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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NT5E
Full Name:
5'-nucleotidase
Alias:
Ecto-5'-nucleotidase
Type:
Mass (Da):
63368
Number AA:
574
UniProt ID:
P21589
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
Site 2
T44
V
H
S
R
L
E
Q
T
S
E
D
S
S
K
C
Site 3
S45
H
S
R
L
E
Q
T
S
E
D
S
S
K
C
V
Site 4
S49
E
Q
T
S
E
D
S
S
K
C
V
N
A
S
R
Site 5
T66
G
G
V
A
R
L
F
T
K
V
Q
Q
I
R
R
Site 6
Y87
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
Site 7
Y110
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
Site 8
S141
E
A
K
F
P
I
L
S
A
N
I
K
A
K
G
Site 9
S152
K
A
K
G
P
L
A
S
Q
I
S
G
L
Y
L
Site 10
S155
G
P
L
A
S
Q
I
S
G
L
Y
L
P
Y
K
Site 11
Y158
A
S
Q
I
S
G
L
Y
L
P
Y
K
V
L
P
Site 12
T181
V
G
Y
T
S
K
E
T
P
F
L
S
N
P
G
Site 13
S185
S
K
E
T
P
F
L
S
N
P
G
T
N
L
V
Site 14
T189
P
F
L
S
N
P
G
T
N
L
V
F
E
D
E
Site 15
T209
P
E
V
D
K
L
K
T
L
N
V
N
K
I
I
Site 16
T246
V
V
G
G
H
S
N
T
F
L
Y
T
G
N
P
Site 17
Y249
G
H
S
N
T
F
L
Y
T
G
N
P
P
S
K
Site 18
S255
L
Y
T
G
N
P
P
S
K
E
V
P
A
G
K
Site 19
Y263
K
E
V
P
A
G
K
Y
P
F
I
V
T
S
D
Site 20
S269
K
Y
P
F
I
V
T
S
D
D
G
R
K
V
P
Site 21
Y289
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
Site 22
S302
D
E
R
G
N
V
I
S
S
H
G
N
P
I
L
Site 23
S312
G
N
P
I
L
L
N
S
S
I
P
E
D
P
S
Site 24
S313
N
P
I
L
L
N
S
S
I
P
E
D
P
S
I
Site 25
S319
S
S
I
P
E
D
P
S
I
K
A
D
I
N
K
Site 26
Y334
W
R
I
K
L
D
N
Y
S
T
Q
E
L
G
K
Site 27
S335
R
I
K
L
D
N
Y
S
T
Q
E
L
G
K
T
Site 28
T342
S
T
Q
E
L
G
K
T
I
V
Y
L
D
G
S
Site 29
Y345
E
L
G
K
T
I
V
Y
L
D
G
S
S
Q
S
Site 30
S350
I
V
Y
L
D
G
S
S
Q
S
C
R
F
R
E
Site 31
S352
Y
L
D
G
S
S
Q
S
C
R
F
R
E
C
N
Site 32
S396
L
N
G
G
G
I
R
S
P
I
D
E
R
N
N
Site 33
S438
L
K
K
A
F
E
H
S
V
H
R
Y
G
Q
S
Site 34
Y442
F
E
H
S
V
H
R
Y
G
Q
S
T
G
E
F
Site 35
S445
S
V
H
R
Y
G
Q
S
T
G
E
F
L
Q
V
Site 36
T446
V
H
R
Y
G
Q
S
T
G
E
F
L
Q
V
G
Site 37
Y459
V
G
G
I
H
V
V
Y
D
L
S
R
K
P
G
Site 38
S462
I
H
V
V
Y
D
L
S
R
K
P
G
D
R
V
Site 39
S483
C
T
K
C
R
V
P
S
Y
D
P
L
K
M
D
Site 40
Y484
T
K
C
R
V
P
S
Y
D
P
L
K
M
D
E
Site 41
S520
D
E
L
L
R
H
D
S
G
D
Q
D
I
N
V
Site 42
S549
V
E
G
R
I
K
F
S
T
G
S
H
C
H
G
Site 43
T550
E
G
R
I
K
F
S
T
G
S
H
C
H
G
S
Site 44
S552
R
I
K
F
S
T
G
S
H
C
H
G
S
F
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation