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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSBP
Full Name:
Oxysterol-binding protein 1
Alias:
OSB1; OSBP1; oxysterol binding protein
Type:
Lipid binding protein
Mass (Da):
89421
Number AA:
807
UniProt ID:
P22059
International Prot ID:
IPI00024971
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008142
PhosphoSite+
KinaseNET
Biological Process:
GO:0006869
GO:0008202
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
A
A
T
E
L
R
G
V
V
G
Site 2
S43
R
G
D
A
G
P
G
S
G
A
A
S
G
T
V
Site 3
T76
G
P
A
P
A
P
P
T
G
G
S
G
G
S
G
Site 4
S79
P
A
P
P
T
G
G
S
G
G
S
G
A
G
G
Site 5
S82
P
T
G
G
S
G
G
S
G
A
G
G
S
G
S
Site 6
S87
G
G
S
G
A
G
G
S
G
S
A
R
E
G
W
Site 7
S89
S
G
A
G
G
S
G
S
A
R
E
G
W
L
F
Site 8
S113
Q
R
R
W
F
V
L
S
N
G
L
L
S
Y
Y
Site 9
S118
V
L
S
N
G
L
L
S
Y
Y
R
S
K
A
E
Site 10
Y119
L
S
N
G
L
L
S
Y
Y
R
S
K
A
E
M
Site 11
Y120
S
N
G
L
L
S
Y
Y
R
S
K
A
E
M
R
Site 12
S122
G
L
L
S
Y
Y
R
S
K
A
E
M
R
H
T
Site 13
T129
S
K
A
E
M
R
H
T
C
R
G
T
I
N
L
Site 14
T133
M
R
H
T
C
R
G
T
I
N
L
A
T
A
N
Site 15
Y159
S
N
G
G
A
Q
T
Y
H
L
K
A
S
S
E
Site 16
T174
V
E
R
Q
R
W
V
T
A
L
E
L
A
K
A
Site 17
S190
A
V
K
M
L
A
E
S
D
E
S
G
D
E
E
Site 18
S193
M
L
A
E
S
D
E
S
G
D
E
E
S
V
S
Site 19
S198
D
E
S
G
D
E
E
S
V
S
Q
T
D
K
T
Site 20
S200
S
G
D
E
E
S
V
S
Q
T
D
K
T
E
L
Site 21
T202
D
E
E
S
V
S
Q
T
D
K
T
E
L
Q
N
Site 22
T205
S
V
S
Q
T
D
K
T
E
L
Q
N
T
L
R
Site 23
T210
D
K
T
E
L
Q
N
T
L
R
T
L
S
S
K
Site 24
T213
E
L
Q
N
T
L
R
T
L
S
S
K
V
E
D
Site 25
S215
Q
N
T
L
R
T
L
S
S
K
V
E
D
L
S
Site 26
S216
N
T
L
R
T
L
S
S
K
V
E
D
L
S
T
Site 27
S222
S
S
K
V
E
D
L
S
T
C
N
D
L
I
A
Site 28
T223
S
K
V
E
D
L
S
T
C
N
D
L
I
A
K
Site 29
T233
D
L
I
A
K
H
G
T
A
L
Q
R
S
L
S
Site 30
S238
H
G
T
A
L
Q
R
S
L
S
E
L
E
S
L
Site 31
S240
T
A
L
Q
R
S
L
S
E
L
E
S
L
K
L
Site 32
S244
R
S
L
S
E
L
E
S
L
K
L
P
A
E
S
Site 33
T263
K
Q
V
N
E
R
A
T
L
F
R
I
T
S
N
Site 34
T285
D
F
L
M
L
A
Q
T
H
S
K
K
W
Q
K
Site 35
S287
L
M
L
A
Q
T
H
S
K
K
W
Q
K
S
L
Site 36
S293
H
S
K
K
W
Q
K
S
L
Q
Y
E
R
D
Q
Site 37
Y296
K
W
Q
K
S
L
Q
Y
E
R
D
Q
R
I
R
Site 38
T326
E
R
A
F
R
G
A
T
V
L
P
A
N
T
P
Site 39
S338
N
T
P
G
N
V
G
S
G
K
D
Q
C
C
S
Site 40
S345
S
G
K
D
Q
C
C
S
G
K
G
D
M
S
D
Site 41
S351
C
S
G
K
G
D
M
S
D
E
D
D
E
N
E
Site 42
T377
E
N
L
G
H
K
R
T
G
S
N
I
S
G
A
Site 43
S379
L
G
H
K
R
T
G
S
N
I
S
G
A
S
S
Site 44
S382
K
R
T
G
S
N
I
S
G
A
S
S
D
I
S
Site 45
S385
G
S
N
I
S
G
A
S
S
D
I
S
L
D
E
Site 46
S386
S
N
I
S
G
A
S
S
D
I
S
L
D
E
Q
Site 47
S389
S
G
A
S
S
D
I
S
L
D
E
Q
Y
K
H
Site 48
Y394
D
I
S
L
D
E
Q
Y
K
H
Q
L
E
E
T
Site 49
Y411
E
K
R
T
R
I
P
Y
K
P
N
Y
S
L
N
Site 50
Y415
R
I
P
Y
K
P
N
Y
S
L
N
L
W
S
I
Site 51
S432
N
C
I
G
K
E
L
S
K
I
P
M
P
V
N
Site 52
S445
V
N
F
N
E
P
L
S
M
L
Q
R
L
T
E
Site 53
T451
L
S
M
L
Q
R
L
T
E
D
L
E
Y
H
E
Site 54
Y456
R
L
T
E
D
L
E
Y
H
E
L
L
D
R
A
Site 55
S469
R
A
A
K
C
E
N
S
L
E
Q
L
C
Y
V
Site 56
T486
F
T
V
S
S
Y
S
T
T
V
F
R
T
S
K
Site 57
T487
T
V
S
S
Y
S
T
T
V
F
R
T
S
K
P
Site 58
S492
S
T
T
V
F
R
T
S
K
P
F
N
P
L
L
Site 59
Y513
D
R
L
E
E
N
G
Y
R
S
L
C
E
Q
V
Site 60
S515
L
E
E
N
G
Y
R
S
L
C
E
Q
V
S
H
Site 61
S521
R
S
L
C
E
Q
V
S
H
H
P
P
A
A
A
Site 62
T546
L
R
Q
E
I
K
I
T
S
K
F
R
G
K
Y
Site 63
Y553
T
S
K
F
R
G
K
Y
L
S
I
M
P
L
G
Site 64
T561
L
S
I
M
P
L
G
T
I
H
C
I
F
H
A
Site 65
Y573
F
H
A
T
G
H
H
Y
T
W
K
K
V
T
T
Site 66
S595
G
K
L
W
I
D
Q
S
G
E
I
D
I
V
N
Site 67
S617
N
L
K
F
V
P
Y
S
Y
F
S
R
D
V
A
Site 68
Y618
L
K
F
V
P
Y
S
Y
F
S
R
D
V
A
R
Site 69
T628
R
D
V
A
R
K
V
T
G
E
V
T
D
P
S
Site 70
S635
T
G
E
V
T
D
P
S
G
K
V
H
F
A
L
Site 71
T645
V
H
F
A
L
L
G
T
W
D
E
K
M
E
C
Site 72
S676
R
G
H
E
A
E
E
S
R
V
M
L
W
K
R
Site 73
Y694
P
K
N
A
E
N
M
Y
Y
F
S
E
L
A
L
Site 74
Y695
K
N
A
E
N
M
Y
Y
F
S
E
L
A
L
T
Site 75
S708
L
T
L
N
A
W
E
S
G
T
A
P
T
D
S
Site 76
S715
S
G
T
A
P
T
D
S
R
L
R
P
D
Q
R
Site 77
S746
L
E
E
K
Q
R
L
S
R
K
K
R
E
A
E
Site 78
T762
M
K
A
T
E
D
G
T
P
Y
D
P
Y
K
A
Site 79
Y764
A
T
E
D
G
T
P
Y
D
P
Y
K
A
L
W
Site 80
Y767
D
G
T
P
Y
D
P
Y
K
A
L
W
F
E
R
Site 81
T780
E
R
K
K
D
P
V
T
K
E
L
T
H
I
Y
Site 82
Y791
T
H
I
Y
R
G
E
Y
W
E
C
K
E
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation