KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RRM1
Full Name:
Ribonucleoside-diphosphate reductase large subunit
Alias:
EC 1.17.4.1; R1; Ribonucleoside-diphosphate reductase M1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1; RIR1; RR1
Type:
Other Amino Acids Metabolism - glutathione; Oxidoreductase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; EC 1.17.4.1
Mass (Da):
90070
Number AA:
792
UniProt ID:
P23921
International Prot ID:
IPI00013871
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005971
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004748
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
R
V
M
F
D
K
I
T
S
R
I
Q
K
L
C
Site 2
T66
L
A
A
E
T
A
A
T
L
T
T
K
H
P
D
Site 3
S95
K
E
T
K
K
V
F
S
D
V
M
E
D
L
Y
Site 4
Y102
S
D
V
M
E
D
L
Y
N
Y
I
N
P
H
N
Site 5
Y104
V
M
E
D
L
Y
N
Y
I
N
P
H
N
G
K
Site 6
S113
N
P
H
N
G
K
H
S
P
M
V
A
K
S
T
Site 7
S119
H
S
P
M
V
A
K
S
T
L
D
I
V
L
A
Site 8
T120
S
P
M
V
A
K
S
T
L
D
I
V
L
A
N
Site 9
S133
A
N
K
D
R
L
N
S
A
I
I
Y
D
R
D
Site 10
Y137
R
L
N
S
A
I
I
Y
D
R
D
F
S
Y
N
Site 11
Y143
I
Y
D
R
D
F
S
Y
N
Y
F
G
F
K
T
Site 12
Y145
D
R
D
F
S
Y
N
Y
F
G
F
K
T
L
E
Site 13
T150
Y
N
Y
F
G
F
K
T
L
E
R
S
Y
L
L
Site 14
Y155
F
K
T
L
E
R
S
Y
L
L
K
I
N
G
K
Site 15
T199
L
L
S
E
R
W
F
T
H
A
S
P
T
L
F
Site 16
S202
E
R
W
F
T
H
A
S
P
T
L
F
N
A
G
Site 17
T210
P
T
L
F
N
A
G
T
N
R
P
Q
L
S
S
Site 18
S216
G
T
N
R
P
Q
L
S
S
C
F
L
L
S
M
Site 19
S217
T
N
R
P
Q
L
S
S
C
F
L
L
S
M
K
Site 20
S227
L
L
S
M
K
D
D
S
I
E
G
I
Y
D
T
Site 21
Y232
D
D
S
I
E
G
I
Y
D
T
L
K
Q
C
A
Site 22
S260
S
C
I
R
A
T
G
S
Y
I
A
G
T
N
G
Site 23
Y261
C
I
R
A
T
G
S
Y
I
A
G
T
N
G
N
Site 24
T265
T
G
S
Y
I
A
G
T
N
G
N
S
N
G
L
Site 25
T282
M
L
R
V
Y
N
N
T
A
R
Y
V
D
Q
G
Site 26
Y285
V
Y
N
N
T
A
R
Y
V
D
Q
G
G
N
K
Site 27
Y300
R
P
G
A
F
A
I
Y
L
E
P
W
H
L
D
Site 28
Y371
G
E
E
F
E
K
L
Y
A
S
Y
E
K
Q
G
Site 29
S373
E
F
E
K
L
Y
A
S
Y
E
K
Q
G
R
V
Site 30
S396
L
W
Y
A
I
I
E
S
Q
T
E
T
G
T
P
Site 31
T400
I
I
E
S
Q
T
E
T
G
T
P
Y
M
L
Y
Site 32
T402
E
S
Q
T
E
T
G
T
P
Y
M
L
Y
K
D
Site 33
Y404
Q
T
E
T
G
T
P
Y
M
L
Y
K
D
S
C
Site 34
Y407
T
G
T
P
Y
M
L
Y
K
D
S
C
N
R
K
Site 35
S415
K
D
S
C
N
R
K
S
N
Q
Q
N
L
G
T
Site 36
T422
S
N
Q
Q
N
L
G
T
I
K
C
S
N
L
C
Site 37
Y435
L
C
T
E
I
V
E
Y
T
S
K
D
E
V
A
Site 38
Y454
A
S
L
A
L
N
M
Y
V
T
S
E
H
T
Y
Site 39
Y461
Y
V
T
S
E
H
T
Y
D
F
K
K
L
A
E
Site 40
Y485
N
K
I
I
D
I
N
Y
Y
P
V
P
E
A
C
Site 41
Y486
K
I
I
D
I
N
Y
Y
P
V
P
E
A
C
L
Site 42
S494
P
V
P
E
A
C
L
S
N
K
R
H
R
P
I
Site 43
S521
L
M
R
Y
P
F
E
S
A
E
A
Q
L
L
N
Site 44
Y536
K
Q
I
F
E
T
I
Y
Y
G
A
L
E
A
S
Site 45
Y553
L
A
K
E
Q
G
P
Y
E
T
Y
E
G
S
P
Site 46
T555
K
E
Q
G
P
Y
E
T
Y
E
G
S
P
V
S
Site 47
Y556
E
Q
G
P
Y
E
T
Y
E
G
S
P
V
S
K
Site 48
S559
P
Y
E
T
Y
E
G
S
P
V
S
K
G
I
L
Site 49
S562
T
Y
E
G
S
P
V
S
K
G
I
L
Q
Y
D
Site 50
Y591
L
K
E
K
I
A
K
Y
G
I
R
N
S
L
L
Site 51
S616
Q
I
L
G
N
N
E
S
I
E
P
Y
T
S
N
Site 52
Y620
N
N
E
S
I
E
P
Y
T
S
N
I
Y
T
R
Site 53
S622
E
S
I
E
P
Y
T
S
N
I
Y
T
R
R
V
Site 54
Y625
E
P
Y
T
S
N
I
Y
T
R
R
V
L
S
G
Site 55
T626
P
Y
T
S
N
I
Y
T
R
R
V
L
S
G
E
Site 56
S631
I
Y
T
R
R
V
L
S
G
E
F
Q
I
V
N
Site 57
T646
P
H
L
L
K
D
L
T
E
R
G
L
W
H
E
Site 58
S668
A
C
N
G
S
I
Q
S
I
P
E
I
P
D
D
Site 59
Y680
P
D
D
L
K
Q
L
Y
K
T
V
W
E
I
S
Site 60
T682
D
L
K
Q
L
Y
K
T
V
W
E
I
S
Q
K
Site 61
S705
R
G
A
F
I
D
Q
S
Q
S
L
N
I
H
I
Site 62
S707
A
F
I
D
Q
S
Q
S
L
N
I
H
I
A
E
Site 63
Y717
I
H
I
A
E
P
N
Y
G
K
L
T
S
M
H
Site 64
Y726
K
L
T
S
M
H
F
Y
G
W
K
Q
G
L
K
Site 65
T734
G
W
K
Q
G
L
K
T
G
M
Y
Y
L
R
T
Site 66
Y737
Q
G
L
K
T
G
M
Y
Y
L
R
T
R
P
A
Site 67
Y738
G
L
K
T
G
M
Y
Y
L
R
T
R
P
A
A
Site 68
T751
A
A
N
P
I
Q
F
T
L
N
K
E
K
L
K
Site 69
T774
E
E
E
K
E
R
N
T
A
A
M
V
C
S
L
Site 70
S780
N
T
A
A
M
V
C
S
L
E
N
R
D
E
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation