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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKAP5
Full Name:
A-kinase anchor protein 5
Alias:
A-kinase anchor protein 79 kDa;H21;cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein
Type:
Mass (Da):
47088
Number AA:
427
UniProt ID:
P24588
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
E
N
K
D
E
K
R
S
A
E
G
S
P
G
A
Site 2
S22
E
K
R
S
A
E
G
S
P
G
A
E
R
Q
K
Site 3
S53
A
L
K
P
K
A
G
S
E
A
A
D
V
A
R
Site 4
S69
C
P
Q
E
A
G
A
S
D
Q
P
E
P
T
R
Site 5
S81
P
T
R
G
A
W
A
S
L
K
R
L
V
T
R
Site 6
T87
A
S
L
K
R
L
V
T
R
R
K
R
S
E
S
Site 7
S92
L
V
T
R
R
K
R
S
E
S
S
K
Q
Q
K
Site 8
S94
T
R
R
K
R
S
E
S
S
K
Q
Q
K
P
L
Site 9
S95
R
R
K
R
S
E
S
S
K
Q
Q
K
P
L
E
Site 10
S117
N
A
E
D
A
D
L
S
K
K
K
A
K
S
R
Site 11
S123
L
S
K
K
K
A
K
S
R
L
K
I
P
C
I
Site 12
S139
F
P
R
G
P
K
R
S
N
H
S
K
I
I
E
Site 13
S142
G
P
K
R
S
N
H
S
K
I
I
E
D
S
D
Site 14
S148
H
S
K
I
I
E
D
S
D
C
S
I
K
V
Q
Site 15
T165
A
E
I
L
D
I
Q
T
Q
T
P
L
N
D
Q
Site 16
T167
I
L
D
I
Q
T
Q
T
P
L
N
D
Q
A
T
Site 17
T174
T
P
L
N
D
Q
A
T
K
A
K
S
T
Q
D
Site 18
S178
D
Q
A
T
K
A
K
S
T
Q
D
L
S
E
G
Site 19
S183
A
K
S
T
Q
D
L
S
E
G
I
S
Q
K
D
Site 20
S187
Q
D
L
S
E
G
I
S
Q
K
D
G
D
E
V
Site 21
S197
D
G
D
E
V
C
E
S
N
V
S
N
S
I
T
Site 22
S200
E
V
C
E
S
N
V
S
N
S
I
T
S
G
E
Site 23
T204
S
N
V
S
N
S
I
T
S
G
E
K
V
I
S
Site 24
S211
T
S
G
E
K
V
I
S
V
E
L
G
L
D
N
Site 25
S221
L
G
L
D
N
G
H
S
A
I
Q
T
G
T
L
Site 26
T225
N
G
H
S
A
I
Q
T
G
T
L
I
L
E
E
Site 27
T235
L
I
L
E
E
I
E
T
I
K
E
K
Q
D
V
Site 28
S248
D
V
Q
P
Q
Q
A
S
P
L
E
T
S
E
T
Site 29
T255
S
P
L
E
T
S
E
T
D
H
Q
Q
P
V
L
Site 30
S263
D
H
Q
Q
P
V
L
S
D
V
P
P
L
P
A
Site 31
S283
I
V
E
E
A
S
N
S
T
L
E
S
A
P
N
Site 32
S287
A
S
N
S
T
L
E
S
A
P
N
G
K
D
Y
Site 33
Y294
S
A
P
N
G
K
D
Y
E
S
T
E
I
V
A
Site 34
S296
P
N
G
K
D
Y
E
S
T
E
I
V
A
E
E
Site 35
S312
K
P
K
D
T
E
L
S
Q
E
S
D
F
K
E
Site 36
T323
D
F
K
E
N
G
I
T
E
E
K
S
K
S
E
Site 37
S327
N
G
I
T
E
E
K
S
K
S
E
E
S
K
R
Site 38
S329
I
T
E
E
K
S
K
S
E
E
S
K
R
M
E
Site 39
S332
E
K
S
K
S
E
E
S
K
R
M
E
P
I
A
Site 40
T353
E
I
S
E
F
D
V
T
K
S
K
N
V
P
K
Site 41
S355
S
E
F
D
V
T
K
S
K
N
V
P
K
Q
F
Site 42
T384
D
N
G
F
E
D
R
T
S
E
Q
Y
E
T
L
Site 43
S385
N
G
F
E
D
R
T
S
E
Q
Y
E
T
L
L
Site 44
Y388
E
D
R
T
S
E
Q
Y
E
T
L
L
I
E
T
Site 45
T390
R
T
S
E
Q
Y
E
T
L
L
I
E
T
A
S
Site 46
S417
Q
L
V
N
E
M
A
S
D
D
N
K
I
N
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation