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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MMP8
Full Name:
Neutrophil collagenase
Alias:
Matrix metalloproteinase-8;PMNL collagenase
Type:
Mass (Da):
53412
Number AA:
467
UniProt ID:
P22894
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
I
S
K
A
F
P
V
S
S
K
E
K
N
T
K
Site 2
S25
S
K
A
F
P
V
S
S
K
E
K
N
T
K
T
Site 3
T30
V
S
S
K
E
K
N
T
K
T
V
Q
D
Y
L
Site 4
T32
S
K
E
K
N
T
K
T
V
Q
D
Y
L
E
K
Site 5
Y36
N
T
K
T
V
Q
D
Y
L
E
K
F
Y
Q
L
Site 6
Y41
Q
D
Y
L
E
K
F
Y
Q
L
P
S
N
Q
Y
Site 7
S45
E
K
F
Y
Q
L
P
S
N
Q
Y
Q
S
T
R
Site 8
S50
L
P
S
N
Q
Y
Q
S
T
R
K
N
G
T
N
Site 9
S96
P
R
C
G
V
P
D
S
G
G
F
M
L
T
P
Site 10
T102
D
S
G
G
F
M
L
T
P
G
N
P
K
W
E
Site 11
Y115
W
E
R
T
N
L
T
Y
R
I
R
N
Y
T
P
Site 12
Y120
L
T
Y
R
I
R
N
Y
T
P
Q
L
S
E
A
Site 13
T121
T
Y
R
I
R
N
Y
T
P
Q
L
S
E
A
E
Site 14
S125
R
N
Y
T
P
Q
L
S
E
A
E
V
E
R
A
Site 15
S152
P
L
I
F
T
R
I
S
Q
G
E
A
D
I
N
Site 16
Y163
A
D
I
N
I
A
F
Y
Q
R
D
H
G
D
N
Site 17
S171
Q
R
D
H
G
D
N
S
P
F
D
G
P
N
G
Site 18
S222
A
A
H
E
F
G
H
S
L
G
L
A
H
S
S
Site 19
S228
H
S
L
G
L
A
H
S
S
D
P
G
A
L
M
Site 20
Y236
S
D
P
G
A
L
M
Y
P
N
Y
A
F
R
E
Site 21
Y239
G
A
L
M
Y
P
N
Y
A
F
R
E
T
S
N
Site 22
T244
P
N
Y
A
F
R
E
T
S
N
Y
S
L
P
Q
Site 23
S245
N
Y
A
F
R
E
T
S
N
Y
S
L
P
Q
D
Site 24
Y247
A
F
R
E
T
S
N
Y
S
L
P
Q
D
D
I
Site 25
S248
F
R
E
T
S
N
Y
S
L
P
Q
D
D
I
D
Site 26
S265
Q
A
I
Y
G
L
S
S
N
P
I
Q
P
T
G
Site 27
T271
S
S
N
P
I
Q
P
T
G
P
S
T
P
K
P
Site 28
S274
P
I
Q
P
T
G
P
S
T
P
K
P
C
D
P
Site 29
T275
I
Q
P
T
G
P
S
T
P
K
P
C
D
P
S
Site 30
Y302
I
L
F
F
K
D
R
Y
F
W
R
R
H
P
Q
Site 31
Y349
F
L
F
K
G
N
Q
Y
W
A
L
S
G
Y
D
Site 32
Y355
Q
Y
W
A
L
S
G
Y
D
I
L
Q
G
Y
P
Site 33
Y361
G
Y
D
I
L
Q
G
Y
P
K
D
I
S
N
Y
Site 34
S366
Q
G
Y
P
K
D
I
S
N
Y
G
F
P
S
S
Site 35
Y368
Y
P
K
D
I
S
N
Y
G
F
P
S
S
V
Q
Site 36
S373
S
N
Y
G
F
P
S
S
V
Q
A
I
D
A
A
Site 37
Y388
V
F
Y
R
S
K
T
Y
F
F
V
N
D
Q
F
Site 38
Y409
R
Q
F
M
E
P
G
Y
P
K
S
I
S
G
A
Site 39
S412
M
E
P
G
Y
P
K
S
I
S
G
A
F
P
G
Site 40
S414
P
G
Y
P
K
S
I
S
G
A
F
P
G
I
E
Site 41
S422
G
A
F
P
G
I
E
S
K
V
D
A
V
F
Q
Site 42
T453
D
L
I
A
Q
R
V
T
R
V
A
R
G
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation