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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AChE
Full Name:
Acetylcholinesterase
Alias:
ACES; Acetylcholinesterase (Yt blood group); ARACHE; EC 3.1.1.7; N-ACHE; YT
Type:
Lipid Metabolism - glycerophospholipid; EC 3.1.1.7; Hydrolase
Mass (Da):
67796
Number AA:
614
UniProt ID:
P22303
International Prot ID:
IPI00026103
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0031225
GO:0005605
Uniprot
OncoNet
Molecular Function:
GO:0042166
GO:0003990
GO:0001540
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0001507
GO:0042982
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T42
E
D
A
E
L
L
V
T
V
R
G
G
R
L
R
Site 2
T55
L
R
G
I
R
L
K
T
P
G
G
P
V
S
A
Site 3
S88
P
E
P
K
Q
P
W
S
G
V
V
D
A
T
T
Site 4
Y101
T
T
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
Site 5
Y103
F
Q
S
V
C
Y
Q
Y
V
D
T
L
Y
P
G
Site 6
Y108
Y
Q
Y
V
D
T
L
Y
P
G
F
E
G
T
E
Site 7
Y129
E
L
S
E
D
C
L
Y
L
N
V
W
T
P
Y
Site 8
T134
C
L
Y
L
N
V
W
T
P
Y
P
R
P
T
S
Site 9
Y136
Y
L
N
V
W
T
P
Y
P
R
P
T
S
P
T
Site 10
T140
W
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
Site 11
S141
T
P
Y
P
R
P
T
S
P
T
P
V
L
V
W
Site 12
T143
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
Site 13
S160
G
F
Y
S
G
A
S
S
L
D
V
Y
D
G
R
Site 14
Y164
G
A
S
S
L
D
V
Y
D
G
R
F
L
V
Q
Site 15
T229
G
G
D
P
T
S
V
T
L
F
G
E
S
A
G
Site 16
S249
M
H
L
L
S
P
P
S
R
G
L
F
H
R
A
Site 17
S260
F
H
R
A
V
L
Q
S
G
A
P
N
G
P
W
Site 18
T269
A
P
N
G
P
W
A
T
V
G
M
G
E
A
R
Site 19
T280
G
E
A
R
R
R
A
T
Q
L
A
H
L
V
G
Site 20
T298
G
G
T
G
G
N
D
T
E
L
V
A
C
L
R
Site 21
T342
D
G
D
F
L
S
D
T
P
E
A
L
I
N
A
Site 22
Y372
E
G
S
Y
F
L
V
Y
G
A
P
G
F
S
K
Site 23
S378
V
Y
G
A
P
G
F
S
K
D
N
E
S
L
I
Site 24
S383
G
F
S
K
D
N
E
S
L
I
S
R
A
E
F
Site 25
S386
K
D
N
E
S
L
I
S
R
A
E
F
L
A
G
Site 26
S430
A
R
L
R
E
A
L
S
D
V
V
G
D
H
N
Site 27
Y457
A
A
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
Site 28
Y459
Q
G
A
R
V
Y
A
Y
V
F
E
H
R
A
S
Site 29
T467
V
F
E
H
R
A
S
T
L
S
W
P
L
W
M
Site 30
S469
E
H
R
A
S
T
L
S
W
P
L
W
M
G
V
Site 31
S493
F
G
I
P
L
D
P
S
R
N
Y
T
A
E
E
Site 32
Y496
P
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
Site 33
T497
L
D
P
S
R
N
Y
T
A
E
E
K
I
F
A
Site 34
Y510
F
A
Q
R
L
M
R
Y
W
A
N
F
A
R
T
Site 35
Y534
K
A
P
Q
W
P
P
Y
T
A
G
A
Q
Q
Y
Site 36
Y541
Y
T
A
G
A
Q
Q
Y
V
S
L
D
L
R
P
Site 37
S543
A
G
A
Q
Q
Y
V
S
L
D
L
R
P
L
E
Site 38
S572
R
F
L
P
K
L
L
S
A
T
D
T
L
D
E
Site 39
T576
K
L
L
S
A
T
D
T
L
D
E
A
E
R
Q
Site 40
Y605
W
K
N
Q
F
D
H
Y
S
K
Q
D
R
C
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation