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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IDS
Full Name:
Iduronate 2-sulfatase
Alias:
Alpha-L-iduronate sulfate sulfatase; EC 3.1.6.13; MPS2; SIDS
Type:
Enzyme, sulphatase
Mass (Da):
61873
Number AA:
550
UniProt ID:
P22304
International Prot ID:
IPI00026104
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004423
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
P
P
P
R
T
G
R
G
L
L
W
L
Site 2
T28
C
V
A
L
G
S
E
T
Q
A
N
S
T
T
D
Site 3
S32
G
S
E
T
Q
A
N
S
T
T
D
A
L
N
V
Site 4
S50
I
V
D
D
L
R
P
S
L
G
C
Y
G
D
K
Site 5
Y54
L
R
P
S
L
G
C
Y
G
D
K
L
V
R
S
Site 6
S61
Y
G
D
K
L
V
R
S
P
N
I
D
Q
L
A
Site 7
S90
V
C
A
P
S
R
V
S
F
L
T
G
R
R
P
Site 8
T93
P
S
R
V
S
F
L
T
G
R
R
P
D
T
T
Site 9
T99
L
T
G
R
R
P
D
T
T
R
L
Y
D
F
N
Site 10
T100
T
G
R
R
P
D
T
T
R
L
Y
D
F
N
S
Site 11
Y103
R
P
D
T
T
R
L
Y
D
F
N
S
Y
W
R
Site 12
Y108
R
L
Y
D
F
N
S
Y
W
R
V
H
A
G
N
Site 13
Y122
N
F
S
T
I
P
Q
Y
F
K
E
N
G
Y
V
Site 14
Y128
Q
Y
F
K
E
N
G
Y
V
T
M
S
V
G
K
Site 15
T146
P
G
I
S
S
N
H
T
D
D
S
P
Y
S
W
Site 16
S149
S
S
N
H
T
D
D
S
P
Y
S
W
S
F
P
Site 17
Y151
N
H
T
D
D
S
P
Y
S
W
S
F
P
P
Y
Site 18
S154
D
D
S
P
Y
S
W
S
F
P
P
Y
H
P
S
Site 19
Y158
Y
S
W
S
F
P
P
Y
H
P
S
S
E
K
Y
Site 20
S161
S
F
P
P
Y
H
P
S
S
E
K
Y
E
N
T
Site 21
S162
F
P
P
Y
H
P
S
S
E
K
Y
E
N
T
K
Site 22
Y165
Y
H
P
S
S
E
K
Y
E
N
T
K
T
C
R
Site 23
T170
E
K
Y
E
N
T
K
T
C
R
G
P
D
G
E
Site 24
S201
G
T
L
P
D
K
Q
S
T
E
Q
A
I
Q
L
Site 25
T214
Q
L
L
E
K
M
K
T
S
A
S
P
F
F
L
Site 26
Y234
K
P
H
I
P
F
R
Y
P
K
E
F
Q
K
L
Site 27
Y242
P
K
E
F
Q
K
L
Y
P
L
E
N
I
T
L
Site 28
Y264
D
G
L
P
P
V
A
Y
N
P
W
M
D
I
R
Site 29
S282
D
V
Q
A
L
N
I
S
V
P
Y
G
P
I
P
Site 30
S299
F
Q
R
K
I
R
Q
S
Y
F
A
S
V
S
Y
Site 31
Y300
Q
R
K
I
R
Q
S
Y
F
A
S
V
S
Y
L
Site 32
S303
I
R
Q
S
Y
F
A
S
V
S
Y
L
D
T
Q
Site 33
Y348
E
H
G
E
W
A
K
Y
S
N
F
D
V
A
T
Site 34
S369
Y
V
P
G
R
T
A
S
L
P
E
A
G
E
K
Site 35
Y380
A
G
E
K
L
F
P
Y
L
D
P
F
D
S
A
Site 36
S386
P
Y
L
D
P
F
D
S
A
S
Q
L
M
E
P
Site 37
S388
L
D
P
F
D
S
A
S
Q
L
M
E
P
G
R
Site 38
S426
P
P
R
C
P
V
P
S
F
H
V
E
L
C
R
Site 39
Y452
R
D
L
E
E
D
P
Y
L
P
G
N
P
R
E
Site 40
Y463
N
P
R
E
L
I
A
Y
S
Q
Y
P
R
P
S
Site 41
S464
P
R
E
L
I
A
Y
S
Q
Y
P
R
P
S
D
Site 42
Y466
E
L
I
A
Y
S
Q
Y
P
R
P
S
D
I
P
Site 43
S470
Y
S
Q
Y
P
R
P
S
D
I
P
Q
W
N
S
Site 44
S477
S
D
I
P
Q
W
N
S
D
K
P
S
L
K
D
Site 45
S481
Q
W
N
S
D
K
P
S
L
K
D
I
K
I
M
Site 46
Y490
K
D
I
K
I
M
G
Y
S
I
R
T
I
D
Y
Site 47
Y497
Y
S
I
R
T
I
D
Y
R
Y
T
V
W
V
G
Site 48
Y499
I
R
T
I
D
Y
R
Y
T
V
W
V
G
F
N
Site 49
S515
D
E
F
L
A
N
F
S
D
I
H
A
G
E
L
Site 50
Y523
D
I
H
A
G
E
L
Y
F
V
D
S
D
P
L
Site 51
S527
G
E
L
Y
F
V
D
S
D
P
L
Q
D
H
N
Site 52
Y536
P
L
Q
D
H
N
M
Y
N
D
S
Q
G
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation