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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHM
Full Name:
Rab proteins geranylgeranyltransferase component A 1
Alias:
Choroideraemia; Choroideraemia protein; Choroideremia; DXS540; GGTA; HSD-32; Rab escort 1; Rab escort protein 1; RAE1; REP1; REP-1; REP-1, Rab escort 1; TCD; TCD protein
Type:
Transferase
Mass (Da):
73476
Number AA:
653
UniProt ID:
P24386
International Prot ID:
IPI00028099
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005968
GO:0005730
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0004663
GO:0004661
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
GO:0018348
GO:0043087
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
R
R
V
L
H
V
D
S
R
S
Y
Y
G
G
N
Site 2
Y42
L
H
V
D
S
R
S
Y
Y
G
G
N
W
A
S
Site 3
Y43
H
V
D
S
R
S
Y
Y
G
G
N
W
A
S
F
Site 4
S57
F
S
F
S
G
L
L
S
W
L
K
E
Y
Q
E
Site 5
Y62
L
L
S
W
L
K
E
Y
Q
E
N
S
D
I
V
Site 6
S66
L
K
E
Y
Q
E
N
S
D
I
V
S
D
S
P
Site 7
S70
Q
E
N
S
D
I
V
S
D
S
P
V
W
Q
D
Site 8
S72
N
S
D
I
V
S
D
S
P
V
W
Q
D
Q
I
Site 9
S89
N
E
E
A
I
A
L
S
R
K
D
K
T
I
Q
Site 10
T94
A
L
S
R
K
D
K
T
I
Q
H
V
E
V
F
Site 11
Y103
Q
H
V
E
V
F
C
Y
A
S
Q
D
L
H
E
Site 12
S136
N
S
T
E
A
A
D
S
A
F
L
P
T
E
D
Site 13
T141
A
D
S
A
F
L
P
T
E
D
E
S
L
S
T
Site 14
S145
F
L
P
T
E
D
E
S
L
S
T
M
S
C
E
Site 15
S147
P
T
E
D
E
S
L
S
T
M
S
C
E
M
L
Site 16
T148
T
E
D
E
S
L
S
T
M
S
C
E
M
L
T
Site 17
T155
T
M
S
C
E
M
L
T
E
Q
T
P
S
S
D
Site 18
T158
C
E
M
L
T
E
Q
T
P
S
S
D
P
E
N
Site 19
S160
M
L
T
E
Q
T
P
S
S
D
P
E
N
A
L
Site 20
S161
L
T
E
Q
T
P
S
S
D
P
E
N
A
L
E
Site 21
T186
E
N
H
C
D
D
K
T
C
V
P
S
T
S
A
Site 22
S192
K
T
C
V
P
S
T
S
A
E
D
M
S
E
N
Site 23
S197
S
T
S
A
E
D
M
S
E
N
V
P
I
A
E
Site 24
T207
V
P
I
A
E
D
T
T
E
Q
P
K
K
N
R
Site 25
T216
Q
P
K
K
N
R
I
T
Y
S
Q
I
I
K
E
Site 26
Y217
P
K
K
N
R
I
T
Y
S
Q
I
I
K
E
G
Site 27
S218
K
K
N
R
I
T
Y
S
Q
I
I
K
E
G
R
Site 28
S233
R
F
N
I
D
L
V
S
K
L
L
Y
S
R
G
Site 29
Y237
D
L
V
S
K
L
L
Y
S
R
G
L
L
I
D
Site 30
S238
L
V
S
K
L
L
Y
S
R
G
L
L
I
D
L
Site 31
Y254
I
K
S
N
V
S
R
Y
A
E
F
K
N
I
T
Site 32
S277
R
V
E
Q
V
P
C
S
R
A
D
V
F
N
S
Site 33
T288
V
F
N
S
K
Q
L
T
M
V
E
K
R
M
L
Site 34
Y305
F
L
T
F
C
M
E
Y
E
K
Y
P
D
E
Y
Site 35
Y308
F
C
M
E
Y
E
K
Y
P
D
E
Y
K
G
Y
Site 36
Y312
Y
E
K
Y
P
D
E
Y
K
G
Y
E
E
I
T
Site 37
Y315
Y
P
D
E
Y
K
G
Y
E
E
I
T
F
Y
E
Site 38
Y321
G
Y
E
E
I
T
F
Y
E
Y
L
K
T
Q
K
Site 39
T326
T
F
Y
E
Y
L
K
T
Q
K
L
T
P
N
L
Site 40
T330
Y
L
K
T
Q
K
L
T
P
N
L
Q
Y
I
V
Site 41
S349
A
M
T
S
E
T
A
S
S
T
I
D
G
L
K
Site 42
S350
M
T
S
E
T
A
S
S
T
I
D
G
L
K
A
Site 43
Y378
T
P
F
L
F
P
L
Y
G
Q
G
E
L
P
Q
Site 44
S429
Q
F
G
Q
R
I
I
S
E
H
F
L
V
E
D
Site 45
Y438
H
F
L
V
E
D
S
Y
F
P
E
N
M
C
S
Site 46
Y449
N
M
C
S
R
V
Q
Y
R
Q
I
S
R
A
V
Site 47
S453
R
V
Q
Y
R
Q
I
S
R
A
V
L
I
T
D
Site 48
S462
A
V
L
I
T
D
R
S
V
L
K
T
D
S
D
Site 49
T466
T
D
R
S
V
L
K
T
D
S
D
Q
Q
I
S
Site 50
S468
R
S
V
L
K
T
D
S
D
Q
Q
I
S
I
L
Site 51
T476
D
Q
Q
I
S
I
L
T
V
P
A
E
E
P
G
Site 52
S494
V
R
V
I
E
L
C
S
S
T
M
T
C
M
K
Site 53
S495
R
V
I
E
L
C
S
S
T
M
T
C
M
K
G
Site 54
S513
V
H
L
T
C
T
S
S
K
T
A
R
E
D
L
Site 55
T515
L
T
C
T
S
S
K
T
A
R
E
D
L
E
S
Site 56
S522
T
A
R
E
D
L
E
S
V
V
Q
K
L
F
V
Site 57
T532
Q
K
L
F
V
P
Y
T
E
M
E
I
E
N
E
Site 58
Y551
P
R
I
L
W
A
L
Y
F
N
M
R
D
S
S
Site 59
S557
L
Y
F
N
M
R
D
S
S
D
I
S
R
S
C
Site 60
S558
Y
F
N
M
R
D
S
S
D
I
S
R
S
C
Y
Site 61
S561
M
R
D
S
S
D
I
S
R
S
C
Y
N
D
L
Site 62
S563
D
S
S
D
I
S
R
S
C
Y
N
D
L
P
S
Site 63
Y565
S
D
I
S
R
S
C
Y
N
D
L
P
S
N
V
Site 64
Y573
N
D
L
P
S
N
V
Y
V
C
S
G
P
D
C
Site 65
S620
D
I
I
L
D
G
D
S
L
Q
P
E
A
S
E
Site 66
S626
D
S
L
Q
P
E
A
S
E
S
S
A
I
P
E
Site 67
T638
I
P
E
A
N
S
E
T
F
K
E
S
T
N
L
Site 68
S651
N
L
G
N
L
E
E
S
S
E
_
_
_
_
_
Site 69
S652
L
G
N
L
E
E
S
S
E
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation