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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
F2R
Full Name:
Proteinase-activated receptor 1
Alias:
CF2R; Coagulation factor II (thrombin) receptor; Coagulation factor II receptor; PAR-1; Proteinase activated receptor 1 precursor; Thrombin receptor; TR
Type:
G protein-coupled 7TM receptor
Mass (Da):
47441
Number AA:
425
UniProt ID:
P25116
International Prot ID:
IPI00296869
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005901
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005102
GO:0015057
PhosphoSite+
KinaseNET
Biological Process:
GO:0007262
GO:0006919
GO:0009653
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
S
L
C
G
P
L
L
S
A
R
T
R
A
R
R
Site 2
T24
G
P
L
L
S
A
R
T
R
A
R
R
P
E
S
Site 3
S31
T
R
A
R
R
P
E
S
K
A
T
N
A
T
L
Site 4
T34
R
R
P
E
S
K
A
T
N
A
T
L
D
P
R
Site 5
T37
E
S
K
A
T
N
A
T
L
D
P
R
S
F
L
Site 6
S42
N
A
T
L
D
P
R
S
F
L
L
R
N
P
N
Site 7
Y52
L
R
N
P
N
D
K
Y
E
P
F
W
E
D
E
Site 8
S64
E
D
E
E
K
N
E
S
G
L
T
E
Y
R
L
Site 9
T67
E
K
N
E
S
G
L
T
E
Y
R
L
V
S
I
Site 10
Y69
N
E
S
G
L
T
E
Y
R
L
V
S
I
N
K
Site 11
S73
L
T
E
Y
R
L
V
S
I
N
K
S
S
P
L
Site 12
S77
R
L
V
S
I
N
K
S
S
P
L
Q
K
Q
L
Site 13
S78
L
V
S
I
N
K
S
S
P
L
Q
K
Q
L
P
Site 14
S89
K
Q
L
P
A
F
I
S
E
D
A
S
G
Y
L
Site 15
S93
A
F
I
S
E
D
A
S
G
Y
L
T
S
S
W
Site 16
Y95
I
S
E
D
A
S
G
Y
L
T
S
S
W
L
T
Site 17
T97
E
D
A
S
G
Y
L
T
S
S
W
L
T
L
F
Site 18
Y140
V
K
K
P
A
V
V
Y
M
L
H
L
A
T
A
Site 19
S160
S
V
L
P
F
K
I
S
Y
Y
F
S
G
S
D
Site 20
Y161
V
L
P
F
K
I
S
Y
Y
F
S
G
S
D
W
Site 21
Y162
L
P
F
K
I
S
Y
Y
F
S
G
S
D
W
Q
Site 22
Y206
D
R
F
L
A
V
V
Y
P
M
Q
S
L
S
W
Site 23
S212
V
Y
P
M
Q
S
L
S
W
R
T
L
G
R
A
Site 24
S300
I
I
R
C
L
S
S
S
A
V
A
N
R
S
K
Site 25
S306
S
S
A
V
A
N
R
S
K
K
S
R
A
L
F
Site 26
S309
V
A
N
R
S
K
K
S
R
A
L
F
L
S
A
Site 27
S341
I
A
H
Y
S
F
L
S
H
T
S
T
T
E
A
Site 28
T345
S
F
L
S
H
T
S
T
T
E
A
A
Y
F
A
Site 29
Y372
C
I
D
P
L
I
Y
Y
Y
A
S
S
E
C
Q
Site 30
Y373
I
D
P
L
I
Y
Y
Y
A
S
S
E
C
Q
R
Site 31
S375
P
L
I
Y
Y
Y
A
S
S
E
C
Q
R
Y
V
Site 32
S376
L
I
Y
Y
Y
A
S
S
E
C
Q
R
Y
V
Y
Site 33
Y383
S
E
C
Q
R
Y
V
Y
S
I
L
C
C
K
E
Site 34
S384
E
C
Q
R
Y
V
Y
S
I
L
C
C
K
E
S
Site 35
S391
S
I
L
C
C
K
E
S
S
D
P
S
S
Y
N
Site 36
S392
I
L
C
C
K
E
S
S
D
P
S
S
Y
N
S
Site 37
S395
C
K
E
S
S
D
P
S
S
Y
N
S
S
G
Q
Site 38
S396
K
E
S
S
D
P
S
S
Y
N
S
S
G
Q
L
Site 39
Y397
E
S
S
D
P
S
S
Y
N
S
S
G
Q
L
M
Site 40
S399
S
D
P
S
S
Y
N
S
S
G
Q
L
M
A
S
Site 41
S400
D
P
S
S
Y
N
S
S
G
Q
L
M
A
S
K
Site 42
S406
S
S
G
Q
L
M
A
S
K
M
D
T
C
S
S
Site 43
T410
L
M
A
S
K
M
D
T
C
S
S
N
L
N
N
Site 44
S412
A
S
K
M
D
T
C
S
S
N
L
N
N
S
I
Site 45
S413
S
K
M
D
T
C
S
S
N
L
N
N
S
I
Y
Site 46
S418
C
S
S
N
L
N
N
S
I
Y
K
K
L
L
T
Site 47
Y420
S
N
L
N
N
S
I
Y
K
K
L
L
T
_
_
Site 48
T425
S
I
Y
K
K
L
L
T
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation