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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AADAC
Full Name:
Arylacetamide deacetylase
Alias:
AAAD; DAC; EC 3.1.1.-
Type:
Enzyme - Deacetylase
Mass (Da):
45748
Number AA:
399
UniProt ID:
P22760
International Prot ID:
IPI00383879
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005789
GO:0016021
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0004091
GO:0019213
GO:0016298
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
G
R
K
S
L
Y
L
L
I
V
G
I
L
Site 2
Y17
I
V
G
I
L
I
A
Y
Y
I
Y
T
P
L
P
Site 3
Y18
V
G
I
L
I
A
Y
Y
I
Y
T
P
L
P
D
Site 4
S67
D
S
F
K
V
V
G
S
F
D
E
V
P
P
T
Site 5
T74
S
F
D
E
V
P
P
T
S
D
E
N
V
T
V
Site 6
S75
F
D
E
V
P
P
T
S
D
E
N
V
T
V
T
Site 7
T80
P
T
S
D
E
N
V
T
V
T
E
T
K
F
N
Site 8
Y94
N
N
I
L
V
R
V
Y
V
P
K
R
K
S
E
Site 9
S100
V
Y
V
P
K
R
K
S
E
A
L
R
R
G
L
Site 10
Y125
G
S
A
A
L
S
G
Y
D
L
L
S
R
W
T
Site 11
S129
L
S
G
Y
D
L
L
S
R
W
T
A
D
R
L
Site 12
T132
Y
D
L
L
S
R
W
T
A
D
R
L
D
A
V
Site 13
Y151
N
Y
R
L
A
P
K
Y
H
F
P
I
Q
F
E
Site 14
Y176
R
K
K
V
L
A
K
Y
G
V
N
P
E
R
I
Site 15
S186
N
P
E
R
I
G
I
S
G
D
S
A
G
G
N
Site 16
S231
P
L
D
V
D
L
P
S
Y
Q
E
N
S
N
F
Site 17
Y232
L
D
V
D
L
P
S
Y
Q
E
N
S
N
F
L
Site 18
Y253
M
V
R
F
W
S
E
Y
F
T
T
D
R
S
L
Site 19
T255
R
F
W
S
E
Y
F
T
T
D
R
S
L
E
K
Site 20
T256
F
W
S
E
Y
F
T
T
D
R
S
L
E
K
A
Site 21
S259
E
Y
F
T
T
D
R
S
L
E
K
A
M
L
S
Site 22
S266
S
L
E
K
A
M
L
S
R
Q
H
V
P
V
E
Site 23
Y297
R
F
I
K
G
H
V
Y
N
N
P
N
Y
G
S
Site 24
Y302
H
V
Y
N
N
P
N
Y
G
S
S
E
L
A
K
Site 25
Y311
S
S
E
L
A
K
K
Y
P
G
F
L
D
V
R
Site 26
T339
L
P
L
T
Y
V
I
T
C
Q
Y
D
L
L
R
Site 27
Y342
T
Y
V
I
T
C
Q
Y
D
L
L
R
D
D
G
Site 28
Y352
L
R
D
D
G
L
M
Y
V
T
R
L
R
N
T
Site 29
T359
Y
V
T
R
L
R
N
T
G
V
Q
V
T
H
N
Site 30
S384
S
F
L
G
L
K
I
S
H
R
L
I
N
Q
Y
Site 31
Y391
S
H
R
L
I
N
Q
Y
I
E
W
L
K
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation