KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
ME2
Full Name:
NAD-dependent malic enzyme, mitochondrial
Alias:
Malic enzyme 2
Type:
Mass (Da):
65444
Number AA:
584
UniProt ID:
P23368
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S77
R
N
L
K
K
M
T
S
P
L
E
K
Y
I
Y
Site 2
Y84
S
P
L
E
K
Y
I
Y
I
M
G
I
Q
E
R
Site 3
Y97
E
R
N
E
K
L
F
Y
R
I
L
Q
D
D
I
Site 4
S106
I
L
Q
D
D
I
E
S
L
M
P
I
V
Y
T
Site 5
Y123
V
G
L
A
C
S
Q
Y
G
H
I
F
R
R
P
Site 6
S136
R
P
K
G
L
F
I
S
I
S
D
R
G
H
V
Site 7
S138
K
G
L
F
I
S
I
S
D
R
G
H
V
R
S
Site 8
S145
S
D
R
G
H
V
R
S
I
V
D
N
W
P
E
Site 9
Y175
G
L
G
D
L
G
V
Y
G
M
G
I
P
V
G
Site 10
Y218
A
L
L
K
D
P
F
Y
M
G
L
Y
Q
K
R
Site 11
Y222
D
P
F
Y
M
G
L
Y
Q
K
R
D
R
T
Q
Site 12
T228
L
Y
Q
K
R
D
R
T
Q
Q
Y
D
D
L
I
Site 13
T243
D
E
F
M
K
A
I
T
D
R
Y
G
R
N
T
Site 14
Y246
M
K
A
I
T
D
R
Y
G
R
N
T
L
I
Q
Site 15
T250
T
D
R
Y
G
R
N
T
L
I
Q
F
E
D
F
Site 16
Y269
A
F
R
F
L
R
K
Y
R
E
K
Y
C
T
F
Site 17
Y273
L
R
K
Y
R
E
K
Y
C
T
F
N
D
D
I
Site 18
T283
F
N
D
D
I
Q
G
T
A
A
V
A
L
A
G
Site 19
S299
L
A
A
Q
K
V
I
S
K
P
I
S
E
H
K
Site 20
S333
S
M
V
E
N
G
L
S
E
Q
E
A
Q
K
K
Site 21
Y347
K
I
W
M
F
D
K
Y
G
L
L
V
K
G
R
Site 22
S360
G
R
K
A
K
I
D
S
Y
Q
E
P
F
T
H
Site 23
Y361
R
K
A
K
I
D
S
Y
Q
E
P
F
T
H
S
Site 24
T366
D
S
Y
Q
E
P
F
T
H
S
A
P
E
S
I
Site 25
S368
Y
Q
E
P
F
T
H
S
A
P
E
S
I
P
D
Site 26
S372
F
T
H
S
A
P
E
S
I
P
D
T
F
E
D
Site 27
T376
A
P
E
S
I
P
D
T
F
E
D
A
V
N
I
Site 28
S420
R
P
V
I
F
A
L
S
N
P
T
A
Q
A
E
Site 29
T435
C
T
A
E
E
A
Y
T
L
T
E
G
R
C
L
Site 30
T437
A
E
E
A
Y
T
L
T
E
G
R
C
L
F
A
Site 31
T455
P
F
G
P
V
K
L
T
D
G
R
V
F
T
P
Site 32
T461
L
T
D
G
R
V
F
T
P
G
Q
G
N
N
V
Site 33
S489
N
T
R
H
I
S
D
S
V
F
L
E
A
A
K
Site 34
Y513
E
L
A
Q
G
R
L
Y
P
P
L
A
N
I
Q
Site 35
Y535
I
K
V
T
E
Y
L
Y
A
N
K
M
A
F
R
Site 36
Y543
A
N
K
M
A
F
R
Y
P
E
P
E
D
K
A
Site 37
Y552
E
P
E
D
K
A
K
Y
V
K
E
R
T
W
R
Site 38
T557
A
K
Y
V
K
E
R
T
W
R
S
E
Y
D
S
Site 39
S560
V
K
E
R
T
W
R
S
E
Y
D
S
L
L
P
Site 40
Y562
E
R
T
W
R
S
E
Y
D
S
L
L
P
D
V
Site 41
S564
T
W
R
S
E
Y
D
S
L
L
P
D
V
Y
E
Site 42
Y570
D
S
L
L
P
D
V
Y
E
W
P
E
S
A
S
Site 43
S575
D
V
Y
E
W
P
E
S
A
S
S
P
P
V
I
Site 44
S578
E
W
P
E
S
A
S
S
P
P
V
I
T
E
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation