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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CA4
Full Name:
Carbonic anhydrase 4
Alias:
Carbonic anhydrase IV
Type:
Mass (Da):
35014
Number AA:
312
UniProt ID:
P22748
International Prot ID:
IPI00027466
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000267
GO:0005624
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004089
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0003008
GO:0006730
GO:0007600
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
L
S
A
A
R
P
S
A
S
A
E
S
H
W
Site 2
S18
S
A
A
R
P
S
A
S
A
E
S
H
W
C
Y
Site 3
Y25
S
A
E
S
H
W
C
Y
E
V
Q
A
E
S
S
Site 4
Y34
V
Q
A
E
S
S
N
Y
P
C
L
V
P
V
K
Site 5
S52
N
C
Q
K
D
R
Q
S
P
I
N
I
V
T
T
Site 6
S73
K
L
G
R
F
F
F
S
G
Y
D
K
K
Q
T
Site 7
Y75
G
R
F
F
F
S
G
Y
D
K
K
Q
T
W
T
Site 8
T80
S
G
Y
D
K
K
Q
T
W
T
V
Q
N
N
G
Site 9
T82
Y
D
K
K
Q
T
W
T
V
Q
N
N
G
H
S
Site 10
S89
T
V
Q
N
N
G
H
S
V
M
M
L
L
E
N
Site 11
Y109
G
G
G
L
P
A
P
Y
Q
A
K
Q
L
H
L
Site 12
S119
K
Q
L
H
L
H
W
S
D
L
P
Y
K
G
S
Site 13
Y123
L
H
W
S
D
L
P
Y
K
G
S
E
H
S
L
Site 14
S126
S
D
L
P
Y
K
G
S
E
H
S
L
D
G
E
Site 15
S129
P
Y
K
G
S
E
H
S
L
D
G
E
H
F
A
Site 16
S188
Q
P
L
V
E
A
L
S
N
I
P
K
P
E
M
Site 17
S196
N
I
P
K
P
E
M
S
T
T
M
A
E
S
S
Site 18
T198
P
K
P
E
M
S
T
T
M
A
E
S
S
L
L
Site 19
S203
S
T
T
M
A
E
S
S
L
L
D
L
L
P
K
Site 20
Y217
K
E
E
K
L
R
H
Y
F
R
Y
L
G
S
L
Site 21
Y220
K
L
R
H
Y
F
R
Y
L
G
S
L
T
T
P
Site 22
T226
R
Y
L
G
S
L
T
T
P
T
C
D
E
K
V
Site 23
S253
R
E
Q
I
L
A
F
S
Q
K
L
Y
Y
D
K
Site 24
Y257
L
A
F
S
Q
K
L
Y
Y
D
K
E
Q
T
V
Site 25
T263
L
Y
Y
D
K
E
Q
T
V
S
M
K
D
N
V
Site 26
T280
L
Q
Q
L
G
Q
R
T
V
I
K
S
G
A
P
Site 27
S284
G
Q
R
T
V
I
K
S
G
A
P
G
R
P
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation