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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFX1
Full Name:
MHC class II regulatory factor RFX1
Alias:
EF-C; Enhancer factor C; MHC class II regulatory factor RFX; Regulatory factor X 1; Regulatory factor X, 1 (influences HLA class II expression); RFX; Trans-acting regulatory factor 1; Transcription factor RFX1
Type:
Mass (Da):
104758
Number AA:
979
UniProt ID:
P22670
International Prot ID:
IPI00305337
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003705
GO:0005515
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0006955
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
L
Q
A
A
P
P
P
S
Q
P
P
Q
A
P
P
Site 2
T45
P
Q
P
P
Q
P
P
T
A
A
A
T
P
Q
P
Site 3
T49
Q
P
P
T
A
A
A
T
P
Q
P
Q
Y
V
T
Site 4
Y54
A
A
T
P
Q
P
Q
Y
V
T
E
L
Q
S
P
Site 5
T56
T
P
Q
P
Q
Y
V
T
E
L
Q
S
P
Q
P
Site 6
S60
Q
Y
V
T
E
L
Q
S
P
Q
P
Q
A
Q
P
Site 7
Y74
P
P
G
G
Q
K
Q
Y
V
T
E
L
P
A
V
Site 8
T76
G
G
Q
K
Q
Y
V
T
E
L
P
A
V
P
A
Site 9
T88
V
P
A
P
S
Q
P
T
G
A
P
T
P
S
P
Site 10
T92
S
Q
P
T
G
A
P
T
P
S
P
A
P
Q
Q
Site 11
S94
P
T
G
A
P
T
P
S
P
A
P
Q
Q
Y
I
Site 12
Y100
P
S
P
A
P
Q
Q
Y
I
V
V
T
V
S
E
Site 13
S113
S
E
G
A
M
R
A
S
E
T
V
S
E
A
S
Site 14
T115
G
A
M
R
A
S
E
T
V
S
E
A
S
P
G
Site 15
S117
M
R
A
S
E
T
V
S
E
A
S
P
G
S
T
Site 16
S120
S
E
T
V
S
E
A
S
P
G
S
T
A
S
Q
Site 17
S123
V
S
E
A
S
P
G
S
T
A
S
Q
T
G
V
Site 18
T124
S
E
A
S
P
G
S
T
A
S
Q
T
G
V
P
Site 19
S126
A
S
P
G
S
T
A
S
Q
T
G
V
P
T
Q
Site 20
T128
P
G
S
T
A
S
Q
T
G
V
P
T
Q
V
V
Site 21
S150
Q
R
L
L
V
Q
T
S
V
Q
A
K
P
G
H
Site 22
S159
Q
A
K
P
G
H
V
S
P
L
Q
L
T
N
I
Site 23
T175
V
P
Q
Q
A
L
P
T
Q
R
L
V
V
Q
S
Site 24
S182
T
Q
R
L
V
V
Q
S
A
A
P
G
S
K
G
Site 25
S187
V
Q
S
A
A
P
G
S
K
G
G
Q
V
S
L
Site 26
S193
G
S
K
G
G
Q
V
S
L
T
V
H
G
T
Q
Site 27
T195
K
G
G
Q
V
S
L
T
V
H
G
T
Q
Q
V
Site 28
T199
V
S
L
T
V
H
G
T
Q
Q
V
H
S
P
P
Site 29
S204
H
G
T
Q
Q
V
H
S
P
P
E
Q
S
P
V
Site 30
S209
V
H
S
P
P
E
Q
S
P
V
Q
A
N
S
S
Site 31
S215
Q
S
P
V
Q
A
N
S
S
S
S
K
T
A
G
Site 32
S216
S
P
V
Q
A
N
S
S
S
S
K
T
A
G
A
Site 33
T220
A
N
S
S
S
S
K
T
A
G
A
P
T
G
T
Site 34
T227
T
A
G
A
P
T
G
T
V
P
Q
Q
L
Q
V
Site 35
S240
Q
V
H
G
V
Q
Q
S
V
P
V
T
Q
E
R
Site 36
T244
V
Q
Q
S
V
P
V
T
Q
E
R
S
V
V
Q
Site 37
T253
E
R
S
V
V
Q
A
T
P
Q
A
P
K
P
G
Site 38
S293
P
V
P
H
V
Y
S
S
Q
V
Q
Y
V
E
G
Site 39
Y297
V
Y
S
S
Q
V
Q
Y
V
E
G
G
D
A
S
Site 40
S304
Y
V
E
G
G
D
A
S
Y
T
A
S
A
I
R
Site 41
Y305
V
E
G
G
D
A
S
Y
T
A
S
A
I
R
S
Site 42
T306
E
G
G
D
A
S
Y
T
A
S
A
I
R
S
S
Site 43
S308
G
D
A
S
Y
T
A
S
A
I
R
S
S
T
Y
Site 44
S312
Y
T
A
S
A
I
R
S
S
T
Y
S
Y
P
E
Site 45
S313
T
A
S
A
I
R
S
S
T
Y
S
Y
P
E
T
Site 46
T314
A
S
A
I
R
S
S
T
Y
S
Y
P
E
T
P
Site 47
Y315
S
A
I
R
S
S
T
Y
S
Y
P
E
T
P
L
Site 48
S316
A
I
R
S
S
T
Y
S
Y
P
E
T
P
L
Y
Site 49
Y317
I
R
S
S
T
Y
S
Y
P
E
T
P
L
Y
T
Site 50
T320
S
T
Y
S
Y
P
E
T
P
L
Y
T
Q
T
A
Site 51
Y323
S
Y
P
E
T
P
L
Y
T
Q
T
A
S
T
S
Site 52
T324
Y
P
E
T
P
L
Y
T
Q
T
A
S
T
S
Y
Site 53
T326
E
T
P
L
Y
T
Q
T
A
S
T
S
Y
Y
E
Site 54
S328
P
L
Y
T
Q
T
A
S
T
S
Y
Y
E
A
A
Site 55
Y332
Q
T
A
S
T
S
Y
Y
E
A
A
G
T
A
T
Site 56
T337
S
Y
Y
E
A
A
G
T
A
T
Q
V
S
T
P
Site 57
S342
A
G
T
A
T
Q
V
S
T
P
A
T
S
Q
A
Site 58
T343
G
T
A
T
Q
V
S
T
P
A
T
S
Q
A
V
Site 59
T346
T
Q
V
S
T
P
A
T
S
Q
A
V
A
S
S
Site 60
S347
Q
V
S
T
P
A
T
S
Q
A
V
A
S
S
G
Site 61
S368
S
G
S
Q
V
V
A
S
S
A
S
T
G
A
G
Site 62
S377
A
S
T
G
A
G
A
S
N
S
S
G
G
G
G
Site 63
S379
T
G
A
G
A
S
N
S
S
G
G
G
G
S
G
Site 64
S380
G
A
G
A
S
N
S
S
G
G
G
G
S
G
G
Site 65
S385
N
S
S
G
G
G
G
S
G
G
G
G
G
G
G
Site 66
S400
G
G
G
G
G
G
G
S
G
S
T
G
G
G
G
Site 67
S402
G
G
G
G
G
S
G
S
T
G
G
G
G
S
G
Site 68
T412
G
G
G
S
G
A
G
T
Y
V
I
Q
G
G
Y
Site 69
S423
Q
G
G
Y
M
L
G
S
A
S
Q
S
Y
S
H
Site 70
S425
G
Y
M
L
G
S
A
S
Q
S
Y
S
H
T
T
Site 71
S427
M
L
G
S
A
S
Q
S
Y
S
H
T
T
R
A
Site 72
S429
G
S
A
S
Q
S
Y
S
H
T
T
R
A
S
P
Site 73
T431
A
S
Q
S
Y
S
H
T
T
R
A
S
P
A
T
Site 74
S435
Y
S
H
T
T
R
A
S
P
A
T
V
Q
W
L
Site 75
T438
T
T
R
A
S
P
A
T
V
Q
W
L
L
D
N
Site 76
Y446
V
Q
W
L
L
D
N
Y
E
T
A
E
G
V
S
Site 77
S453
Y
E
T
A
E
G
V
S
L
P
R
S
T
L
Y
Site 78
S457
E
G
V
S
L
P
R
S
T
L
Y
C
H
Y
L
Site 79
Y463
R
S
T
L
Y
C
H
Y
L
L
H
C
Q
E
Q
Site 80
T493
S
V
F
M
G
L
R
T
R
R
L
G
T
R
G
Site 81
T498
L
R
T
R
R
L
G
T
R
G
N
S
K
Y
H
Site 82
S502
R
L
G
T
R
G
N
S
K
Y
H
Y
Y
G
L
Site 83
Y504
G
T
R
G
N
S
K
Y
H
Y
Y
G
L
R
I
Site 84
Y506
R
G
N
S
K
Y
H
Y
Y
G
L
R
I
K
A
Site 85
Y507
G
N
S
K
Y
H
Y
Y
G
L
R
I
K
A
S
Site 86
S514
Y
G
L
R
I
K
A
S
S
P
L
L
R
L
M
Site 87
S535
A
M
R
G
Q
P
F
S
Q
K
Q
R
L
K
P
Site 88
T550
I
Q
K
M
E
G
M
T
N
G
V
A
V
G
Q
Site 89
S560
V
A
V
G
Q
Q
P
S
T
G
L
S
D
I
S
Site 90
S564
Q
Q
P
S
T
G
L
S
D
I
S
A
Q
V
Q
Site 91
S567
S
T
G
L
S
D
I
S
A
Q
V
Q
Q
Y
Q
Site 92
S582
Q
F
L
D
A
S
R
S
L
P
D
F
T
E
L
Site 93
T587
S
R
S
L
P
D
F
T
E
L
D
L
Q
G
K
Site 94
Y641
L
W
K
T
F
W
R
Y
N
L
S
Q
P
S
E
Site 95
S644
T
F
W
R
Y
N
L
S
Q
P
S
E
A
P
P
Site 96
S647
R
Y
N
L
S
Q
P
S
E
A
P
P
L
A
V
Site 97
S717
A
I
R
N
F
A
K
S
L
E
S
W
L
T
H
Site 98
T723
K
S
L
E
S
W
L
T
H
A
M
V
N
I
P
Site 99
T747
A
A
G
A
F
A
Q
T
L
R
R
Y
T
S
L
Site 100
Y751
F
A
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Site 101
T752
A
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Q
Site 102
S753
Q
T
L
R
R
Y
T
S
L
N
H
L
A
Q
A
Site 103
T768
A
R
A
V
L
Q
N
T
A
Q
I
N
Q
M
L
Site 104
S776
A
Q
I
N
Q
M
L
S
D
L
N
R
V
D
F
Site 105
Y836
V
S
Q
V
L
K
P
Y
Q
G
S
A
G
F
P
Site 106
Y882
F
H
L
I
R
L
L
Y
D
E
Y
M
Y
Y
L
Site 107
Y885
I
R
L
L
Y
D
E
Y
M
Y
Y
L
I
E
H
Site 108
Y887
L
L
Y
D
E
Y
M
Y
Y
L
I
E
H
R
V
Site 109
Y888
L
Y
D
E
Y
M
Y
Y
L
I
E
H
R
V
A
Site 110
S915
E
F
A
N
L
A
T
S
L
N
P
L
D
P
D
Site 111
S933
E
E
E
E
E
E
E
S
E
D
E
L
P
Q
D
Site 112
S942
D
E
L
P
Q
D
I
S
L
A
A
G
G
E
S
Site 113
S949
S
L
A
A
G
G
E
S
P
A
L
G
P
E
T
Site 114
T956
S
P
A
L
G
P
E
T
L
E
P
P
A
K
L
Site 115
T966
P
P
A
K
L
A
R
T
D
A
R
G
L
F
V
Site 116
S978
L
F
V
Q
A
L
P
S
S
_
_
_
_
_
_
Site 117
S979
F
V
Q
A
L
P
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation