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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ETB
Full Name:
Endothelin B receptor
Alias:
EDNRB; endothelin B receptor; endothelin receptor non-selective type; endothelin receptor type B; ET-B; ETBR; ETRB; HSCR; HSCR2
Type:
G protein-coupled 7TM receptor
Mass (Da):
49644
Number AA:
442
UniProt ID:
P24530
International Prot ID:
IPI00029123
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0001600
PhosphoSite+
KinaseNET
Biological Process:
GO:0007200
GO:0048246
GO:0007194
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
G
F
P
P
D
R
A
T
P
L
L
Q
T
A
E
Site 2
T47
L
Q
T
A
E
I
M
T
P
P
T
K
T
L
W
Site 3
T52
I
M
T
P
P
T
K
T
L
W
P
K
G
S
N
Site 4
S58
K
T
L
W
P
K
G
S
N
A
S
L
A
R
S
Site 5
S61
W
P
K
G
S
N
A
S
L
A
R
S
L
A
P
Site 6
S65
S
N
A
S
L
A
R
S
L
A
P
A
E
V
P
Site 7
T77
E
V
P
K
G
D
R
T
A
G
S
P
P
R
T
Site 8
S80
K
G
D
R
T
A
G
S
P
P
R
T
I
S
P
Site 9
T84
T
A
G
S
P
P
R
T
I
S
P
P
P
C
Q
Site 10
S86
G
S
P
P
R
T
I
S
P
P
P
C
Q
G
P
Site 11
T99
G
P
I
E
I
K
E
T
F
K
Y
I
N
T
V
Site 12
Y102
E
I
K
E
T
F
K
Y
I
N
T
V
V
S
C
Site 13
Y127
S
T
L
L
R
I
I
Y
K
N
K
C
M
R
N
Site 14
Y200
C
A
L
S
I
D
R
Y
R
A
V
A
S
W
S
Site 15
S205
D
R
Y
R
A
V
A
S
W
S
R
I
K
G
I
Site 16
Y251
T
M
D
Y
K
G
S
Y
L
R
I
C
L
L
H
Site 17
S305
C
E
M
L
R
K
K
S
G
M
Q
I
A
L
N
Site 18
T348
L
S
R
I
L
K
L
T
L
Y
N
Q
N
D
P
Site 19
Y350
R
I
L
K
L
T
L
Y
N
Q
N
D
P
N
R
Site 20
S407
C
L
C
C
W
C
Q
S
F
E
E
K
Q
S
L
Site 21
S413
Q
S
F
E
E
K
Q
S
L
E
E
K
Q
S
C
Site 22
S419
Q
S
L
E
E
K
Q
S
C
L
K
F
K
A
N
Site 23
Y430
F
K
A
N
D
H
G
Y
D
N
F
R
S
S
N
Site 24
S435
H
G
Y
D
N
F
R
S
S
N
K
Y
S
S
S
Site 25
S436
G
Y
D
N
F
R
S
S
N
K
Y
S
S
S
_
Site 26
Y439
N
F
R
S
S
N
K
Y
S
S
S
_
_
_
_
Site 27
S440
F
R
S
S
N
K
Y
S
S
S
_
_
_
_
_
Site 28
S441
R
S
S
N
K
Y
S
S
S
_
_
_
_
_
_
Site 29
S442
S
S
N
K
Y
S
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation