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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMB5
Full Name:
Proteasome subunit beta type-5
Alias:
LMPX; Macropain epsilon chain; MB1; Multicatalytic endopeptidase complex epsilon chain; Proteasome (prosome, macropain) subunit, beta type, 5; Proteasome chain 6; Proteasome epsilon chain; Proteasome subunit beta type 5; Proteasome subunit MB1; Proteasome subunit X; PSB5; X
Type:
Proteasome complex; Protease; EC 3.4.25.1
Mass (Da):
28480
Number AA:
263
UniProt ID:
P28074
International Prot ID:
IPI00479306
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004298
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0051436
GO:0051437
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T62
E
M
L
H
G
T
T
T
L
A
F
K
F
R
H
Site 2
Y99
K
V
I
E
I
N
P
Y
L
L
G
T
M
A
G
Site 3
Y125
L
A
R
Q
C
R
I
Y
E
L
R
N
K
E
R
Site 4
S134
L
R
N
K
E
R
I
S
V
A
A
A
S
K
L
Site 5
S139
R
I
S
V
A
A
A
S
K
L
L
A
N
M
V
Site 6
Y149
L
A
N
M
V
Y
Q
Y
K
G
M
G
L
S
M
Site 7
Y171
D
K
R
G
P
G
L
Y
Y
V
D
S
E
G
N
Site 8
Y172
K
R
G
P
G
L
Y
Y
V
D
S
E
G
N
R
Site 9
S175
P
G
L
Y
Y
V
D
S
E
G
N
R
I
S
G
Site 10
S181
D
S
E
G
N
R
I
S
G
A
T
F
S
V
G
Site 11
T184
G
N
R
I
S
G
A
T
F
S
V
G
S
G
S
Site 12
Y193
S
V
G
S
G
S
V
Y
A
Y
G
V
M
D
R
Site 13
Y195
G
S
G
S
V
Y
A
Y
G
V
M
D
R
G
Y
Site 14
Y202
Y
G
V
M
D
R
G
Y
S
Y
D
L
E
V
E
Site 15
S203
G
V
M
D
R
G
Y
S
Y
D
L
E
V
E
Q
Site 16
Y220
D
L
A
R
R
A
I
Y
Q
A
T
Y
R
D
A
Site 17
Y224
R
A
I
Y
Q
A
T
Y
R
D
A
Y
S
G
G
Site 18
Y228
Q
A
T
Y
R
D
A
Y
S
G
G
A
V
N
L
Site 19
Y236
S
G
G
A
V
N
L
Y
H
V
R
E
D
G
W
Site 20
S247
E
D
G
W
I
R
V
S
S
D
N
V
A
D
L
Site 21
S248
D
G
W
I
R
V
S
S
D
N
V
A
D
L
H
Site 22
Y258
V
A
D
L
H
E
K
Y
S
G
S
T
P
_
_
Site 23
S259
A
D
L
H
E
K
Y
S
G
S
T
P
_
_
_
Site 24
S261
L
H
E
K
Y
S
G
S
T
P
_
_
_
_
_
Site 25
T262
H
E
K
Y
S
G
S
T
P
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation