PhosphoNET

           
Protein Info 
   
Short Name:  ITPKB
Full Name:  Inositol-trisphosphate 3-kinase B
Alias:  1D-myo-inositol-trisphosphate 3-kinase B; EC 2.7.1.127; Inositol 1,4,5-trisphosphate 3-kinase B; IP3 3-kinase; IP3 3-kinase B; IP3K; IP3K B; IP3KB; IP3K-B; PIG37; Proliferation-inducing protein 37
Type:  Enzyme - Metabolite kinase
Mass (Da):  102376
Number AA:  946
UniProt ID:  P27987
International Prot ID:  IPI00021449
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005516  GO:0008440 PhosphoSite+ KinaseNET
Biological Process:  GO:0007165     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S16NSLVIMNSANEMKSG
Site 2S22NSANEMKSGGGPGPS
Site 3S29SGGGPGPSGSETPPP
Site 4S31GGPGPSGSETPPPPR
Site 5T33PGPSGSETPPPPRRA
Site 6S43PPRRAVLSPGSVFSP
Site 7S46RAVLSPGSVFSPGRG
Site 8S49LSPGSVFSPGRGASF
Site 9S55FSPGRGASFLFPPAE
Site 10S63FLFPPAESLSPEEPR
Site 11S65FPPAESLSPEEPRSP
Site 12S71LSPEEPRSPGGWRSG
Site 13S77RSPGGWRSGRRRLNS
Site 14S84SGRRRLNSSSGSGSG
Site 15S85GRRRLNSSSGSGSGS
Site 16S86RRRLNSSSGSGSGSS
Site 17S88RLNSSSGSGSGSSGS
Site 18S90NSSSGSGSGSSGSSV
Site 19S92SSGSGSGSSGSSVSS
Site 20S93SGSGSGSSGSSVSSP
Site 21S95SGSGSSGSSVSSPSW
Site 22S96GSGSSGSSVSSPSWA
Site 23S98GSSGSSVSSPSWAGR
Site 24S99SSGSSVSSPSWAGRL
Site 25S101GSSVSSPSWAGRLRG
Site 26T118QQVVAAGTLSPPGPE
Site 27S120VVAAGTLSPPGPEEA
Site 28S166SAIQAPRSPRLGRAR
Site 29S174PRLGRARSPSPCPFR
Site 30S176LGRARSPSPCPFRSS
Site 31S182PSPCPFRSSSQPPGR
Site 32S183SPCPFRSSSQPPGRV
Site 33S184PCPFRSSSQPPGRVL
Site 34S197VLVQGARSEERRTKS
Site 35T202ARSEERRTKSWGEQC
Site 36S204SEERRTKSWGEQCPE
Site 37T212WGEQCPETSGTDSGR
Site 38S213GEQCPETSGTDSGRK
Site 39T215QCPETSGTDSGRKGG
Site 40S217PETSGTDSGRKGGPS
Site 41S224SGRKGGPSLCSSQVK
Site 42S227KGGPSLCSSQVKKGM
Site 43S228GGPSLCSSQVKKGMP
Site 44S246GRAAPTGSEAQGPSA
Site 45S264MEKGIPASPRCGSPT
Site 46S269PASPRCGSPTAMEID
Site 47T271SPRCGSPTAMEIDKR
Site 48S280MEIDKRGSPTPGTRS
Site 49T282IDKRGSPTPGTRSCL
Site 50T285RGSPTPGTRSCLAPS
Site 51S287SPTPGTRSCLAPSLG
Site 52T311TEVAARVTSTGPHRP
Site 53S312EVAARVTSTGPHRPQ
Site 54T324RPQDLALTEPSGRAR
Site 55S352RQGQFLGSETSPAPE
Site 56S355QFLGSETSPAPERGG
Site 57Y376PGKMGKGYLPCGMPG
Site 58S384LPCGMPGSGEPEVGK
Site 59T397GKRPEETTVSVQSAE
Site 60S399RPEETTVSVQSAESS
Site 61S402ETTVSVQSAESSDSL
Site 62S405VSVQSAESSDSLSWS
Site 63S406SVQSAESSDSLSWSR
Site 64S408QSAESSDSLSWSRLP
Site 65S410AESSDSLSWSRLPRA
Site 66S412SSDSLSWSRLPRALA
Site 67S420RLPRALASVGPEEAR
Site 68S428VGPEEARSGAPVGGG
Site 69S440GGGRWQLSDRVEGGS
Site 70S447SDRVEGGSPTLGLLG
Site 71S456TLGLLGGSPSAQPGT
Site 72S458GLLGGSPSAQPGTGN
Site 73T463SPSAQPGTGNVEAGI
Site 74S472NVEAGIPSGRMLEPL
Site 75T512NSRVWQGTMEKAGLA
Site 76T524GLAWTRGTGVQSEGT
Site 77S534QSEGTWESQRQDSDA
Site 78S539WESQRQDSDALPSPE
Site 79S544QDSDALPSPELLPQD
Site 80S588ALEETQGSPRGNLPL
Site 81S599NLPLRKLSSSSASST
Site 82S600LPLRKLSSSSASSTG
Site 83S601PLRKLSSSSASSTGF
Site 84S602LRKLSSSSASSTGFS
Site 85S604KLSSSSASSTGFSSS
Site 86S605LSSSSASSTGFSSSY
Site 87T606SSSSASSTGFSSSYE
Site 88S609SASSTGFSSSYEDSE
Site 89S610ASSTGFSSSYEDSEE
Site 90S611SSTGFSSSYEDSEED
Site 91Y612STGFSSSYEDSEEDI
Site 92S615FSSSYEDSEEDISSD
Site 93S620EDSEEDISSDPERTL
Site 94S621DSEEDISSDPERTLD
Site 95T626ISSDPERTLDPNSAF
Site 96S631ERTLDPNSAFLHTLD
Site 97S645DQQKPRVSKSWRKIK
Site 98S647QKPRVSKSWRKIKNM
Site 99Y668VMSFKKKYPWIQLAG
Site 100S679QLAGHAGSFKAAANG
Site 101S695ILKKHCESEQRCLDR
Site 102Y715LRPFVPAYHGDVVKD
Site 103Y751CKMGIRTYLEEELTK
Site 104T757TYLEEELTKARKKPS
Site 105S764TKARKKPSLRKDMYQ
Site 106Y770PSLRKDMYQKMIEVD
Site 107T792EKAQRAVTKPRYMQW
Site 108Y796RAVTKPRYMQWRETI
Site 109T802RYMQWRETISSTATL
Site 110S804MQWRETISSTATLGF
Site 111S805QWRETISSTATLGFR
Site 112T808ETISSTATLGFRIEG
Site 113T822GIKKEDGTVNRDFKK
Site 114T830VNRDFKKTKTREQVT
Site 115T832RDFKKTKTREQVTEA
Site 116T844TEAFREFTKGNHNIL
Site 117Y854NHNILIAYRDRLKAI
Site 118T863DRLKAIRTTLEVSPF
Site 119S868IRTTLEVSPFFKCHE
Site 120T902MIDFGKTTPLPEGQT
Site 121Y925EGNREDGYLSGLNNL
Site 122S927NREDGYLSGLNNLVD
Site 123T937NNLVDILTEMSQDAP
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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