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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HRC
Full Name:
Sarcoplasmic reticulum histidine-rich calcium-binding protein
Alias:
HCP; Histidine rich calcium binding protein; MGC133236; SRCH
Type:
Calcium-binding protein
Mass (Da):
80244
Number AA:
699
UniProt ID:
P23327
International Prot ID:
IPI00219226
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0033018
Uniprot
OncoNet
Molecular Function:
GO:0005509
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
G
F
R
N
R
N
N
S
T
G
V
A
G
L
S
Site 2
S50
S
T
G
V
A
G
L
S
E
E
A
S
A
E
L
Site 3
S54
A
G
L
S
E
E
A
S
A
E
L
R
H
H
L
Site 4
S63
E
L
R
H
H
L
H
S
P
R
D
H
P
D
E
Site 5
S75
P
D
E
N
K
D
V
S
T
E
N
G
H
H
F
Site 6
S96
E
K
E
D
E
D
V
S
K
E
Y
G
H
L
L
Site 7
Y99
D
E
D
V
S
K
E
Y
G
H
L
L
P
G
H
Site 8
S108
H
L
L
P
G
H
R
S
Q
D
H
K
V
G
D
Site 9
S119
K
V
G
D
E
G
V
S
G
E
E
V
F
A
E
Site 10
S139
R
G
H
R
G
H
G
S
E
D
T
E
D
S
A
Site 11
T142
R
G
H
G
S
E
D
T
E
D
S
A
E
H
R
Site 12
S145
G
S
E
D
T
E
D
S
A
E
H
R
H
H
L
Site 13
S154
E
H
R
H
H
L
P
S
H
R
S
H
S
H
Q
Site 14
S157
H
H
L
P
S
H
R
S
H
S
H
Q
D
E
D
Site 15
S159
L
P
S
H
R
S
H
S
H
Q
D
E
D
E
D
Site 16
S171
D
E
D
E
V
V
S
S
E
H
H
H
H
I
L
Site 17
S206
E
E
E
E
E
E
A
S
T
E
Y
G
H
Q
A
Site 18
T207
E
E
E
E
E
A
S
T
E
Y
G
H
Q
A
H
Site 19
Y209
E
E
E
A
S
T
E
Y
G
H
Q
A
H
R
H
Site 20
S221
H
R
H
R
G
H
G
S
E
E
D
E
D
V
S
Site 21
S228
S
E
E
D
E
D
V
S
D
G
H
H
H
H
G
Site 22
S263
D
D
D
D
D
D
V
S
I
E
Y
R
H
Q
A
Site 23
S285
I
E
E
D
E
D
V
S
D
G
H
H
H
R
D
Site 24
S294
G
H
H
H
R
D
P
S
H
R
H
R
S
H
E
Site 25
S299
D
P
S
H
R
H
R
S
H
E
E
D
D
N
D
Site 26
S311
D
N
D
D
D
D
V
S
T
E
Y
G
H
Q
A
Site 27
T312
N
D
D
D
D
V
S
T
E
Y
G
H
Q
A
H
Site 28
S358
E
E
E
D
E
D
V
S
T
E
R
W
H
Q
G
Site 29
T359
E
E
D
E
D
V
S
T
E
R
W
H
Q
G
P
Site 30
T384
E
E
E
E
E
E
I
T
V
Q
F
G
H
Y
V
Site 31
Y390
I
T
V
Q
F
G
H
Y
V
A
S
H
Q
P
R
Site 32
S401
H
Q
P
R
G
H
K
S
D
E
E
D
F
Q
D
Site 33
Y410
E
E
D
F
Q
D
E
Y
K
T
E
V
P
H
H
Site 34
S431
R
E
E
D
E
E
V
S
A
E
L
G
H
Q
A
Site 35
S440
E
L
G
H
Q
A
P
S
H
R
Q
S
H
Q
D
Site 36
S444
Q
A
P
S
H
R
Q
S
H
Q
D
E
E
T
G
Site 37
S457
T
G
H
G
Q
R
G
S
I
K
E
M
S
H
H
Site 38
S462
R
G
S
I
K
E
M
S
H
H
P
P
G
H
T
Site 39
T469
S
H
H
P
P
G
H
T
V
V
K
D
R
S
H
Site 40
S482
S
H
L
R
K
D
D
S
E
E
E
K
E
K
E
Site 41
S494
E
K
E
E
D
P
G
S
H
E
E
D
D
E
S
Site 42
S501
S
H
E
E
D
D
E
S
S
E
Q
G
E
K
G
Site 43
S502
H
E
E
D
D
E
S
S
E
Q
G
E
K
G
T
Site 44
S529
E
E
E
G
H
G
L
S
L
N
Q
E
E
E
E
Site 45
S563
A
E
V
G
A
P
L
S
P
D
H
S
E
E
E
Site 46
S567
A
P
L
S
P
D
H
S
E
E
E
E
E
E
E
Site 47
T585
E
E
D
E
P
R
F
T
I
I
P
N
P
L
D
Site 48
S602
E
E
A
G
G
A
S
S
E
E
E
S
G
E
D
Site 49
S606
G
A
S
S
E
E
E
S
G
E
D
T
G
P
Q
Site 50
T610
E
E
E
S
G
E
D
T
G
P
Q
D
A
Q
E
Site 51
Y618
G
P
Q
D
A
Q
E
Y
G
N
Y
Q
P
G
S
Site 52
Y621
D
A
Q
E
Y
G
N
Y
Q
P
G
S
L
C
G
Site 53
S677
E
T
V
C
A
P
G
S
Y
V
D
Y
F
S
S
Site 54
Y678
T
V
C
A
P
G
S
Y
V
D
Y
F
S
S
S
Site 55
Y681
A
P
G
S
Y
V
D
Y
F
S
S
S
L
Y
Q
Site 56
S683
G
S
Y
V
D
Y
F
S
S
S
L
Y
Q
A
L
Site 57
S685
Y
V
D
Y
F
S
S
S
L
Y
Q
A
L
A
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation