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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX6
Full Name:
Probable ATP-dependent RNA helicase DDX6
Alias:
ATP-dependent RNA helicase DDX6; ATP-dependent RNA helicase p54; EC 3.6.1.-; HLR2; Oncogene RCK; P54; RCK; RCK oncogene
Type:
Helicase; EC 3.6.1.-; RNA processing; RNA binding protein
Mass (Da):
54417
Number AA:
483
UniProt ID:
P26196
International Prot ID:
IPI00030320
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
GO:0010494
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
P
V
I
M
G
L
S
S
Q
N
G
Q
L
R
G
Site 2
T28
L
R
G
P
V
K
P
T
G
G
P
G
G
G
G
Site 3
T36
G
G
P
G
G
G
G
T
Q
T
Q
Q
Q
M
N
Site 4
T38
P
G
G
G
G
T
Q
T
Q
Q
Q
M
N
Q
L
Site 5
T65
Q
A
Q
S
M
T
T
T
I
K
P
G
D
D
W
Site 6
T75
P
G
D
D
W
K
K
T
L
K
L
P
P
K
D
Site 7
T87
P
K
D
L
R
I
K
T
S
D
V
T
S
T
K
Site 8
S88
K
D
L
R
I
K
T
S
D
V
T
S
T
K
G
Site 9
T91
R
I
K
T
S
D
V
T
S
T
K
G
N
E
F
Site 10
S92
I
K
T
S
D
V
T
S
T
K
G
N
E
F
E
Site 11
Y101
K
G
N
E
F
E
D
Y
C
L
K
R
E
L
L
Site 12
S120
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
Site 13
S126
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
G
Site 14
T144
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
Site 15
S147
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
Site 16
Y150
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
Site 17
T199
G
G
A
K
V
M
A
T
T
G
G
T
N
L
R
Site 18
T203
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
Site 19
T222
T
V
H
V
V
I
A
T
P
G
R
I
L
D
L
Site 20
S253
D
E
A
D
K
L
L
S
Q
D
F
V
Q
I
M
Site 21
Y276
K
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
Site 22
S283
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
Site 23
Y312
T
L
K
G
V
T
Q
Y
Y
A
Y
V
T
E
R
Site 24
Y313
L
K
G
V
T
Q
Y
Y
A
Y
V
T
E
R
Q
Site 25
Y315
G
V
T
Q
Y
Y
A
Y
V
T
E
R
Q
K
V
Site 26
T317
T
Q
Y
Y
A
Y
V
T
E
R
Q
K
V
H
C
Site 27
T327
Q
K
V
H
C
L
N
T
L
F
S
R
L
Q
I
Site 28
S330
H
C
L
N
T
L
F
S
R
L
Q
I
N
Q
S
Site 29
S337
S
R
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Site 30
Y359
K
K
I
S
Q
L
G
Y
S
C
F
Y
I
H
A
Site 31
Y418
F
P
K
L
A
E
T
Y
L
H
R
I
G
R
S
Site 32
S425
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
Site 33
Y440
L
A
I
N
L
I
T
Y
D
D
R
F
N
L
K
Site 34
S448
D
D
R
F
N
L
K
S
I
E
E
Q
L
G
T
Site 35
T455
S
I
E
E
Q
L
G
T
E
I
K
P
I
P
S
Site 36
S462
T
E
I
K
P
I
P
S
N
I
D
K
S
L
Y
Site 37
S467
I
P
S
N
I
D
K
S
L
Y
V
A
E
Y
H
Site 38
Y469
S
N
I
D
K
S
L
Y
V
A
E
Y
H
S
E
Site 39
Y473
K
S
L
Y
V
A
E
Y
H
S
E
P
V
E
D
Site 40
S475
L
Y
V
A
E
Y
H
S
E
P
V
E
D
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation