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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RPA1
Full Name:
Replication protein A 70 kDa DNA-binding subunit
Alias:
HSSB; REPA1; Replication factor A protein 1; RF-A; RFA1; RP-A; RPA70; Single-stranded DNA-binding protein
Type:
DNA binding protein
Mass (Da):
68138
Number AA:
616
UniProt ID:
P27694
International Prot ID:
IPI00020127
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000793
GO:0005634
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0000718
GO:0006139
GO:0006259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
V
G
Q
L
S
E
G
A
I
A
A
I
Site 2
T34
V
I
N
I
R
P
I
T
T
G
N
S
P
P
R
Site 3
T35
I
N
I
R
P
I
T
T
G
N
S
P
P
R
Y
Site 4
S38
R
P
I
T
T
G
N
S
P
P
R
Y
R
L
L
Site 5
Y42
T
G
N
S
P
P
R
Y
R
L
L
M
S
D
G
Site 6
T52
L
M
S
D
G
L
N
T
L
S
S
F
M
L
A
Site 7
T86
I
H
R
F
I
V
N
T
L
K
D
G
R
R
V
Site 8
Y118
K
I
G
N
P
V
P
Y
N
E
G
L
G
Q
P
Site 9
S135
A
P
P
A
P
A
A
S
P
A
A
S
S
R
P
Site 10
S139
P
A
A
S
P
A
A
S
S
R
P
Q
P
Q
N
Site 11
S148
R
P
Q
P
Q
N
G
S
S
G
M
G
S
T
V
Site 12
S149
P
Q
P
Q
N
G
S
S
G
M
G
S
T
V
S
Site 13
S153
N
G
S
S
G
M
G
S
T
V
S
K
A
Y
G
Site 14
T154
G
S
S
G
M
G
S
T
V
S
K
A
Y
G
A
Site 15
S156
S
G
M
G
S
T
V
S
K
A
Y
G
A
S
K
Site 16
T164
K
A
Y
G
A
S
K
T
F
G
K
A
A
G
P
Site 17
S172
F
G
K
A
A
G
P
S
L
S
H
T
S
G
G
Site 18
S174
K
A
A
G
P
S
L
S
H
T
S
G
G
T
Q
Site 19
T176
A
G
P
S
L
S
H
T
S
G
G
T
Q
S
K
Site 20
S177
G
P
S
L
S
H
T
S
G
G
T
Q
S
K
V
Site 21
T180
L
S
H
T
S
G
G
T
Q
S
K
V
V
P
I
Site 22
S182
H
T
S
G
G
T
Q
S
K
V
V
P
I
A
S
Site 23
S189
S
K
V
V
P
I
A
S
L
T
P
Y
Q
S
K
Site 24
T191
V
V
P
I
A
S
L
T
P
Y
Q
S
K
W
T
Site 25
Y193
P
I
A
S
L
T
P
Y
Q
S
K
W
T
I
C
Site 26
S207
C
A
R
V
T
N
K
S
Q
I
R
T
W
S
N
Site 27
T211
T
N
K
S
Q
I
R
T
W
S
N
S
R
G
E
Site 28
S213
K
S
Q
I
R
T
W
S
N
S
R
G
E
G
K
Site 29
S215
Q
I
R
T
W
S
N
S
R
G
E
G
K
L
F
Site 30
S223
R
G
E
G
K
L
F
S
L
E
L
V
D
E
S
Site 31
T236
E
S
G
E
I
R
A
T
A
F
N
E
Q
V
D
Site 32
Y256
I
E
V
N
K
V
Y
Y
F
S
K
G
T
L
K
Site 33
Y276
F
T
A
V
K
N
D
Y
E
M
T
F
N
N
E
Site 34
T279
V
K
N
D
Y
E
M
T
F
N
N
E
T
S
V
Site 35
T297
E
D
D
H
H
L
P
T
V
Q
F
D
F
T
G
Site 36
T303
P
T
V
Q
F
D
F
T
G
I
D
D
L
E
N
Site 37
S315
L
E
N
K
S
K
D
S
L
V
D
I
I
G
I
Site 38
S336
A
T
K
I
T
V
R
S
N
N
R
E
V
A
K
Site 39
Y347
E
V
A
K
R
N
I
Y
L
M
D
T
S
G
K
Site 40
T359
S
G
K
V
V
T
A
T
L
W
G
E
D
A
D
Site 41
S371
D
A
D
K
F
D
G
S
R
Q
P
V
L
A
I
Site 42
S384
A
I
K
G
A
R
V
S
D
F
G
G
R
S
L
Site 43
S390
V
S
D
F
G
G
R
S
L
S
V
L
S
S
S
Site 44
S392
D
F
G
G
R
S
L
S
V
L
S
S
S
T
I
Site 45
Y409
N
P
D
I
P
E
A
Y
K
L
R
G
W
F
D
Site 46
S426
G
Q
A
L
D
G
V
S
I
S
D
L
K
S
G
Site 47
S432
V
S
I
S
D
L
K
S
G
G
V
G
G
S
N
Site 48
S438
K
S
G
G
V
G
G
S
N
T
N
W
K
T
L
Site 49
T440
G
G
V
G
G
S
N
T
N
W
K
T
L
Y
E
Site 50
T444
G
S
N
T
N
W
K
T
L
Y
E
V
K
S
E
Site 51
Y446
N
T
N
W
K
T
L
Y
E
V
K
S
E
N
L
Site 52
S450
K
T
L
Y
E
V
K
S
E
N
L
G
Q
G
D
Site 53
Y461
G
Q
G
D
K
P
D
Y
F
S
S
V
A
T
V
Site 54
S463
G
D
K
P
D
Y
F
S
S
V
A
T
V
V
Y
Site 55
S464
D
K
P
D
Y
F
S
S
V
A
T
V
V
Y
L
Site 56
T467
D
Y
F
S
S
V
A
T
V
V
Y
L
R
K
E
Site 57
Y470
S
S
V
A
T
V
V
Y
L
R
K
E
N
C
M
Site 58
Y478
L
R
K
E
N
C
M
Y
Q
A
C
P
T
Q
D
Site 59
Y512
T
E
F
P
N
F
K
Y
R
M
I
L
S
V
N
Site 60
T580
R
V
R
V
K
V
E
T
Y
N
D
E
S
R
I
Site 61
Y581
V
R
V
K
V
E
T
Y
N
D
E
S
R
I
K
Site 62
T590
D
E
S
R
I
K
A
T
V
M
D
V
K
P
V
Site 63
Y599
M
D
V
K
P
V
D
Y
R
E
Y
G
R
R
L
Site 64
Y602
K
P
V
D
Y
R
E
Y
G
R
R
L
V
M
S
Site 65
S609
Y
G
R
R
L
V
M
S
I
R
R
S
A
L
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation