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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTGS1
Full Name:
Prostaglandin G/H synthase 1
Alias:
Cyclooxygenase-1;Prostaglandin H2 synthase 1;Prostaglandin-endoperoxide synthase 1
Type:
Mass (Da):
68656
Number AA:
599
UniProt ID:
P23219
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Prostaglandin G/H synthase 1 pan-specific antibody AB-NN381-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN381-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y54
V
R
F
G
L
D
R
Y
Q
C
D
C
T
R
T
Site 2
Y63
C
D
C
T
R
T
G
Y
S
G
P
N
C
T
I
Site 3
S80
L
W
T
W
L
R
N
S
L
R
P
S
P
S
F
Site 4
S84
L
R
N
S
L
R
P
S
P
S
F
T
H
F
L
Site 5
S86
N
S
L
R
P
S
P
S
F
T
H
F
L
L
T
Site 6
T88
L
R
P
S
P
S
F
T
H
F
L
L
T
H
G
Site 7
S125
V
R
S
N
L
I
P
S
P
P
T
Y
N
S
A
Site 8
Y129
L
I
P
S
P
P
T
Y
N
S
A
H
D
Y
I
Site 9
S131
P
S
P
P
T
Y
N
S
A
H
D
Y
I
S
W
Site 10
Y135
T
Y
N
S
A
H
D
Y
I
S
W
E
S
F
S
Site 11
Y146
E
S
F
S
N
V
S
Y
Y
T
R
I
L
P
S
Site 12
Y147
S
F
S
N
V
S
Y
Y
T
R
I
L
P
S
V
Site 13
S153
Y
Y
T
R
I
L
P
S
V
P
K
D
C
P
T
Site 14
T160
S
V
P
K
D
C
P
T
P
M
G
T
K
G
K
Site 15
T220
G
K
M
G
P
G
F
T
K
A
L
G
H
G
V
Site 16
Y233
G
V
D
L
G
H
I
Y
G
D
N
L
E
R
Q
Site 17
Y241
G
D
N
L
E
R
Q
Y
Q
L
R
L
F
K
D
Site 18
Y253
F
K
D
G
K
L
K
Y
Q
V
L
D
G
E
M
Site 19
Y261
Q
V
L
D
G
E
M
Y
P
P
S
V
E
E
A
Site 20
S264
D
G
E
M
Y
P
P
S
V
E
E
A
P
V
L
Site 21
Y274
E
A
P
V
L
M
H
Y
P
R
G
I
P
P
Q
Site 22
S282
P
R
G
I
P
P
Q
S
Q
M
A
V
G
Q
E
Site 23
Y354
Y
V
Q
Q
L
S
G
Y
F
L
Q
L
K
F
D
Site 24
Y372
L
F
G
V
Q
F
Q
Y
R
N
R
I
A
M
E
Site 25
S393
W
H
P
L
M
P
D
S
F
K
V
G
S
Q
E
Site 26
S398
P
D
S
F
K
V
G
S
Q
E
Y
S
Y
E
Q
Site 27
S402
K
V
G
S
Q
E
Y
S
Y
E
Q
F
L
F
N
Site 28
Y403
V
G
S
Q
E
Y
S
Y
E
Q
F
L
F
N
T
Site 29
S454
A
V
D
V
I
R
E
S
R
E
M
R
L
Q
P
Site 30
Y465
R
L
Q
P
F
N
E
Y
R
K
R
F
G
M
K
Site 31
T475
R
F
G
M
K
P
Y
T
S
F
Q
E
L
V
G
Site 32
S476
F
G
M
K
P
Y
T
S
F
Q
E
L
V
G
E
Site 33
S540
L
L
G
N
P
I
C
S
P
E
Y
W
K
P
S
Site 34
Y543
N
P
I
C
S
P
E
Y
W
K
P
S
T
F
G
Site 35
S547
S
P
E
Y
W
K
P
S
T
F
G
G
E
V
G
Site 36
T548
P
E
Y
W
K
P
S
T
F
G
G
E
V
G
F
Site 37
Y576
L
N
T
K
T
C
P
Y
V
S
F
R
V
P
D
Site 38
S578
T
K
T
C
P
Y
V
S
F
R
V
P
D
A
S
Site 39
S585
S
F
R
V
P
D
A
S
Q
D
D
G
P
A
V
Site 40
S596
G
P
A
V
E
R
P
S
T
E
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation