PhosphoNET

           
Protein Info 
   
Short Name:  LAMA2
Full Name:  Laminin subunit alpha-2
Alias:  Congenital muscular dystrophy; Laminin alpha-2; Laminin M; Laminin, alpha 2; LAMM; Merosin; Merosin heavy chain
Type:  Extracellular matrix
Mass (Da):  342771
Number AA:  3110
UniProt ID:  P24043
International Prot ID:  IPI00844276
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005606     Uniprot OncoNet
Molecular Function:  GO:0005102  GO:0005198   PhosphoSite+ KinaseNET
Biological Process:  GO:0007155  GO:0007517  GO:0030155 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S31RPQQQRQSQAHQQRG
Site 2Y66GEKGPEMYCKLVEHV
Site 3T100PNQRHPITNAIDGKN
Site 4Y123KNGIEYHYVTITLDL
Site 5S146VIVKAANSPRPGNWI
Site 6S157GNWILERSLDDVEYK
Site 7Y163RSLDDVEYKPWQYHA
Site 8T174QYHAVTDTECLTLYN
Site 9T178VTDTECLTLYNIYPR
Site 10Y180DTECLTLYNIYPRTG
Site 11Y183CLTLYNIYPRTGPPS
Site 12T186LYNIYPRTGPPSYAK
Site 13S190YPRTGPPSYAKDDEV
Site 14Y191PRTGPPSYAKDDEVI
Site 15T200KDDEVICTSFYSKIH
Site 16S217ENGEIHISLINGRPS
Site 17S224SLINGRPSADDPSPE
Site 18S229RPSADDPSPELLEFT
Site 19S237PELLEFTSARYIRLR
Site 20Y240LEFTSARYIRLRFQR
Site 21T250LRFQRIRTLNADLMM
Site 22Y274DPIVTRRYYYSVKDI
Site 23Y275PIVTRRYYYSVKDIS
Site 24Y276IVTRRYYYSVKDISV
Site 25S277VTRRYYYSVKDISVG
Site 26T302ACPLDPATNKSRCEC
Site 27T334QKPWRAGTFLTKTEC
Site 28Y354HGKAEECYYDENVAR
Site 29Y355GKAEECYYDENVARR
Site 30S365NVARRNLSLNIRGKY
Site 31S404FFRPKGVSPNYPRPC
Site 32Y407PKGVSPNYPRPCQPC
Site 33S441RRGLAPGSCHCKTGF
Site 34T446PGSCHCKTGFGGVSC
Site 35S452KTGFGGVSCDRCARG
Site 36Y460CDRCARGYTGYPDCK
Site 37T461DRCARGYTGYPDCKA
Site 38Y463CARGYTGYPDCKACN
Site 39S502GDCSRCKSGFFNLQE
Site 40Y531SNRCQSSYWTYGKIQ
Site 41Y534CQSSYWTYGKIQDMS
Site 42Y544IQDMSGWYLTDLPGR
Site 43T546DMSGWYLTDLPGRIR
Site 44S563PQQDDLDSPQQISIS
Site 45S570SPQQISISNAEARQA
Site 46S581ARQALPHSYYWSAPA
Site 47Y583QALPHSYYWSAPAPY
Site 48S585LPHSYYWSAPAPYLG
Site 49T605VGGQLTFTISYDLEE
Site 50S607GQLTFTISYDLEEEE
Site 51T617LEEEEEDTERVLQLM
Site 52S633ILEGNDLSISTAQDE
Site 53S635EGNDLSISTAQDEVY
Site 54Y642STAQDEVYLHPSEEH
Site 55T650LHPSEEHTNVLLLKE
Site 56T661LLKEESFTIHGTHFP
Site 57T665ESFTIHGTHFPVRRK
Site 58T676VRRKEFMTVLANLKR
Site 59S707LSSVNLESAVSYPTD
Site 60S710VNLESAVSYPTDGSI
Site 61Y711NLESAVSYPTDGSIA
Site 62Y730VCQCPPGYTGSSCES
Site 63T748RHRRVNGTIFGGICE
Site 64T770AESCDDVTGECLNCK
Site 65Y784KDHTGGPYCDKCLPG
Site 66Y793DKCLPGFYGEPTKGT
Site 67T797PGFYGEPTKGTSEDC
Site 68S819NIPSNNFSPTCHLDR
Site 69Y839CDGCPVGYTGPRCER
Site 70Y851CERCAEGYFGQPSVP
Site 71S856EGYFGQPSVPGGSCQ
Site 72S874CNDNLDFSIPGSCDS
Site 73S878LDFSIPGSCDSLSGS
Site 74S925CRCNAGGSFSEVCHS
Site 75S927CNAGGSFSEVCHSQT
Site 76T955CDKCKAGTFGLQSAR
Site 77S976CNSFGSKSFDCEESG
Site 78Y1003CDRCAHGYFNFQEGG
Site 79T1036RCICPPNTIGEKCSK
Site 80T1116FLPGTDATTCDSETK
Site 81T1117LPGTDATTCDSETKK
Site 82S1120TDATTCDSETKKCSC
Site 83T1122ATTCDSETKKCSCSD
Site 84S1126DSETKKCSCSDQTGQ
Site 85S1176FGTTTQCSEAKGLIR
Site 86Y1234DLHLEPFYWKLPEQF
Site 87Y1249EGKKLMAYGGKLKYA
Site 88Y1255AYGGKLKYAIYFEAR
Site 89Y1258GKLKYAIYFEAREET
Site 90T1265YFEAREETGFSTYNP
Site 91T1269REETGFSTYNPQVII
Site 92Y1270EETGFSTYNPQVIIR
Site 93T1307TRHEIEMTEKEWKYY
Site 94Y1313MTEKEWKYYGDDPRV
Site 95Y1314TEKEWKYYGDDPRVH
Site 96T1323DDPRVHRTVTREDFL
Site 97T1325PRVHRTVTREDFLDI
Site 98S1352YGNFMRQSRISEISM
Site 99S1355FMRQSRISEISMEVA
Site 100S1358QSRISEISMEVAEQG
Site 101T1368VAEQGRGTTMTPPAD
Site 102T1369AEQGRGTTMTPPADL
Site 103T1371QGRGTTMTPPADLIE
Site 104S1403PGFYRLRSQPGGRTP
Site 105T1409RSQPGGRTPGPTLGT
Site 106T1413GGRTPGPTLGTCVPC
Site 107S1427CQCNGHSSLCDPETS
Site 108S1475QCACPLISSSNNFSP
Site 109S1476CACPLISSSNNFSPS
Site 110S1477ACPLISSSNNFSPSC
Site 111S1481ISSSNNFSPSCVAEG
Site 112S1483SSNNFSPSCVAEGLD
Site 113Y1492VAEGLDDYRCTACPR
Site 114Y1501CTACPRGYEGQYCER
Site 115Y1505PRGYEGQYCERCAPG
Site 116Y1513CERCAPGYTGSPGNP
Site 117T1514ERCAPGYTGSPGNPG
Site 118S1516CAPGYTGSPGNPGGS
Site 119S1523SPGNPGGSCQECECD
Site 120Y1532QECECDPYGSLPVPC
Site 121S1534CECDPYGSLPVPCDP
Site 122T1547DPVTGFCTCRPGATG
Site 123Y1606TGPLPAPYKMLYGLE
Site 124Y1610PAPYKMLYGLENMTQ
Site 125S1624QELKHLLSPQRAPER
Site 126T1655NELLTRATKVTADGE
Site 127T1658LTRATKVTADGEQTG
Site 128T1673QDAERTNTRAKSLGE
Site 129S1677RTNTRAKSLGEFIKE
Site 130T1735LRRKNLETQKEIAED
Site 131Y1779LREKLADYKNKVDDA
Site 132T1794WDLLREATDKIREAN
Site 133S1823KKKEAVESGKRQIEN
Site 134T1831GKRQIENTLKEGNDI
Site 135Y1855EINSIIDYVEDIQTK
Site 136T1861DYVEDIQTKLPPMSE
Site 137S1867QTKLPPMSEELNDKI
Site 138S1878NDKIDDLSQEIKDRK
Site 139S1891RKLAEKVSQAESHAA
Site 140S1895EKVSQAESHAAQLND
Site 141T1922KNISFNATAAFKAYS
Site 142Y1934AYSNIKDYIDEAEKV
Site 143S1974AKGCLQKSFRILNEA
Site 144T2015RNGDLLRTLNDTLGK
Site 145S2024NDTLGKLSAIPNDTA
Site 146T2047KARQANDTAKDVLAQ
Site 147S2075NYNKLADSVAKTNAV
Site 148T2079LADSVAKTNAVVKDP
Site 149T2098IIADADATVKNLEQE
Site 150S2128DNLKKNISEIKELIN
Site 151S2143QARKQANSIKVSVSS
Site 152S2147QANSIKVSVSSGGDC
Site 153S2149NSIKVSVSSGGDCIR
Site 154T2157SGGDCIRTYKPEIKK
Site 155Y2158GGDCIRTYKPEIKKG
Site 156S2205EMRKGKVSFLWDVGS
Site 157Y2219SGVGRVEYPDLTIDD
Site 158T2223RVEYPDLTIDDSYWY
Site 159Y2228DLTIDDSYWYRIVAS
Site 160T2237YRIVASRTGRNGTIS
Site 161T2242SRTGRNGTISVRALD
Site 162S2244TGRNGTISVRALDGP
Site 163S2254ALDGPKASIVPSTHH
Site 164S2258PKASIVPSTHHSTSP
Site 165T2259KASIVPSTHHSTSPP
Site 166S2262IVPSTHHSTSPPGYT
Site 167S2264PSTHHSTSPPGYTIL
Site 168Y2307TGCMGETYFDNKPIG
Site 169T2329EGDCKGCTVSPQVED
Site 170S2331DCKGCTVSPQVEDSE
Site 171S2337VSPQVEDSEGTIQFD
Site 172S2352GEGYALVSRPIRWYP
Site 173Y2358VSRPIRWYPNISTVM
Site 174T2370TVMFKFRTFSSSALL
Site 175S2374KFRTFSSSALLMYLA
Site 176Y2379SSSALLMYLATRDLR
Site 177T2382ALLMYLATRDLRDFM
Site 178S2390RDLRDFMSVELTDGH
Site 179T2394DFMSVELTDGHIKVS
Site 180S2401TDGHIKVSYDLGSGM
Site 181Y2402DGHIKVSYDLGSGMA
Site 182S2410DLGSGMASVVSNQNH
Site 183S2413SGMASVVSNQNHNDG
Site 184S2424HNDGKWKSFTLSRIQ
Site 185T2426DGKWKSFTLSRIQKQ
Site 186S2428KWKSFTLSRIQKQAN
Site 187T2443ISIVDIDTNQEENIA
Site 188T2451NQEENIATSSSGNNF
Site 189S2454ENIATSSSGNNFGLD
Site 190S2480LPTLRNLSMKARPEV
Site 191T2504KDIEISRTPYNILSS
Site 192Y2506IEISRTPYNILSSPD
Site 193S2510RTPYNILSSPDYVGV
Site 194S2511TPYNILSSPDYVGVT
Site 195Y2514NILSSPDYVGVTKGC
Site 196T2518SPDYVGVTKGCSLEN
Site 197Y2527GCSLENVYTVSFPKP
Site 198T2528CSLENVYTVSFPKPG
Site 199S2553VGTEINLSFSTKNES
Site 200S2555TEINLSFSTKNESGI
Site 201S2567SGIILLGSGGTPAPP
Site 202T2570ILLGSGGTPAPPRRK
Site 203T2581PRRKRRQTGQAYYAI
Site 204Y2585RRQTGQAYYAILLNR
Site 205S2600GRLEVHLSTGARTMR
Site 206T2605HLSTGARTMRKIVIR
Site 207S2625FHDGREHSVHVERTR
Site 208T2636ERTRGIFTVQVDENR
Site 209Y2645QVDENRRYMQNLTVE
Site 210T2650RRYMQNLTVEQPIEV
Site 211S2672APPEFQPSPLRNIPP
Site 212S2701MDFARPVSFKNADIG
Site 213T2736IQPEPVPTPAFPTPT
Site 214T2743TPAFPTPTPVLTHGP
Site 215T2747PTPTPVLTHGPCAAE
Site 216S2769GSKQFGLSRNSHIAI
Site 217S2772QFGLSRNSHIAIAFD
Site 218T2781IAIAFDDTKVKNRLT
Site 219T2788TKVKNRLTIELEVRT
Site 220T2815INHADFATVQLRNGL
Site 221Y2824QLRNGLPYFSYDLGS
Site 222S2826RNGLPYFSYDLGSGD
Site 223Y2827NGLPYFSYDLGSGDT
Site 224T2834YDLGSGDTHTMIPTK
Site 225T2836LGSGDTHTMIPTKIN
Site 226Y2862SKQEGILYVDGASNR
Site 227S2867ILYVDGASNRTISPK
Site 228S2872GASNRTISPKKADIL
Site 229Y2886LDVVGMLYVGGLPIN
Site 230Y2894VGGLPINYTTRRIGP
Site 231T2895GGLPINYTTRRIGPV
Site 232S2905RIGPVTYSIDGCVRN
Site 233S2927ADLEQPTSSFHVGTC
Site 234S2928DLEQPTSSFHVGTCF
Site 235T2942FANAQRGTYFDGTGF
Site 236Y2943ANAQRGTYFDGTGFA
Site 237T2947RGTYFDGTGFAKAVG
Site 238T2974EFRTTTTTGVLLGIS
Site 239T3009DNGAGRFTAVYDAGV
Site 240T3040IKHRIELTVDGNQVE
Site 241S3050GNQVEAQSPNPASTS
Site 242S3055AQSPNPASTSADTND
Site 243T3060PASTSADTNDPVFVG
Site 244S3090PFRGCIRSLKLTKGT
Site 245T3094CIRSLKLTKGTGKPL
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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