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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TGM1
Full Name:
Protein-glutamine gamma-glutamyltransferase K
Alias:
Epidermal TGase; ICR2; K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase; KTG; LI; LI1; TG(K); TGASE; TGase K; TGK; Transglutaminase 1; Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase); Transglutaminase K
Type:
Enzyme, transglutaminase
Mass (Da):
89787
Number AA:
817
UniProt ID:
P22735
International Prot ID:
IPI00305622
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0001533
Uniprot
OncoNet
Molecular Function:
GO:0008415
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0043163
GO:0031424
GO:0018149
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
G
N
P
L
Q
P
P
T
T
P
S
P
E
P
E
Site 2
T22
N
P
L
Q
P
P
T
T
P
S
P
E
P
E
P
Site 3
S24
L
Q
P
P
T
T
P
S
P
E
P
E
P
E
P
Site 4
S35
E
P
E
P
D
G
R
S
R
R
G
G
G
R
S
Site 5
S42
S
R
R
G
G
G
R
S
F
W
A
R
C
C
G
Site 6
S66
D
D
W
G
P
E
P
S
D
S
R
G
R
G
S
Site 7
S68
W
G
P
E
P
S
D
S
R
G
R
G
S
S
S
Site 8
S73
S
D
S
R
G
R
G
S
S
S
G
T
R
R
P
Site 9
S74
D
S
R
G
R
G
S
S
S
G
T
R
R
P
G
Site 10
S75
S
R
G
R
G
S
S
S
G
T
R
R
P
G
S
Site 11
T77
G
R
G
S
S
S
G
T
R
R
P
G
S
R
G
Site 12
S82
S
G
T
R
R
P
G
S
R
G
S
D
S
R
R
Site 13
S85
R
R
P
G
S
R
G
S
D
S
R
R
P
V
S
Site 14
S87
P
G
S
R
G
S
D
S
R
R
P
V
S
R
G
Site 15
S92
S
D
S
R
R
P
V
S
R
G
S
G
V
N
A
Site 16
S95
R
R
P
V
S
R
G
S
G
V
N
A
A
G
D
Site 17
T104
V
N
A
A
G
D
G
T
I
R
E
G
M
L
V
Site 18
S119
V
N
G
V
D
L
L
S
S
R
S
D
Q
N
R
Site 19
S120
N
G
V
D
L
L
S
S
R
S
D
Q
N
R
R
Site 20
S122
V
D
L
L
S
S
R
S
D
Q
N
R
R
E
H
Site 21
T131
Q
N
R
R
E
H
H
T
D
E
Y
E
Y
D
E
Site 22
Y134
R
E
H
H
T
D
E
Y
E
Y
D
E
L
I
V
Site 23
Y136
H
H
T
D
E
Y
E
Y
D
E
L
I
V
R
R
Site 24
S154
F
H
M
L
L
L
L
S
R
T
Y
E
S
S
D
Site 25
T156
M
L
L
L
L
S
R
T
Y
E
S
S
D
R
I
Site 26
Y157
L
L
L
L
S
R
T
Y
E
S
S
D
R
I
T
Site 27
S160
L
S
R
T
Y
E
S
S
D
R
I
T
L
E
L
Site 28
T164
Y
E
S
S
D
R
I
T
L
E
L
L
I
G
N
Site 29
T211
N
L
N
L
R
V
H
T
S
P
N
A
I
I
G
Site 30
S212
L
N
L
R
V
H
T
S
P
N
A
I
I
G
K
Site 31
T223
I
I
G
K
F
Q
F
T
V
R
T
Q
S
D
A
Site 32
S228
Q
F
T
V
R
T
Q
S
D
A
G
E
F
Q
L
Site 33
Y267
H
E
D
W
R
Q
E
Y
V
L
N
E
S
G
R
Site 34
Y276
L
N
E
S
G
R
I
Y
Y
G
T
E
A
Q
I
Site 35
Y277
N
E
S
G
R
I
Y
Y
G
T
E
A
Q
I
G
Site 36
T279
S
G
R
I
Y
Y
G
T
E
A
Q
I
G
E
R
Site 37
Y290
I
G
E
R
T
W
N
Y
G
Q
F
D
H
G
V
Site 38
Y312
L
D
R
R
G
M
P
Y
G
G
R
G
D
P
V
Site 39
S343
G
V
L
I
G
N
W
S
G
D
Y
S
R
G
T
Site 40
Y346
I
G
N
W
S
G
D
Y
S
R
G
T
N
P
S
Site 41
S347
G
N
W
S
G
D
Y
S
R
G
T
N
P
S
A
Site 42
T350
S
G
D
Y
S
R
G
T
N
P
S
A
W
V
G
Site 43
S353
Y
S
R
G
T
N
P
S
A
W
V
G
S
V
E
Site 44
Y365
S
V
E
I
L
L
S
Y
L
R
T
G
Y
S
V
Site 45
Y370
L
S
Y
L
R
T
G
Y
S
V
P
Y
G
Q
C
Site 46
T399
G
L
A
T
R
T
V
T
N
F
N
S
A
H
D
Site 47
S403
R
T
V
T
N
F
N
S
A
H
D
T
D
T
S
Site 48
T407
N
F
N
S
A
H
D
T
D
T
S
L
T
M
D
Site 49
T409
N
S
A
H
D
T
D
T
S
L
T
M
D
I
Y
Site 50
S410
S
A
H
D
T
D
T
S
L
T
M
D
I
Y
F
Site 51
Y416
T
S
L
T
M
D
I
Y
F
D
E
N
M
K
P
Site 52
S450
M
K
R
P
D
L
P
S
G
F
D
G
W
Q
V
Site 53
T461
G
W
Q
V
V
D
A
T
P
Q
E
T
S
S
G
Site 54
Y486
S
I
K
N
G
L
V
Y
M
K
Y
D
T
P
F
Site 55
Y504
E
V
N
S
D
K
V
Y
W
Q
R
Q
D
D
G
Site 56
Y517
D
G
S
F
K
I
V
Y
V
E
E
K
A
I
G
Site 57
S534
I
V
T
K
A
I
S
S
N
M
R
E
D
I
T
Site 58
T541
S
N
M
R
E
D
I
T
Y
L
Y
K
H
P
E
Site 59
Y542
N
M
R
E
D
I
T
Y
L
Y
K
H
P
E
G
Site 60
Y544
R
E
D
I
T
Y
L
Y
K
H
P
E
G
S
D
Site 61
T559
A
E
R
K
A
V
E
T
A
A
A
H
G
S
K
Site 62
S565
E
T
A
A
A
H
G
S
K
P
N
V
Y
A
N
Site 63
Y570
H
G
S
K
P
N
V
Y
A
N
R
G
S
A
E
Site 64
S575
N
V
Y
A
N
R
G
S
A
E
D
V
A
M
Q
Site 65
S604
S
V
M
L
I
N
H
S
S
S
R
R
T
V
K
Site 66
S605
V
M
L
I
N
H
S
S
S
R
R
T
V
K
L
Site 67
S606
M
L
I
N
H
S
S
S
R
R
T
V
K
L
H
Site 68
T609
N
H
S
S
S
R
R
T
V
K
L
H
L
Y
L
Site 69
T647
P
G
A
S
D
R
V
T
M
P
V
A
Y
K
E
Site 70
Y652
R
V
T
M
P
V
A
Y
K
E
Y
R
P
H
L
Site 71
T685
Q
V
L
A
K
Q
H
T
F
R
L
R
T
P
D
Site 72
T690
Q
H
T
F
R
L
R
T
P
D
L
S
L
T
L
Site 73
T749
G
D
I
G
G
N
E
T
V
T
L
R
Q
S
F
Site 74
T751
I
G
G
N
E
T
V
T
L
R
Q
S
F
V
P
Site 75
S755
E
T
V
T
L
R
Q
S
F
V
P
V
R
P
G
Site 76
S769
G
P
R
Q
L
I
A
S
L
D
S
P
Q
L
S
Site 77
S772
Q
L
I
A
S
L
D
S
P
Q
L
S
Q
V
H
Site 78
S776
S
L
D
S
P
Q
L
S
Q
V
H
G
V
I
Q
Site 79
S797
P
G
D
G
G
F
F
S
D
A
G
G
D
S
H
Site 80
S803
F
S
D
A
G
G
D
S
H
L
G
E
T
I
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation