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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
5-HT(1B)
Full Name:
5-hydroxytryptamine receptor 1B
Alias:
5- HT1B; 5HT1B; 5-HT1B; 5-HT1DB; 5-HT-1D-beta; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine 1B receptor; HTR1B; HTR1D2; HTR1DB; S12; Serotonin 1D beta receptor; Serotonin receptor 1B
Type:
Receptor, GPCR; Membrane protein, integral
Mass (Da):
43550
Number AA:
390
UniProt ID:
P28222
International Prot ID:
IPI00002184
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004993
PhosphoSite+
KinaseNET
Biological Process:
GO:0007187
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
P
P
P
P
A
G
S
E
T
W
V
P
Q
A
Site 2
T18
P
P
P
A
G
S
E
T
W
V
P
Q
A
N
L
Site 3
S26
W
V
P
Q
A
N
L
S
S
A
P
S
Q
N
C
Site 4
S27
V
P
Q
A
N
L
S
S
A
P
S
Q
N
C
S
Site 5
S30
A
N
L
S
S
A
P
S
Q
N
C
S
A
K
D
Site 6
S34
S
A
P
S
Q
N
C
S
A
K
D
Y
I
Y
Q
Site 7
Y38
Q
N
C
S
A
K
D
Y
I
Y
Q
D
S
I
S
Site 8
Y40
C
S
A
K
D
Y
I
Y
Q
D
S
I
S
L
P
Site 9
T60
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
Site 10
T82
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
Site 11
T112
I
S
T
M
Y
T
V
T
G
R
W
T
L
G
Q
Site 12
T152
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
Site 13
S158
I
T
D
A
V
E
Y
S
A
K
R
T
P
K
R
Site 14
T162
V
E
Y
S
A
K
R
T
P
K
R
A
A
V
M
Site 15
S197
A
K
A
E
E
E
V
S
E
C
V
V
N
T
D
Site 16
Y232
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
Site 17
T243
R
S
R
I
L
K
Q
T
P
N
R
T
G
K
R
Site 18
T252
N
R
T
G
K
R
L
T
R
A
Q
L
I
T
D
Site 19
T258
L
T
R
A
Q
L
I
T
D
S
P
G
S
T
S
Site 20
S260
R
A
Q
L
I
T
D
S
P
G
S
T
S
S
V
Site 21
T264
I
T
D
S
P
G
S
T
S
S
V
T
S
I
N
Site 22
S265
T
D
S
P
G
S
T
S
S
V
T
S
I
N
S
Site 23
S266
D
S
P
G
S
T
S
S
V
T
S
I
N
S
R
Site 24
T268
P
G
S
T
S
S
V
T
S
I
N
S
R
V
P
Site 25
S269
G
S
T
S
S
V
T
S
I
N
S
R
V
P
D
Site 26
S272
S
S
V
T
S
I
N
S
R
V
P
D
V
P
S
Site 27
S279
S
R
V
P
D
V
P
S
E
S
G
S
P
V
Y
Site 28
S281
V
P
D
V
P
S
E
S
G
S
P
V
Y
V
N
Site 29
S283
D
V
P
S
E
S
G
S
P
V
Y
V
N
Q
V
Site 30
Y286
S
E
S
G
S
P
V
Y
V
N
Q
V
K
V
R
Site 31
S295
N
Q
V
K
V
R
V
S
D
A
L
L
E
K
K
Site 32
T313
A
A
R
E
R
K
A
T
K
T
L
G
I
I
L
Site 33
T315
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation