KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Kv1.3
Full Name:
Potassium voltage-gated channel subfamily A member 3
Alias:
CIK3; HGK5; HLK3; HPCN3; HuKIII; KCNA3; MK3; Potassium channel Kv1.3; potassium voltage-gated channel, shaker-related subfamily, member 3
Type:
Channel protein, potassium
Mass (Da):
63842
Number AA:
575
UniProt ID:
P22001
International Prot ID:
IPI00217447
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0008076
Uniprot
OncoNet
Molecular Function:
GO:0005251
GO:0030955
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
E
R
L
S
L
L
R
S
P
P
P
Site 2
S10
E
R
L
S
L
L
R
S
P
P
P
P
S
A
R
Site 3
S15
L
R
S
P
P
P
P
S
A
R
H
R
A
H
P
Site 4
S28
H
P
P
Q
R
P
A
S
S
G
G
A
H
T
L
Site 5
T34
A
S
S
G
G
A
H
T
L
V
N
H
G
Y
A
Site 6
Y40
H
T
L
V
N
H
G
Y
A
E
P
A
A
G
R
Site 7
T54
R
E
L
P
P
D
M
T
V
V
P
G
D
H
L
Site 8
Y86
G
G
G
G
C
D
R
Y
E
P
L
P
P
S
L
Site 9
S92
R
Y
E
P
L
P
P
S
L
P
A
A
G
E
Q
Site 10
S111
E
R
V
V
I
N
I
S
G
L
R
F
E
T
Q
Site 11
T117
I
S
G
L
R
F
E
T
Q
L
K
T
L
C
Q
Site 12
T121
R
F
E
T
Q
L
K
T
L
C
Q
F
P
E
T
Site 13
T128
T
L
C
Q
F
P
E
T
L
L
G
D
P
K
R
Site 14
Y139
D
P
K
R
R
M
R
Y
F
D
P
L
R
N
E
Site 15
Y147
F
D
P
L
R
N
E
Y
F
F
D
R
N
R
P
Site 16
S155
F
F
D
R
N
R
P
S
F
D
A
I
L
Y
Y
Site 17
Y161
P
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
Site 18
Y162
S
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
I
Site 19
Y163
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
I
R
Site 20
S165
A
I
L
Y
Y
Y
Q
S
G
G
R
I
R
R
P
Site 21
Y187
F
S
E
E
I
R
F
Y
Q
L
G
E
E
A
M
Site 22
Y226
Q
V
W
L
L
F
E
Y
P
E
S
S
G
P
A
Site 23
S229
L
L
F
E
Y
P
E
S
S
G
P
A
R
G
I
Site 24
Y265
E
F
R
D
E
K
D
Y
P
A
S
T
S
Q
D
Site 25
S268
D
E
K
D
Y
P
A
S
T
S
Q
D
S
F
E
Site 26
S270
K
D
Y
P
A
S
T
S
Q
D
S
F
E
A
A
Site 27
S273
P
A
S
T
S
Q
D
S
F
E
A
A
G
N
S
Site 28
S280
S
F
E
A
A
G
N
S
T
S
G
S
R
A
G
Site 29
S282
E
A
A
G
N
S
T
S
G
S
R
A
G
A
S
Site 30
S284
A
G
N
S
T
S
G
S
R
A
G
A
S
S
F
Site 31
S289
S
G
S
R
A
G
A
S
S
F
S
D
P
F
F
Site 32
S290
G
S
R
A
G
A
S
S
F
S
D
P
F
F
V
Site 33
S319
V
R
F
F
A
C
P
S
K
A
T
F
S
R
N
Site 34
S378
V
F
R
I
F
K
L
S
R
H
S
K
G
L
Q
Site 35
S381
I
F
K
L
S
R
H
S
K
G
L
Q
I
L
G
Site 36
T425
F
A
E
A
D
D
P
T
S
G
F
S
S
I
P
Site 37
S426
A
E
A
D
D
P
T
S
G
F
S
S
I
P
D
Site 38
S430
D
P
T
S
G
F
S
S
I
P
D
A
F
W
W
Site 39
Y447
E
G
E
E
Q
S
Q
Y
M
H
V
G
S
C
Q
Site 40
S462
I
G
G
K
I
V
G
S
L
C
A
I
A
G
V
Site 41
Y485
V
I
V
S
N
F
N
Y
F
Y
H
R
E
T
E
Site 42
Y487
V
S
N
F
N
Y
F
Y
H
R
E
T
E
G
E
Site 43
T491
N
Y
F
Y
H
R
E
T
E
G
E
E
Q
S
Q
Site 44
S497
E
T
E
G
E
E
Q
S
Q
Y
M
H
V
G
S
Site 45
Y499
E
G
E
E
Q
S
Q
Y
M
H
V
G
S
C
Q
Site 46
S504
S
Q
Y
M
H
V
G
S
C
Q
H
L
S
S
S
Site 47
S509
V
G
S
C
Q
H
L
S
S
S
A
E
E
L
R
Site 48
S510
G
S
C
Q
H
L
S
S
S
A
E
E
L
R
K
Site 49
S511
S
C
Q
H
L
S
S
S
A
E
E
L
R
K
A
Site 50
S520
E
E
L
R
K
A
R
S
N
S
T
L
S
K
S
Site 51
S522
L
R
K
A
R
S
N
S
T
L
S
K
S
E
Y
Site 52
T523
R
K
A
R
S
N
S
T
L
S
K
S
E
Y
M
Site 53
S525
A
R
S
N
S
T
L
S
K
S
E
Y
M
V
I
Site 54
S527
S
N
S
T
L
S
K
S
E
Y
M
V
I
E
E
Site 55
Y529
S
T
L
S
K
S
E
Y
M
V
I
E
E
G
G
Site 56
S540
E
E
G
G
M
N
H
S
A
F
P
Q
T
P
F
Site 57
T545
N
H
S
A
F
P
Q
T
P
F
K
T
G
N
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation