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Updated November 2019
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Protein Info
Short Name:
TNC
Full Name:
Tenascin
Alias:
Cytotactin; Glioma-associated-extracellular matrix antigen; GMEM; GP 150-225; Hexabrachion; Hexabrachion (tenascin); HXB; JI; MGC167029; Myotendinous antigen; Neuronectin; TENA; Tenascin C; Tenascin-C; TN; TN-C
Type:
Mass (Da):
240853
Number AA:
2201
UniProt ID:
P24821
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0009611
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
V
I
R
H
K
R
Q
S
G
V
N
A
T
L
P
Site 2
S62
N
I
K
L
P
V
G
S
Q
C
S
V
D
L
E
Site 3
S70
Q
C
S
V
D
L
E
S
A
S
G
E
K
D
L
Site 4
S72
S
V
D
L
E
S
A
S
G
E
K
D
L
A
P
Site 5
S81
E
K
D
L
A
P
P
S
E
P
S
E
S
F
Q
Site 6
S84
L
A
P
P
S
E
P
S
E
S
F
Q
E
H
T
Site 7
S86
P
P
S
E
P
S
E
S
F
Q
E
H
T
V
D
Site 8
T91
S
E
S
F
Q
E
H
T
V
D
G
E
N
Q
I
Site 9
S124
P
D
V
K
E
L
L
S
R
L
E
E
L
E
N
Site 10
S134
E
E
L
E
N
L
V
S
S
L
R
E
Q
C
T
Site 11
S135
E
L
E
N
L
V
S
S
L
R
E
Q
C
T
A
Site 12
T152
G
C
C
L
Q
P
A
T
G
R
L
D
T
R
P
Site 13
T157
P
A
T
G
R
L
D
T
R
P
F
C
S
G
R
Site 14
S162
L
D
T
R
P
F
C
S
G
R
G
N
F
S
T
Site 15
T169
S
G
R
G
N
F
S
T
E
G
C
G
C
V
C
Site 16
S217
G
F
T
G
E
D
C
S
Q
L
A
C
P
S
D
Site 17
S248
G
Y
A
G
A
D
C
S
R
E
I
C
P
V
P
Site 18
Y289
P
L
C
L
N
N
C
Y
N
R
G
R
C
V
E
Site 19
S373
G
F
A
G
L
D
C
S
E
K
R
C
P
A
D
Site 20
Y429
Q
C
V
C
D
E
G
Y
T
G
E
D
C
S
Q
Site 21
S435
G
Y
T
G
E
D
C
S
Q
L
R
C
P
N
D
Site 22
Y463
C
E
Q
G
F
K
G
Y
D
C
S
D
M
S
C
Site 23
Y491
M
C
V
C
D
D
G
Y
T
G
E
D
C
R
D
Site 24
S621
G
Y
S
G
E
D
C
S
E
V
S
P
P
K
D
Site 25
S624
G
E
D
C
S
E
V
S
P
P
K
D
L
V
V
Site 26
Y652
N
E
M
R
V
T
E
Y
L
V
V
Y
T
P
T
Site 27
Y656
V
T
E
Y
L
V
V
Y
T
P
T
H
E
G
G
Site 28
T657
T
E
Y
L
V
V
Y
T
P
T
H
E
G
G
L
Site 29
S676
R
V
P
G
D
Q
T
S
T
I
I
Q
E
L
E
Site 30
S705
N
K
K
S
I
P
V
S
A
R
V
A
T
Y
L
Site 31
S722
P
E
G
L
K
F
K
S
I
K
E
T
S
V
E
Site 32
T726
K
F
K
S
I
K
E
T
S
V
E
V
E
W
D
Site 33
S727
F
K
S
I
K
E
T
S
V
E
V
E
W
D
P
Site 34
T758
K
E
D
E
G
E
I
T
K
S
L
R
R
P
E
Site 35
S760
D
E
G
E
I
T
K
S
L
R
R
P
E
T
S
Site 36
T766
K
S
L
R
R
P
E
T
S
Y
R
Q
T
G
L
Site 37
S767
S
L
R
R
P
E
T
S
Y
R
Q
T
G
L
A
Site 38
Y768
L
R
R
P
E
T
S
Y
R
Q
T
G
L
A
P
Site 39
T771
P
E
T
S
Y
R
Q
T
G
L
A
P
G
Q
E
Site 40
S782
P
G
Q
E
Y
E
I
S
L
H
I
V
K
N
N
Site 41
T799
G
P
G
L
K
R
V
T
T
T
R
L
D
A
P
Site 42
T800
P
G
L
K
R
V
T
T
T
R
L
D
A
P
S
Site 43
S807
T
T
R
L
D
A
P
S
Q
I
E
V
K
D
V
Site 44
T847
K
D
V
P
G
D
R
T
T
I
D
L
T
E
D
Site 45
T848
D
V
P
G
D
R
T
T
I
D
L
T
E
D
E
Site 46
T852
D
R
T
T
I
D
L
T
E
D
E
N
Q
Y
S
Site 47
S859
T
E
D
E
N
Q
Y
S
I
G
N
L
K
P
D
Site 48
T867
I
G
N
L
K
P
D
T
E
Y
E
V
S
L
I
Site 49
Y869
N
L
K
P
D
T
E
Y
E
V
S
L
I
S
R
Site 50
S872
P
D
T
E
Y
E
V
S
L
I
S
R
R
G
D
Site 51
S875
E
Y
E
V
S
L
I
S
R
R
G
D
M
S
S
Site 52
S881
I
S
R
R
G
D
M
S
S
N
P
A
K
E
T
Site 53
S882
S
R
R
G
D
M
S
S
N
P
A
K
E
T
F
Site 54
T888
S
S
N
P
A
K
E
T
F
T
T
G
L
D
A
Site 55
T891
P
A
K
E
T
F
T
T
G
L
D
A
P
R
N
Site 56
S903
P
R
N
L
R
R
V
S
Q
T
D
N
S
I
T
Site 57
T905
N
L
R
R
V
S
Q
T
D
N
S
I
T
L
E
Site 58
S908
R
V
S
Q
T
D
N
S
I
T
L
E
W
R
N
Site 59
S922
N
G
K
A
A
I
D
S
Y
R
I
K
Y
A
P
Site 60
Y923
G
K
A
A
I
D
S
Y
R
I
K
Y
A
P
I
Site 61
Y927
I
D
S
Y
R
I
K
Y
A
P
I
S
G
G
D
Site 62
S931
R
I
K
Y
A
P
I
S
G
G
D
H
A
E
V
Site 63
S943
A
E
V
D
V
P
K
S
Q
Q
A
T
T
K
T
Site 64
T947
V
P
K
S
Q
Q
A
T
T
K
T
T
L
T
G
Site 65
T950
S
Q
Q
A
T
T
K
T
T
L
T
G
L
R
P
Site 66
S974
A
V
K
E
D
K
E
S
N
P
A
T
I
N
A
Site 67
T978
D
K
E
S
N
P
A
T
I
N
A
A
T
E
L
Site 68
T987
N
A
A
T
E
L
D
T
P
K
D
L
Q
V
S
Site 69
S994
T
P
K
D
L
Q
V
S
E
T
A
E
T
S
L
Site 70
T996
K
D
L
Q
V
S
E
T
A
E
T
S
L
T
L
Site 71
T999
Q
V
S
E
T
A
E
T
S
L
T
L
L
W
K
Site 72
S1000
V
S
E
T
A
E
T
S
L
T
L
L
W
K
T
Site 73
T1002
E
T
A
E
T
S
L
T
L
L
W
K
T
P
L
Site 74
T1007
S
L
T
L
L
W
K
T
P
L
A
K
F
D
R
Site 75
Y1015
P
L
A
K
F
D
R
Y
R
L
N
Y
S
L
P
Site 76
Y1019
F
D
R
Y
R
L
N
Y
S
L
P
T
G
Q
W
Site 77
S1020
D
R
Y
R
L
N
Y
S
L
P
T
G
Q
W
V
Site 78
T1035
G
V
Q
L
P
R
N
T
T
S
Y
V
L
R
G
Site 79
T1036
V
Q
L
P
R
N
T
T
S
Y
V
L
R
G
L
Site 80
Y1038
L
P
R
N
T
T
S
Y
V
L
R
G
L
E
P
Site 81
S1062
A
E
K
G
R
H
K
S
K
P
A
R
V
K
A
Site 82
T1071
P
A
R
V
K
A
S
T
E
Q
A
P
E
L
E
Site 83
T1081
A
P
E
L
E
N
L
T
V
T
E
V
G
W
D
Site 84
T1095
D
G
L
R
L
N
W
T
A
A
D
Q
A
Y
E
Site 85
S1125
R
N
L
T
V
P
G
S
L
R
A
V
D
I
P
Site 86
Y1145
T
P
Y
T
V
S
I
Y
G
V
I
Q
G
Y
R
Site 87
S1157
G
Y
R
T
P
V
L
S
A
E
A
S
T
G
E
Site 88
S1161
P
V
L
S
A
E
A
S
T
G
E
T
P
N
L
Site 89
T1165
A
E
A
S
T
G
E
T
P
N
L
G
E
V
V
Site 90
Y1194
A
P
E
G
A
Y
E
Y
F
F
I
Q
V
Q
E
Site 91
T1204
I
Q
V
Q
E
A
D
T
V
E
A
A
Q
N
L
Site 92
T1212
V
E
A
A
Q
N
L
T
V
P
G
G
L
R
S
Site 93
S1219
T
V
P
G
G
L
R
S
T
D
L
P
G
L
K
Site 94
T1220
V
P
G
G
L
R
S
T
D
L
P
G
L
K
A
Site 95
T1234
A
A
T
H
Y
T
I
T
I
R
G
V
T
Q
D
Site 96
T1239
T
I
T
I
R
G
V
T
Q
D
F
S
T
T
P
Site 97
S1243
R
G
V
T
Q
D
F
S
T
T
P
L
S
V
E
Site 98
S1248
D
F
S
T
T
P
L
S
V
E
V
L
T
E
E
Site 99
T1263
V
P
D
M
G
N
L
T
V
T
E
V
S
W
D
Site 100
T1277
D
A
L
R
L
N
W
T
T
P
D
G
T
Y
D
Site 101
T1278
A
L
R
L
N
W
T
T
P
D
G
T
Y
D
Q
Site 102
Y1283
W
T
T
P
D
G
T
Y
D
Q
F
T
I
Q
V
Site 103
T1287
D
G
T
Y
D
Q
F
T
I
Q
V
Q
E
A
D
Site 104
T1303
V
E
E
A
H
N
L
T
V
P
G
S
L
R
S
Site 105
S1307
H
N
L
T
V
P
G
S
L
R
S
M
E
I
P
Site 106
S1310
T
V
P
G
S
L
R
S
M
E
I
P
G
L
R
Site 107
Y1322
G
L
R
A
G
T
P
Y
T
V
T
L
H
G
E
Site 108
T1325
A
G
T
P
Y
T
V
T
L
H
G
E
V
R
G
Site 109
S1334
H
G
E
V
R
G
H
S
T
R
P
L
A
V
E
Site 110
T1368
D
G
L
R
L
N
W
T
A
A
D
N
A
Y
E
Site 111
T1394
V
E
A
A
Q
N
L
T
L
P
G
S
L
R
A
Site 112
S1398
Q
N
L
T
L
P
G
S
L
R
A
V
D
I
P
Site 113
Y1418
T
P
Y
R
V
S
I
Y
G
V
I
R
G
Y
R
Site 114
S1430
G
Y
R
T
P
V
L
S
A
E
A
S
T
A
K
Site 115
S1434
P
V
L
S
A
E
A
S
T
A
K
E
P
E
I
Site 116
S1447
E
I
G
N
L
N
V
S
D
I
T
P
E
S
F
Site 117
T1450
N
L
N
V
S
D
I
T
P
E
S
F
N
L
S
Site 118
S1453
V
S
D
I
T
P
E
S
F
N
L
S
W
M
A
Site 119
S1457
T
P
E
S
F
N
L
S
W
M
A
T
D
G
I
Site 120
T1481
D
S
N
R
L
L
E
T
V
E
Y
N
I
S
G
Site 121
Y1484
R
L
L
E
T
V
E
Y
N
I
S
G
A
E
R
Site 122
S1487
E
T
V
E
Y
N
I
S
G
A
E
R
T
A
H
Site 123
S1496
A
E
R
T
A
H
I
S
G
L
P
P
S
T
D
Site 124
S1514
Y
L
S
G
L
A
P
S
I
R
T
K
T
I
S
Site 125
T1519
A
P
S
I
R
T
K
T
I
S
A
T
A
T
T
Site 126
S1521
S
I
R
T
K
T
I
S
A
T
A
T
T
E
A
Site 127
T1576
L
L
D
P
Q
E
F
T
L
S
G
T
Q
R
K
Site 128
S1578
D
P
Q
E
F
T
L
S
G
T
Q
R
K
L
E
Site 129
T1580
Q
E
F
T
L
S
G
T
Q
R
K
L
E
L
R
Site 130
S1629
E
V
D
N
L
L
V
S
D
A
T
P
D
G
F
Site 131
T1632
N
L
L
V
S
D
A
T
P
D
G
F
R
L
S
Site 132
S1639
T
P
D
G
F
R
L
S
W
T
A
D
E
G
V
Site 133
T1641
D
G
F
R
L
S
W
T
A
D
E
G
V
F
D
Site 134
T1657
F
V
L
K
I
R
D
T
K
K
Q
S
E
P
L
Site 135
T1678
P
E
R
T
R
D
L
T
G
L
R
E
A
T
E
Site 136
T1684
L
T
G
L
R
E
A
T
E
Y
E
I
E
L
Y
Site 137
Y1686
G
L
R
E
A
T
E
Y
E
I
E
L
Y
G
I
Site 138
Y1691
T
E
Y
E
I
E
L
Y
G
I
S
K
G
R
R
Site 139
S1694
E
I
E
L
Y
G
I
S
K
G
R
R
S
Q
T
Site 140
S1699
G
I
S
K
G
R
R
S
Q
T
V
S
A
I
A
Site 141
T1701
S
K
G
R
R
S
Q
T
V
S
A
I
A
T
T
Site 142
S1703
G
R
R
S
Q
T
V
S
A
I
A
T
T
A
M
Site 143
S1719
S
P
K
E
V
I
F
S
D
I
T
E
N
S
A
Site 144
S1725
F
S
D
I
T
E
N
S
A
T
V
S
W
R
A
Site 145
T1727
D
I
T
E
N
S
A
T
V
S
W
R
A
P
T
Site 146
S1729
T
E
N
S
A
T
V
S
W
R
A
P
T
A
Q
Site 147
T1734
T
V
S
W
R
A
P
T
A
Q
V
E
S
F
R
Site 148
S1739
A
P
T
A
Q
V
E
S
F
R
I
T
Y
V
P
Site 149
T1751
Y
V
P
I
T
G
G
T
P
S
M
V
T
V
D
Site 150
T1756
G
G
T
P
S
M
V
T
V
D
G
T
K
T
Q
Site 151
T1760
S
M
V
T
V
D
G
T
K
T
Q
T
R
L
V
Site 152
T1762
V
T
V
D
G
T
K
T
Q
T
R
L
V
K
L
Site 153
S1788
A
M
K
G
F
E
E
S
E
P
V
S
G
S
F
Site 154
S1792
F
E
E
S
E
P
V
S
G
S
F
T
T
A
L
Site 155
S1794
E
S
E
P
V
S
G
S
F
T
T
A
L
D
G
Site 156
T1796
E
P
V
S
G
S
F
T
T
A
L
D
G
P
S
Site 157
T1807
D
G
P
S
G
L
V
T
A
N
I
T
D
S
E
Site 158
S1813
V
T
A
N
I
T
D
S
E
A
L
A
R
W
Q
Site 159
S1832
T
V
D
S
Y
V
I
S
Y
T
G
E
K
V
P
Site 160
T1842
G
E
K
V
P
E
I
T
R
T
V
S
G
N
T
Site 161
T1844
K
V
P
E
I
T
R
T
V
S
G
N
T
V
E
Site 162
S1846
P
E
I
T
R
T
V
S
G
N
T
V
E
Y
A
Site 163
T1855
N
T
V
E
Y
A
L
T
D
L
E
P
A
T
E
Site 164
T1864
L
E
P
A
T
E
Y
T
L
R
I
F
A
E
K
Site 165
S1876
A
E
K
G
P
Q
K
S
S
T
I
T
A
K
F
Site 166
T1878
K
G
P
Q
K
S
S
T
I
T
A
K
F
T
T
Site 167
T1880
P
Q
K
S
S
T
I
T
A
K
F
T
T
D
L
Site 168
T1885
T
I
T
A
K
F
T
T
D
L
D
S
P
R
D
Site 169
S1889
K
F
T
T
D
L
D
S
P
R
D
L
T
A
T
Site 170
T1894
L
D
S
P
R
D
L
T
A
T
E
V
Q
S
E
Site 171
T1896
S
P
R
D
L
T
A
T
E
V
Q
S
E
T
A
Site 172
T1902
A
T
E
V
Q
S
E
T
A
L
L
T
W
R
P
Site 173
T1906
Q
S
E
T
A
L
L
T
W
R
P
P
R
A
S
Site 174
S1913
T
W
R
P
P
R
A
S
V
T
G
Y
L
L
V
Site 175
S1923
G
Y
L
L
V
Y
E
S
V
D
G
T
V
K
E
Site 176
T1937
E
V
I
V
G
P
D
T
T
S
Y
S
L
A
D
Site 177
Y1940
V
G
P
D
T
T
S
Y
S
L
A
D
L
S
P
Site 178
S1941
G
P
D
T
T
S
Y
S
L
A
D
L
S
P
S
Site 179
S1946
S
Y
S
L
A
D
L
S
P
S
T
H
Y
T
A
Site 180
T1952
L
S
P
S
T
H
Y
T
A
K
I
Q
A
L
N
Site 181
T1999
D
T
T
S
G
L
Y
T
I
Y
L
N
G
D
K
Site 182
Y2001
T
S
G
L
Y
T
I
Y
L
N
G
D
K
A
Q
Site 183
Y2037
K
N
G
R
E
N
F
Y
Q
N
W
K
A
Y
A
Site 184
Y2043
F
Y
Q
N
W
K
A
Y
A
A
G
F
G
D
R
Site 185
Y2070
K
I
T
A
Q
G
Q
Y
E
L
R
V
D
L
R
Site 186
Y2087
G
E
T
A
F
A
V
Y
D
K
F
S
V
G
D
Site 187
S2091
F
A
V
Y
D
K
F
S
V
G
D
A
K
T
R
Site 188
Y2099
V
G
D
A
K
T
R
Y
K
L
K
V
E
G
Y
Site 189
T2109
K
V
E
G
Y
S
G
T
A
G
D
S
M
A
Y
Site 190
S2113
Y
S
G
T
A
G
D
S
M
A
Y
H
N
G
R
Site 191
Y2116
T
A
G
D
S
M
A
Y
H
N
G
R
S
F
S
Site 192
S2121
M
A
Y
H
N
G
R
S
F
S
T
F
D
K
D
Site 193
S2123
Y
H
N
G
R
S
F
S
T
F
D
K
D
T
D
Site 194
T2124
H
N
G
R
S
F
S
T
F
D
K
D
T
D
S
Site 195
T2129
F
S
T
F
D
K
D
T
D
S
A
I
T
N
C
Site 196
S2131
T
F
D
K
D
T
D
S
A
I
T
N
C
A
L
Site 197
T2134
K
D
T
D
S
A
I
T
N
C
A
L
S
Y
K
Site 198
S2189
A
E
M
K
L
R
P
S
N
F
R
N
L
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation