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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALAS2
Full Name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial
Alias:
5-aminolevulinic acid synthase 2;Delta-ALA synthase 2;Delta-aminolevulinate synthase 2
Type:
Mass (Da):
64633
Number AA:
587
UniProt ID:
P22557
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T43
G
R
C
P
I
L
A
T
Q
G
P
N
C
S
Q
Site 2
S49
A
T
Q
G
P
N
C
S
Q
I
H
L
K
A
T
Site 3
S62
A
T
K
A
G
G
D
S
P
S
W
A
K
G
H
Site 4
S64
K
A
G
G
D
S
P
S
W
A
K
G
H
C
P
Site 5
S75
G
H
C
P
F
M
L
S
E
L
Q
D
G
K
S
Site 6
S82
S
E
L
Q
D
G
K
S
K
I
V
Q
K
A
A
Site 7
T101
E
D
V
K
A
F
K
T
D
L
P
S
S
L
V
Site 8
S111
P
S
S
L
V
S
V
S
L
R
K
P
F
S
G
Site 9
S117
V
S
L
R
K
P
F
S
G
P
Q
E
Q
E
Q
Site 10
T130
E
Q
I
S
G
K
V
T
H
L
I
Q
N
N
M
Site 11
Y141
Q
N
N
M
P
G
N
Y
V
F
S
Y
D
Q
F
Site 12
Y145
P
G
N
Y
V
F
S
Y
D
Q
F
F
R
D
K
Site 13
T161
M
E
K
K
Q
D
H
T
Y
R
V
F
K
T
V
Site 14
Y162
E
K
K
Q
D
H
T
Y
R
V
F
K
T
V
N
Site 15
S182
Y
P
F
A
Q
H
F
S
E
A
S
V
A
S
K
Site 16
S185
A
Q
H
F
S
E
A
S
V
A
S
K
D
V
S
Site 17
S192
S
V
A
S
K
D
V
S
V
W
C
S
N
D
Y
Site 18
Y199
S
V
W
C
S
N
D
Y
L
G
M
S
R
H
P
Site 19
T226
H
G
A
G
A
G
G
T
R
N
I
S
G
T
S
Site 20
S230
A
G
G
T
R
N
I
S
G
T
S
K
F
H
V
Site 21
T232
G
T
R
N
I
S
G
T
S
K
F
H
V
E
L
Site 22
S233
T
R
N
I
S
G
T
S
K
F
H
V
E
L
E
Site 23
S251
A
E
L
H
Q
K
D
S
A
L
L
F
S
S
C
Site 24
Y279
I
L
P
G
C
E
I
Y
S
D
A
G
N
H
A
Site 25
S287
S
D
A
G
N
H
A
S
M
I
Q
G
I
R
N
Site 26
S317
L
K
K
L
L
E
K
S
N
P
K
I
P
K
I
Site 27
T354
S
H
Q
Y
G
A
L
T
F
V
D
E
V
H
A
Site 28
S495
K
L
C
D
L
L
L
S
K
H
G
I
Y
V
Q
Site 29
Y506
I
Y
V
Q
A
I
N
Y
P
T
V
P
R
G
E
Site 30
S521
E
L
L
R
L
A
P
S
P
H
H
S
P
Q
M
Site 31
S525
L
A
P
S
P
H
H
S
P
Q
M
M
E
D
F
Site 32
Y574
M
S
E
W
E
R
S
Y
F
G
N
M
G
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation