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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CA6
Full Name:
Carbonic anhydrase 6
Alias:
Carbonate dehydratase VI;Carbonic anhydrase VI;Salivary carbonic anhydrase;Secreted carbonic anhydrase
Type:
Mass (Da):
35367
Number AA:
308
UniProt ID:
P23280
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
G
G
Q
A
Q
H
V
S
D
W
T
Y
S
E
G
Site 2
T24
A
Q
H
V
S
D
W
T
Y
S
E
G
A
L
D
Site 3
Y25
Q
H
V
S
D
W
T
Y
S
E
G
A
L
D
E
Site 4
S48
A
C
G
G
Q
R
Q
S
P
I
N
L
Q
R
T
Site 5
Y59
L
Q
R
T
K
V
R
Y
N
P
S
L
K
G
L
Site 6
S62
T
K
V
R
Y
N
P
S
L
K
G
L
N
M
T
Site 7
Y71
K
G
L
N
M
T
G
Y
E
T
Q
A
G
E
F
Site 8
T86
P
M
V
N
N
G
H
T
V
Q
I
S
L
P
S
Site 9
S90
N
G
H
T
V
Q
I
S
L
P
S
T
M
R
M
Site 10
S118
H
F
H
W
G
G
A
S
S
E
I
S
G
S
E
Site 11
S119
F
H
W
G
G
A
S
S
E
I
S
G
S
E
H
Site 12
S122
G
G
A
S
S
E
I
S
G
S
E
H
T
V
D
Site 13
S124
A
S
S
E
I
S
G
S
E
H
T
V
D
G
I
Site 14
T127
E
I
S
G
S
E
H
T
V
D
G
I
R
H
V
Site 15
Y142
I
E
I
H
I
V
H
Y
N
S
K
Y
K
S
Y
Site 16
Y146
I
V
H
Y
N
S
K
Y
K
S
Y
D
I
A
Q
Site 17
Y171
A
F
V
E
V
K
N
Y
P
E
N
T
Y
Y
S
Site 18
Y176
K
N
Y
P
E
N
T
Y
Y
S
N
F
I
S
H
Site 19
Y177
N
Y
P
E
N
T
Y
Y
S
N
F
I
S
H
L
Site 20
Y189
S
H
L
A
N
I
K
Y
P
G
Q
R
T
T
L
Site 21
T195
K
Y
P
G
Q
R
T
T
L
T
G
L
D
V
Q
Site 22
T197
P
G
Q
R
T
T
L
T
G
L
D
V
Q
D
M
Site 23
Y212
L
P
R
N
L
Q
H
Y
Y
T
Y
H
G
S
L
Site 24
Y213
P
R
N
L
Q
H
Y
Y
T
Y
H
G
S
L
T
Site 25
T214
R
N
L
Q
H
Y
Y
T
Y
H
G
S
L
T
T
Site 26
T220
Y
T
Y
H
G
S
L
T
T
P
P
C
T
E
N
Site 27
T221
T
Y
H
G
S
L
T
T
P
P
C
T
E
N
V
Site 28
T242
D
F
V
K
L
S
R
T
Q
V
W
K
L
E
N
Site 29
S250
Q
V
W
K
L
E
N
S
L
L
D
H
R
N
K
Site 30
T258
L
L
D
H
R
N
K
T
I
H
N
D
Y
R
R
Site 31
Y263
N
K
T
I
H
N
D
Y
R
R
T
Q
P
L
N
Site 32
Y283
S
N
F
P
N
Q
E
Y
T
L
G
S
E
F
Q
Site 33
Y292
L
G
S
E
F
Q
F
Y
L
H
K
I
E
E
I
Site 34
Y302
K
I
E
E
I
L
D
Y
L
R
R
A
L
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation