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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PON1
Full Name:
Serum paraoxonase/arylesterase 1
Alias:
Aromatic esterase 1;K-45;Serum aryldialkylphosphatase 1
Type:
Mass (Da):
39749
Number AA:
355
UniProt ID:
P27169
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
L
F
R
N
H
Q
S
S
Y
Q
T
R
L
N
A
Site 2
S52
V
K
G
I
E
T
G
S
E
D
M
E
I
L
P
Site 3
S66
P
N
G
L
A
F
I
S
S
G
L
K
Y
P
G
Site 4
Y71
F
I
S
S
G
L
K
Y
P
G
I
K
S
F
N
Site 5
S76
L
K
Y
P
G
I
K
S
F
N
P
N
S
P
G
Site 6
S81
I
K
S
F
N
P
N
S
P
G
K
I
L
L
M
Site 7
T96
D
L
N
E
E
D
P
T
V
L
E
L
G
I
T
Site 8
S110
T
G
S
K
F
D
V
S
S
F
N
P
H
G
I
Site 9
S111
G
S
K
F
D
V
S
S
F
N
P
H
G
I
S
Site 10
T119
F
N
P
H
G
I
S
T
F
T
D
E
D
N
A
Site 11
Y128
T
D
E
D
N
A
M
Y
L
L
V
V
N
H
P
Site 12
S139
V
N
H
P
D
A
K
S
T
V
E
L
F
K
F
Site 13
S152
K
F
Q
E
E
E
K
S
L
L
H
L
K
T
I
Site 14
T158
K
S
L
L
H
L
K
T
I
R
H
K
L
L
P
Site 15
Y179
A
V
G
P
E
H
F
Y
G
T
N
D
H
Y
F
Site 16
Y185
F
Y
G
T
N
D
H
Y
F
L
D
P
Y
L
Q
Site 17
Y190
D
H
Y
F
L
D
P
Y
L
Q
S
W
E
M
Y
Site 18
Y197
Y
L
Q
S
W
E
M
Y
L
G
L
A
W
S
Y
Site 19
Y207
L
A
W
S
Y
V
V
Y
Y
S
P
S
E
V
R
Site 20
S229
F
A
N
G
I
N
I
S
P
D
G
K
Y
V
Y
Site 21
Y236
S
P
D
G
K
Y
V
Y
I
A
E
L
L
A
H
Site 22
T257
K
H
A
N
W
T
L
T
P
L
K
S
L
D
F
Site 23
S272
N
T
L
V
D
N
I
S
V
D
P
E
T
G
D
Site 24
T277
N
I
S
V
D
P
E
T
G
D
L
W
V
G
C
Site 25
Y294
N
G
M
K
I
F
F
Y
D
S
E
N
P
P
A
Site 26
S296
M
K
I
F
F
Y
D
S
E
N
P
P
A
S
E
Site 27
S302
D
S
E
N
P
P
A
S
E
V
L
R
I
Q
N
Site 28
T312
L
R
I
Q
N
I
L
T
E
E
P
K
V
T
Q
Site 29
T318
L
T
E
E
P
K
V
T
Q
V
Y
A
E
N
G
Site 30
Y321
E
P
K
V
T
Q
V
Y
A
E
N
G
T
V
L
Site 31
T326
Q
V
Y
A
E
N
G
T
V
L
Q
G
S
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation