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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CRHBP
Full Name:
Corticotropin-releasing factor-binding protein
Alias:
Corticotropin releasing hormone binding protein; Corticotropin releasing hormone-binding protein; Corticotropin-releasing factor binding protein; CRF-binding protein; CRFBP; CRF-BP; CRH-BP
Type:
Inhibitor protein
Mass (Da):
36144
Number AA:
322
UniProt ID:
P24387
International Prot ID:
IPI00306844
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007565
GO:0007611
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
T
A
L
R
G
E
S
R
Y
L
E
L
R
E
Site 2
Y25
A
L
R
G
E
S
R
Y
L
E
L
R
E
A
A
Site 3
Y34
E
L
R
E
A
A
D
Y
D
P
F
L
L
F
S
Site 4
T71
L
S
L
Q
G
Q
F
T
F
T
A
D
R
P
Q
Site 5
T94
S
E
P
E
E
F
I
T
I
H
Y
D
Q
V
S
Site 6
Y97
E
E
F
I
T
I
H
Y
D
Q
V
S
I
D
C
Site 7
S125
L
K
G
E
K
F
P
S
S
Q
D
H
P
L
P
Site 8
S126
K
G
E
K
F
P
S
S
Q
D
H
P
L
P
S
Site 9
S133
S
Q
D
H
P
L
P
S
A
E
R
Y
I
D
F
Site 10
Y137
P
L
P
S
A
E
R
Y
I
D
F
C
E
S
G
Site 11
S143
R
Y
I
D
F
C
E
S
G
L
S
R
R
S
I
Site 12
S146
D
F
C
E
S
G
L
S
R
R
S
I
R
S
S
Site 13
S149
E
S
G
L
S
R
R
S
I
R
S
S
Q
N
V
Site 14
S152
L
S
R
R
S
I
R
S
S
Q
N
V
A
M
I
Site 15
S153
S
R
R
S
I
R
S
S
Q
N
V
A
M
I
F
Site 16
T173
P
G
N
G
F
T
L
T
I
K
T
D
P
N
L
Site 17
T189
P
C
N
V
I
S
Q
T
P
N
G
K
F
T
L
Site 18
T195
Q
T
P
N
G
K
F
T
L
V
V
P
H
Q
H
Site 19
S206
P
H
Q
H
R
N
C
S
F
S
I
I
Y
P
V
Site 20
S233
N
G
L
Q
L
K
K
S
S
A
G
C
E
G
I
Site 21
S234
G
L
Q
L
K
K
S
S
A
G
C
E
G
I
G
Site 22
S255
G
G
T
G
L
D
P
S
K
M
T
P
L
A
D
Site 23
T258
G
L
D
P
S
K
M
T
P
L
A
D
L
C
Y
Site 24
Y265
T
P
L
A
D
L
C
Y
P
F
H
G
P
A
Q
Site 25
S286
N
T
V
V
R
M
V
S
S
G
K
H
V
N
R
Site 26
T295
G
K
H
V
N
R
V
T
F
E
Y
R
Q
L
E
Site 27
Y298
V
N
R
V
T
F
E
Y
R
Q
L
E
P
Y
E
Site 28
Y304
E
Y
R
Q
L
E
P
Y
E
L
E
N
P
N
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation