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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CYP2F1
Full Name:
Cytochrome P450 2F1
Alias:
CYPIIF1
Type:
Mass (Da):
55501
Number AA:
491
UniProt ID:
P24903
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
D
S
I
S
T
A
I
L
L
Site 2
T53
L
C
S
Q
D
M
L
T
S
L
T
K
L
S
K
Site 3
S54
C
S
Q
D
M
L
T
S
L
T
K
L
S
K
E
Site 4
S59
L
T
S
L
T
K
L
S
K
E
Y
G
S
M
Y
Site 5
Y66
S
K
E
Y
G
S
M
Y
T
V
H
L
G
P
R
Site 6
T67
K
E
Y
G
S
M
Y
T
V
H
L
G
P
R
R
Site 7
S79
P
R
R
V
V
V
L
S
G
Y
Q
A
V
K
E
Site 8
S96
V
D
Q
G
E
E
F
S
G
R
G
D
Y
P
A
Site 9
Y101
E
F
S
G
R
G
D
Y
P
A
F
F
N
F
T
Site 10
S116
K
G
N
G
I
A
F
S
S
G
D
R
W
K
V
Site 11
S117
G
N
G
I
A
F
S
S
G
D
R
W
K
V
L
Site 12
S128
W
K
V
L
R
Q
F
S
I
Q
I
L
R
N
F
Site 13
S141
N
F
G
M
G
K
R
S
I
E
E
R
I
L
E
Site 14
S151
E
R
I
L
E
E
G
S
F
L
L
A
E
L
R
Site 15
T160
L
L
A
E
L
R
K
T
E
G
E
P
F
D
P
Site 16
T168
E
G
E
P
F
D
P
T
F
V
L
S
R
S
V
Site 17
Y190
L
F
G
S
R
F
D
Y
D
D
E
R
L
L
T
Site 18
T197
Y
D
D
E
R
L
L
T
I
I
R
L
I
N
D
Site 19
S248
L
R
D
L
I
A
H
S
V
H
D
H
Q
A
S
Site 20
S255
S
V
H
D
H
Q
A
S
L
D
P
R
S
P
R
Site 21
S260
Q
A
S
L
D
P
R
S
P
R
D
F
I
Q
C
Site 22
S281
E
E
K
E
D
P
L
S
H
F
H
M
D
T
L
Site 23
T287
L
S
H
F
H
M
D
T
L
L
M
T
T
H
N
Site 24
S304
F
G
G
T
K
T
V
S
T
T
L
H
H
A
F
Site 25
Y348
K
D
R
A
A
M
P
Y
T
D
A
V
I
H
E
Site 26
T349
D
R
A
A
M
P
Y
T
D
A
V
I
H
E
V
Site 27
T372
M
N
L
P
H
R
V
T
R
D
T
A
F
R
G
Site 28
T375
P
H
R
V
T
R
D
T
A
F
R
G
F
L
I
Site 29
T394
D
V
I
T
L
L
N
T
V
H
Y
D
P
S
Q
Site 30
Y397
T
L
L
N
T
V
H
Y
D
P
S
Q
F
L
T
Site 31
S400
N
T
V
H
Y
D
P
S
Q
F
L
T
P
Q
E
Site 32
T404
Y
D
P
S
Q
F
L
T
P
Q
E
F
N
P
E
Site 33
S419
H
F
L
D
A
N
Q
S
F
K
K
S
P
A
F
Site 34
S423
A
N
Q
S
F
K
K
S
P
A
F
M
P
F
S
Site 35
T471
A
P
E
D
I
D
L
T
P
L
S
S
G
L
G
Site 36
S475
I
D
L
T
P
L
S
S
G
L
G
N
L
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation