
S
T
S
L
P
P
S
C
H
Q
Site 45
S558
L
S
T
S
L
P
P
S
C
H
Q
R
S
K
S
Site 46
S563
P
P
S
C
H
Q
R
S
K
S
D
P
S
R
L
Site 47
S565
S
C
H
Q
R
S
K
S
D
P
S
R
L
V
R
Site 48
S568
Q
R
S
K
S
D
P
S
R
L
V
R
S
P
S
Site 49
S573
D
P
S
R
L
V
R
S
P
S
P
H
S
C
H
Site 50
S575
S
R
L
V
R
S
P
S
P
H
S
C
H
R
A
Site 51
S578
V
R
S
P
S
P
H
S
C
H
R
A
G
N
D
Site 52
S592
D
A
P
A
G
C
L
S
Q
A
A
R
T
P
G
Site 53
T597
C
L
S
Q
A
A
R
T
P
G
D
R
T
G
T
Site 54
T602
A
R
T
P
G
D
R
T
G
T
S
K
C
R
K
Site 55
T604
T
P
G
D
R
T
G
T
S
K
C
R
K
A
G
Site 56
S605
P
G
D
R
T
G
T
S
K
C
R
K
A
G
C
Site 57
Y614
C
R
K
A
G
C
V
Y
F
G
T
P
E
N
K
Site 58
T617
A
G
C
V
Y
F
G
T
P
E
N
K
G
F
C
Site 59
Y631
C
T
L
C
F
I
E
Y
R
E
N
K
H
F
A
Site 60
S641
N
K
H
F
A
A
A
S
G
K
V
S
P
T
A
Site 61
S645
A
A
A
S
G
K
V
S
P
T
A
S
R
F
Q
Site 62
T647
A
S
G
K
V
S
P
T
A
S
R
F
Q
N
T
Site 63
S649
G
K
V
S
P
T
A
S
R
F
Q
N
T
I
P
Site 64
Y673
G
S
T
M
F
E
G
Y
C
Q
K
C
F
I
E
Site 65
T692
R
F
H
E
A
K
R
T
E
E
Q
L
R
S
S
Site 66
S698
R
T
E
E
Q
L
R
S
S
Q
R
R
D
V
P
Site 67
S699
T
E
E
Q
L
R
S
S
Q
R
R
D
V
P
R
Site 68
T707
Q
R
R
D
V
P
R
T
T
Q
S
T
S
R
P
Site 69
T708
R
R
D
V
P
R
T
T
Q
S
T
S
R
P
K
Site 70
S710
D
V
P
R
T
T
Q
S
T
S
R
P
K
C
A
Site 71
T711
V
P
R
T
T
Q
S
T
S
R
P
K
C
A
R
Site 72
S712
P
R
T
T
Q
S
T
S
R
P
K
C
A
R
A
Site 73
Y778
G
N
A
K
C
N
G
Y
C
N
E
C
F
Q
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation