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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACAT1
Full Name:
Acetyl-CoA acetyltransferase, mitochondrial
Alias:
ACAT; Acetoacetyl coenzyme A thiolase; Acetoacetyl-CoA thiolase; Acetyl-Coenzyme A acetyltransferase 1; Acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase); EC 2.3.1.9; MAT; T2; THIL
Type:
Enzyme - Acetyltransferase, Amino Acid Metabolism group
Mass (Da):
45200
Number AA:
427
UniProt ID:
P24752
International Prot ID:
IPI00030363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005743
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0003985
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
L
L
R
S
G
A
R
S
R
S
P
L
L
R
R
Site 2
S16
R
S
G
A
R
S
R
S
P
L
L
R
R
L
V
Site 3
Y28
R
L
V
Q
E
I
R
Y
V
E
R
S
Y
V
S
Site 4
S32
E
I
R
Y
V
E
R
S
Y
V
S
K
P
T
L
Site 5
Y33
I
R
Y
V
E
R
S
Y
V
S
K
P
T
L
K
Site 6
S58
P
I
G
S
F
L
G
S
L
S
L
L
P
A
T
Site 7
Y90
K
E
E
V
K
E
A
Y
M
G
N
V
L
Q
G
Site 8
S116
L
G
A
G
L
P
I
S
T
P
C
T
T
I
N
Site 9
T120
L
P
I
S
T
P
C
T
T
I
N
K
V
C
A
Site 10
T121
P
I
S
T
P
C
T
T
I
N
K
V
C
A
S
Site 11
S128
T
I
N
K
V
C
A
S
G
M
K
A
I
M
M
Site 12
S137
M
K
A
I
M
M
A
S
Q
S
L
M
C
G
H
Site 13
Y161
E
S
M
S
N
V
P
Y
V
M
N
R
G
S
T
Site 14
S167
P
Y
V
M
N
R
G
S
T
P
Y
G
G
V
K
Site 15
T168
Y
V
M
N
R
G
S
T
P
Y
G
G
V
K
L
Site 16
Y170
M
N
R
G
S
T
P
Y
G
G
V
K
L
E
D
Site 17
Y188
K
D
G
L
T
D
V
Y
N
K
I
H
M
G
S
Site 18
Y214
A
R
N
E
Q
D
A
Y
A
I
N
S
Y
T
R
Site 19
S218
Q
D
A
Y
A
I
N
S
Y
T
R
S
K
A
A
Site 20
Y219
D
A
Y
A
I
N
S
Y
T
R
S
K
A
A
W
Site 21
S222
A
I
N
S
Y
T
R
S
K
A
A
W
E
A
G
Site 22
Y256
V
V
K
E
D
E
E
Y
K
R
V
D
F
S
K
Site 23
S262
E
Y
K
R
V
D
F
S
K
V
P
K
L
K
T
Site 24
T269
S
K
V
P
K
L
K
T
V
F
Q
K
E
N
G
Site 25
Y331
D
F
P
I
A
P
V
Y
A
A
S
M
V
L
K
Site 26
Y407
H
A
L
K
Q
G
E
Y
G
L
A
S
I
C
N
Site 27
S411
Q
G
E
Y
G
L
A
S
I
C
N
G
G
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation