KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DNMT1
Full Name:
DNA (cytosine-5)-methyltransferase 1
Alias:
CXXC9; CXXC-type zinc finger protein 9; DNA (cytosine-5-)-methyltransferase 1; DNA methyltransferase HsaI; DNA MTase HsaI; DNMT; MCMT
Type:
Cell development/differentiation; Amino Acid Metabolism - cysteine and methionine; Transcription regulation; Methyltransferase; EC 2.1.1.37
Mass (Da):
183165
Number AA:
1616
UniProt ID:
P26358
International Prot ID:
IPI00031519
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003886
GO:0003677
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0010216
GO:0051573
Phosida
TranscriptoNet
STRING
Kinexus Products
DNA (cytosine-5)-methyltransferase 1 pan-specific antibody AB-NN241-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN241-1#DNA (cytosine-5)-methyltransferase 1 pan-specific antibody AB-NN241-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN241-2#DNA (cytosine-5)-methyltransferase 1 pan-specific antibody AB-NN241-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN241-3
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
T
L
A
V
P
A
I
S
L
P
D
D
V
R
R
Site 2
S35
L
K
D
L
E
R
D
S
L
T
E
K
E
C
V
Site 3
T55
L
L
H
E
F
L
Q
T
E
I
K
N
Q
L
C
Site 4
T66
N
Q
L
C
D
L
E
T
K
L
R
K
E
E
L
Site 5
S74
K
L
R
K
E
E
L
S
E
E
G
Y
L
A
K
Site 6
Y78
E
E
L
S
E
E
G
Y
L
A
K
V
K
S
L
Site 7
S84
G
Y
L
A
K
V
K
S
L
L
N
K
D
L
S
Site 8
S91
S
L
L
N
K
D
L
S
L
E
N
G
A
H
A
Site 9
Y99
L
E
N
G
A
H
A
Y
N
R
E
V
N
G
R
Site 10
S115
E
N
G
N
Q
A
R
S
E
A
R
R
V
G
M
Site 11
S127
V
G
M
A
D
A
N
S
P
P
K
P
L
S
K
Site 12
S133
N
S
P
P
K
P
L
S
K
P
R
T
P
R
R
Site 13
T137
K
P
L
S
K
P
R
T
P
R
R
S
K
S
D
Site 14
S141
K
P
R
T
P
R
R
S
K
S
D
G
E
A
K
Site 15
S143
R
T
P
R
R
S
K
S
D
G
E
A
K
P
E
Site 16
S152
G
E
A
K
P
E
P
S
P
S
P
R
I
T
R
Site 17
S154
A
K
P
E
P
S
P
S
P
R
I
T
R
K
S
Site 18
T158
P
S
P
S
P
R
I
T
R
K
S
T
R
Q
T
Site 19
S161
S
P
R
I
T
R
K
S
T
R
Q
T
T
I
T
Site 20
T162
P
R
I
T
R
K
S
T
R
Q
T
T
I
T
S
Site 21
T165
T
R
K
S
T
R
Q
T
T
I
T
S
H
F
A
Site 22
T166
R
K
S
T
R
Q
T
T
I
T
S
H
F
A
K
Site 23
T168
S
T
R
Q
T
T
I
T
S
H
F
A
K
G
P
Site 24
S169
T
R
Q
T
T
I
T
S
H
F
A
K
G
P
A
Site 25
S184
K
R
K
P
Q
E
E
S
E
R
A
K
S
D
E
Site 26
S189
E
E
S
E
R
A
K
S
D
E
S
I
K
E
E
Site 27
S192
E
R
A
K
S
D
E
S
I
K
E
E
D
K
D
Site 28
T208
D
E
K
R
R
R
V
T
S
R
E
R
V
A
R
Site 29
S209
E
K
R
R
R
V
T
S
R
E
R
V
A
R
P
Site 30
S227
E
E
P
E
R
A
K
S
G
T
R
T
E
K
E
Site 31
T231
R
A
K
S
G
T
R
T
E
K
E
E
E
R
D
Site 32
S247
K
E
E
K
R
L
R
S
Q
T
K
E
P
T
P
Site 33
T249
E
K
R
L
R
S
Q
T
K
E
P
T
P
K
Q
Site 34
T253
R
S
Q
T
K
E
P
T
P
K
Q
K
L
K
E
Site 35
S288
K
D
E
K
K
H
R
S
Q
P
K
D
L
A
A
Site 36
S312
E
K
V
N
P
Q
I
S
D
E
K
D
E
D
E
Site 37
T327
K
E
E
K
R
R
K
T
T
P
K
E
P
T
E
Site 38
T328
E
E
K
R
R
K
T
T
P
K
E
P
T
E
K
Site 39
T342
K
K
M
A
R
A
K
T
V
M
N
S
K
T
H
Site 40
S346
R
A
K
T
V
M
N
S
K
T
H
P
P
K
C
Site 41
T348
K
T
V
M
N
S
K
T
H
P
P
K
C
I
Q
Site 42
Y359
K
C
I
Q
C
G
Q
Y
L
D
D
P
D
L
K
Site 43
Y367
L
D
D
P
D
L
K
Y
G
Q
H
P
P
D
A
Site 44
T382
V
D
E
P
Q
M
L
T
N
E
K
L
S
I
F
Site 45
S394
S
I
F
D
A
N
E
S
G
F
E
S
Y
E
A
Site 46
S398
A
N
E
S
G
F
E
S
Y
E
A
L
P
Q
H
Site 47
Y399
N
E
S
G
F
E
S
Y
E
A
L
P
Q
H
K
Site 48
S436
K
N
I
E
L
F
F
S
G
S
A
K
P
I
Y
Site 49
S438
I
E
L
F
F
S
G
S
A
K
P
I
Y
D
D
Site 50
Y443
S
G
S
A
K
P
I
Y
D
D
D
P
S
L
E
Site 51
S448
P
I
Y
D
D
D
P
S
L
E
G
G
V
N
G
Site 52
S492
E
Y
I
L
M
D
P
S
P
E
Y
A
P
I
F
Site 53
S509
M
Q
E
K
I
Y
I
S
K
I
V
V
E
F
L
Site 54
S518
I
V
V
E
F
L
Q
S
N
S
D
S
T
Y
E
Site 55
S520
V
E
F
L
Q
S
N
S
D
S
T
Y
E
D
L
Site 56
S522
F
L
Q
S
N
S
D
S
T
Y
E
D
L
I
N
Site 57
T523
L
Q
S
N
S
D
S
T
Y
E
D
L
I
N
K
Site 58
Y524
Q
S
N
S
D
S
T
Y
E
D
L
I
N
K
I
Site 59
T534
L
I
N
K
I
E
T
T
V
P
P
S
G
L
N
Site 60
S538
I
E
T
T
V
P
P
S
G
L
N
L
N
R
F
Site 61
T546
G
L
N
L
N
R
F
T
E
D
S
L
L
R
H
Site 62
S549
L
N
R
F
T
E
D
S
L
L
R
H
A
Q
F
Site 63
S563
F
V
V
E
Q
V
E
S
Y
D
E
A
G
D
S
Site 64
Y564
V
V
E
Q
V
E
S
Y
D
E
A
G
D
S
D
Site 65
S570
S
Y
D
E
A
G
D
S
D
E
Q
P
I
F
L
Site 66
T591
L
I
K
L
A
G
V
T
L
G
Q
R
R
A
Q
Site 67
T603
R
A
Q
A
R
R
Q
T
I
R
H
S
T
R
E
Site 68
S607
R
R
Q
T
I
R
H
S
T
R
E
K
D
R
G
Site 69
T608
R
Q
T
I
R
H
S
T
R
E
K
D
R
G
P
Site 70
T616
R
E
K
D
R
G
P
T
K
A
T
T
T
K
L
Site 71
S679
D
M
V
K
F
G
G
S
G
R
S
K
Q
A
C
Site 72
S714
D
N
I
P
E
M
P
S
P
K
K
M
H
Q
G
Site 73
S732
K
Q
N
K
N
R
I
S
W
V
G
E
A
V
K
Site 74
T740
W
V
G
E
A
V
K
T
D
G
K
K
S
Y
Y
Site 75
Y746
K
T
D
G
K
K
S
Y
Y
K
K
V
C
I
D
Site 76
S771
S
V
I
P
D
D
S
S
K
P
L
Y
L
A
R
Site 77
Y775
D
D
S
S
K
P
L
Y
L
A
R
V
T
A
L
Site 78
T780
P
L
Y
L
A
R
V
T
A
L
W
E
D
S
S
Site 79
S826
E
C
E
D
M
Q
L
S
Y
I
H
S
K
V
K
Site 80
Y836
H
S
K
V
K
V
I
Y
K
A
P
S
E
N
W
Site 81
S853
E
G
G
M
D
P
E
S
L
L
E
G
D
D
G
Site 82
Y863
E
G
D
D
G
K
T
Y
F
Y
Q
L
W
Y
D
Site 83
Y865
D
D
G
K
T
Y
F
Y
Q
L
W
Y
D
Q
D
Site 84
Y873
Q
L
W
Y
D
Q
D
Y
A
R
F
E
S
P
P
Site 85
S878
Q
D
Y
A
R
F
E
S
P
P
K
T
Q
P
T
Site 86
T882
R
F
E
S
P
P
K
T
Q
P
T
E
D
N
K
Site 87
S919
E
Q
L
E
D
L
D
S
R
V
L
Y
Y
S
A
Site 88
Y923
D
L
D
S
R
V
L
Y
Y
S
A
T
K
N
G
Site 89
S925
D
S
R
V
L
Y
Y
S
A
T
K
N
G
I
L
Site 90
T927
R
V
L
Y
Y
S
A
T
K
N
G
I
L
Y
R
Site 91
Y933
A
T
K
N
G
I
L
Y
R
V
G
D
G
V
Y
Site 92
Y940
Y
R
V
G
D
G
V
Y
L
P
P
E
A
F
T
Site 93
T947
Y
L
P
P
E
A
F
T
F
N
I
K
L
S
S
Site 94
S953
F
T
F
N
I
K
L
S
S
P
V
K
R
P
R
Site 95
S954
T
F
N
I
K
L
S
S
P
V
K
R
P
R
K
Site 96
Y969
E
P
V
D
E
D
L
Y
P
E
H
Y
R
K
Y
Site 97
Y973
E
D
L
Y
P
E
H
Y
R
K
Y
S
D
Y
I
Site 98
Y976
Y
P
E
H
Y
R
K
Y
S
D
Y
I
K
G
S
Site 99
S977
P
E
H
Y
R
K
Y
S
D
Y
I
K
G
S
N
Site 100
Y979
H
Y
R
K
Y
S
D
Y
I
K
G
S
N
L
D
Site 101
S983
Y
S
D
Y
I
K
G
S
N
L
D
A
P
E
P
Site 102
S1005
E
I
F
C
P
K
K
S
N
G
R
P
N
E
T
Site 103
Y1022
K
I
R
V
N
K
F
Y
R
P
E
N
T
H
K
Site 104
T1027
K
F
Y
R
P
E
N
T
H
K
S
T
P
A
S
Site 105
S1030
R
P
E
N
T
H
K
S
T
P
A
S
Y
H
A
Site 106
T1031
P
E
N
T
H
K
S
T
P
A
S
Y
H
A
D
Site 107
S1034
T
H
K
S
T
P
A
S
Y
H
A
D
I
N
L
Site 108
Y1043
H
A
D
I
N
L
L
Y
W
S
D
E
E
A
V
Site 109
S1045
D
I
N
L
L
Y
W
S
D
E
E
A
V
V
D
Site 110
T1061
K
A
V
Q
G
R
C
T
V
E
Y
G
E
D
L
Site 111
Y1064
Q
G
R
C
T
V
E
Y
G
E
D
L
P
E
C
Site 112
Y1075
L
P
E
C
V
Q
V
Y
S
M
G
G
P
N
R
Site 113
Y1084
M
G
G
P
N
R
F
Y
F
L
E
A
Y
N
A
Site 114
Y1089
R
F
Y
F
L
E
A
Y
N
A
K
S
K
S
F
Site 115
S1093
L
E
A
Y
N
A
K
S
K
S
F
E
D
P
P
Site 116
S1095
A
Y
N
A
K
S
K
S
F
E
D
P
P
N
H
Site 117
S1105
D
P
P
N
H
A
R
S
P
G
N
K
G
K
G
Site 118
S1122
K
G
K
G
K
P
K
S
Q
A
C
E
P
S
E
Site 119
S1128
K
S
Q
A
C
E
P
S
E
P
E
I
E
I
K
Site 120
S1152
F
S
G
C
G
G
L
S
E
G
F
H
Q
A
G
Site 121
S1184
F
R
L
N
N
P
G
S
T
V
F
T
E
D
C
Site 122
T1204
L
V
M
A
G
E
T
T
N
S
R
G
Q
R
L
Site 123
S1206
M
A
G
E
T
T
N
S
R
G
Q
R
L
P
Q
Site 124
S1237
S
G
M
N
R
F
N
S
R
T
Y
S
K
F
K
Site 125
T1239
M
N
R
F
N
S
R
T
Y
S
K
F
K
N
S
Site 126
Y1240
N
R
F
N
S
R
T
Y
S
K
F
K
N
S
L
Site 127
S1241
R
F
N
S
R
T
Y
S
K
F
K
N
S
L
V
Site 128
S1246
T
Y
S
K
F
K
N
S
L
V
V
S
F
L
S
Site 129
S1250
F
K
N
S
L
V
V
S
F
L
S
Y
C
D
Y
Site 130
Y1254
L
V
V
S
F
L
S
Y
C
D
Y
Y
R
P
R
Site 131
Y1257
S
F
L
S
Y
C
D
Y
Y
R
P
R
F
F
L
Site 132
S1273
E
N
V
R
N
F
V
S
F
K
R
S
M
V
L
Site 133
T1309
G
Q
Y
G
V
A
Q
T
R
R
R
A
I
I
L
Site 134
S1342
A
P
R
A
C
Q
L
S
V
V
V
D
D
K
K
Site 135
S1352
V
D
D
K
K
F
V
S
N
I
T
R
L
S
S
Site 136
S1358
V
S
N
I
T
R
L
S
S
G
P
F
R
T
I
Site 137
S1359
S
N
I
T
R
L
S
S
G
P
F
R
T
I
T
Site 138
T1364
L
S
S
G
P
F
R
T
I
T
V
R
D
T
M
Site 139
T1366
S
G
P
F
R
T
I
T
V
R
D
T
M
S
D
Site 140
T1370
R
T
I
T
V
R
D
T
M
S
D
L
P
E
V
Site 141
S1372
I
T
V
R
D
T
M
S
D
L
P
E
V
R
N
Site 142
S1394
S
Y
N
G
E
P
Q
S
W
F
Q
R
Q
L
R
Site 143
Y1405
R
Q
L
R
G
A
Q
Y
Q
P
I
L
R
D
H
Site 144
S1418
D
H
I
C
K
D
M
S
A
L
V
A
A
R
M
Site 145
S1434
H
I
P
L
A
P
G
S
D
W
R
D
L
P
N
Site 146
S1447
P
N
I
E
V
R
L
S
D
G
T
M
A
R
K
Site 147
T1450
E
V
R
L
S
D
G
T
M
A
R
K
L
R
Y
Site 148
T1458
M
A
R
K
L
R
Y
T
H
H
D
R
K
N
G
Site 149
S1467
H
D
R
K
N
G
R
S
S
S
G
A
L
R
G
Site 150
S1468
D
R
K
N
G
R
S
S
S
G
A
L
R
G
V
Site 151
S1469
R
K
N
G
R
S
S
S
G
A
L
R
G
V
C
Site 152
Y1514
H
N
H
W
A
G
L
Y
G
R
L
E
W
D
G
Site 153
T1526
W
D
G
F
F
S
T
T
V
T
N
P
E
P
M
Site 154
T1528
G
F
F
S
T
T
V
T
N
P
E
P
M
G
K
Site 155
S1549
P
E
Q
H
R
V
V
S
V
R
E
C
A
R
S
Site 156
S1556
S
V
R
E
C
A
R
S
Q
G
F
P
D
T
Y
Site 157
T1562
R
S
Q
G
F
P
D
T
Y
R
L
F
G
N
I
Site 158
Y1563
S
Q
G
F
P
D
T
Y
R
L
F
G
N
I
L
Site 159
S1603
M
L
A
K
A
R
E
S
A
S
A
K
I
K
E
Site 160
S1605
A
K
A
R
E
S
A
S
A
K
I
K
E
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation