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Updated November 2019
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Protein Info
Short Name:
SSFA2
Full Name:
Sperm-specific antigen 2
Alias:
Cleavage signal-1; Cleavage signal-1 protein; CS-1; KIAA1927; Ki-ras-induced actin-interacting protein; KRAP; SPAG13; Sperm specific antigen 2
Type:
Cytoskeletal protein
Mass (Da):
138386
Number AA:
1259
UniProt ID:
P28290
International Prot ID:
IPI00400812
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
D
R
P
L
S
S
S
A
E
A
E
E
Site 2
S8
M
D
R
P
L
S
S
S
A
E
A
E
E
E
L
Site 3
S21
E
L
E
W
Q
V
A
S
R
R
R
K
A
W
A
Site 4
S32
K
A
W
A
K
C
R
S
S
W
Q
A
S
E
T
Site 5
S33
A
W
A
K
C
R
S
S
W
Q
A
S
E
T
E
Site 6
S37
C
R
S
S
W
Q
A
S
E
T
E
D
L
S
T
Site 7
T39
S
S
W
Q
A
S
E
T
E
D
L
S
T
E
A
Site 8
S43
A
S
E
T
E
D
L
S
T
E
A
T
T
Q
D
Site 9
T44
S
E
T
E
D
L
S
T
E
A
T
T
Q
D
E
Site 10
T47
E
D
L
S
T
E
A
T
T
Q
D
E
E
E
D
Site 11
T87
I
W
L
K
D
C
R
T
P
L
G
A
S
L
D
Site 12
S92
C
R
T
P
L
G
A
S
L
D
E
Q
S
S
S
Site 13
S97
G
A
S
L
D
E
Q
S
S
S
T
L
K
G
V
Site 14
S98
A
S
L
D
E
Q
S
S
S
T
L
K
G
V
L
Site 15
S99
S
L
D
E
Q
S
S
S
T
L
K
G
V
L
V
Site 16
S111
V
L
V
R
N
G
G
S
F
E
D
D
L
S
L
Site 17
S117
G
S
F
E
D
D
L
S
L
G
A
E
A
N
H
Site 18
S153
Q
F
H
Q
K
G
R
S
M
N
S
T
G
S
G
Site 19
S156
Q
K
G
R
S
M
N
S
T
G
S
G
K
S
S
Site 20
T157
K
G
R
S
M
N
S
T
G
S
G
K
S
S
G
Site 21
S159
R
S
M
N
S
T
G
S
G
K
S
S
G
T
V
Site 22
S162
N
S
T
G
S
G
K
S
S
G
T
V
S
S
V
Site 23
S163
S
T
G
S
G
K
S
S
G
T
V
S
S
V
S
Site 24
T165
G
S
G
K
S
S
G
T
V
S
S
V
S
E
L
Site 25
S167
G
K
S
S
G
T
V
S
S
V
S
E
L
L
E
Site 26
S168
K
S
S
G
T
V
S
S
V
S
E
L
L
E
L
Site 27
S170
S
G
T
V
S
S
V
S
E
L
L
E
L
Y
E
Site 28
Y176
V
S
E
L
L
E
L
Y
E
E
D
P
E
E
I
Site 29
Y185
E
D
P
E
E
I
L
Y
N
L
G
F
G
R
D
Site 30
S198
R
D
E
P
D
I
A
S
K
I
P
S
R
F
F
Site 31
S202
D
I
A
S
K
I
P
S
R
F
F
N
S
S
S
Site 32
S208
P
S
R
F
F
N
S
S
S
F
A
K
G
I
D
Site 33
S209
S
R
F
F
N
S
S
S
F
A
K
G
I
D
I
Site 34
Y234
M
E
V
E
N
P
N
Y
A
L
T
S
R
F
R
Site 35
T237
E
N
P
N
Y
A
L
T
S
R
F
R
Q
I
E
Site 36
Y257
A
N
A
F
S
S
L
Y
S
Q
V
S
G
T
P
Site 37
S258
N
A
F
S
S
L
Y
S
Q
V
S
G
T
P
L
Site 38
S261
S
S
L
Y
S
Q
V
S
G
T
P
L
Q
R
I
Site 39
T263
L
Y
S
Q
V
S
G
T
P
L
Q
R
I
G
S
Site 40
S270
T
P
L
Q
R
I
G
S
M
S
S
V
T
S
N
Site 41
S272
L
Q
R
I
G
S
M
S
S
V
T
S
N
K
E
Site 42
S273
Q
R
I
G
S
M
S
S
V
T
S
N
K
E
T
Site 43
S276
G
S
M
S
S
V
T
S
N
K
E
T
D
P
P
Site 44
T280
S
V
T
S
N
K
E
T
D
P
P
P
P
L
T
Site 45
T287
T
D
P
P
P
P
L
T
R
S
N
T
A
N
R
Site 46
S289
P
P
P
P
L
T
R
S
N
T
A
N
R
L
M
Site 47
T291
P
P
L
T
R
S
N
T
A
N
R
L
M
K
T
Site 48
T298
T
A
N
R
L
M
K
T
L
S
K
L
N
L
C
Site 49
S300
N
R
L
M
K
T
L
S
K
L
N
L
C
V
D
Site 50
T309
L
N
L
C
V
D
K
T
E
K
G
E
S
S
S
Site 51
S314
D
K
T
E
K
G
E
S
S
S
P
S
P
S
A
Site 52
S315
K
T
E
K
G
E
S
S
S
P
S
P
S
A
E
Site 53
S316
T
E
K
G
E
S
S
S
P
S
P
S
A
E
K
Site 54
S318
K
G
E
S
S
S
P
S
P
S
A
E
K
G
K
Site 55
S320
E
S
S
S
P
S
P
S
A
E
K
G
K
I
L
Site 56
S330
K
G
K
I
L
N
V
S
V
I
E
E
S
G
N
Site 57
S343
G
N
K
N
D
Q
K
S
Q
K
I
M
K
K
K
Site 58
S352
K
I
M
K
K
K
E
S
S
S
M
L
A
T
V
Site 59
S354
M
K
K
K
E
S
S
S
M
L
A
T
V
K
E
Site 60
T358
E
S
S
S
M
L
A
T
V
K
E
E
V
S
G
Site 61
S366
V
K
E
E
V
S
G
S
S
A
A
V
T
E
N
Site 62
S367
K
E
E
V
S
G
S
S
A
A
V
T
E
N
A
Site 63
T371
S
G
S
S
A
A
V
T
E
N
A
D
S
D
R
Site 64
S376
A
V
T
E
N
A
D
S
D
R
I
S
D
E
A
Site 65
S380
N
A
D
S
D
R
I
S
D
E
A
N
S
N
F
Site 66
S396
Q
G
T
E
N
E
Q
S
K
E
T
Q
S
H
E
Site 67
S401
E
Q
S
K
E
T
Q
S
H
E
S
K
L
G
E
Site 68
S410
E
S
K
L
G
E
E
S
G
I
V
E
S
K
L
Site 69
S415
E
E
S
G
I
V
E
S
K
L
D
S
D
F
N
Site 70
S419
I
V
E
S
K
L
D
S
D
F
N
I
S
S
H
Site 71
S424
L
D
S
D
F
N
I
S
S
H
S
E
L
E
N
Site 72
S425
D
S
D
F
N
I
S
S
H
S
E
L
E
N
S
Site 73
S427
D
F
N
I
S
S
H
S
E
L
E
N
S
S
E
Site 74
S432
S
H
S
E
L
E
N
S
S
E
L
K
S
V
H
Site 75
S433
H
S
E
L
E
N
S
S
E
L
K
S
V
H
I
Site 76
S437
E
N
S
S
E
L
K
S
V
H
I
S
T
P
E
Site 77
S441
E
L
K
S
V
H
I
S
T
P
E
K
E
P
C
Site 78
T442
L
K
S
V
H
I
S
T
P
E
K
E
P
C
A
Site 79
T452
K
E
P
C
A
P
L
T
I
P
S
I
R
N
I
Site 80
T461
P
S
I
R
N
I
M
T
Q
Q
K
D
S
F
E
Site 81
S466
I
M
T
Q
Q
K
D
S
F
E
M
E
E
V
Q
Site 82
S474
F
E
M
E
E
V
Q
S
T
E
G
E
A
P
H
Site 83
T475
E
M
E
E
V
Q
S
T
E
G
E
A
P
H
V
Site 84
T485
E
A
P
H
V
P
A
T
Y
Q
L
G
L
T
K
Site 85
T491
A
T
Y
Q
L
G
L
T
K
S
K
R
D
H
L
Site 86
S493
Y
Q
L
G
L
T
K
S
K
R
D
H
L
L
R
Site 87
T501
K
R
D
H
L
L
R
T
A
S
Q
H
S
D
S
Site 88
S503
D
H
L
L
R
T
A
S
Q
H
S
D
S
S
G
Site 89
S506
L
R
T
A
S
Q
H
S
D
S
S
G
F
A
E
Site 90
S508
T
A
S
Q
H
S
D
S
S
G
F
A
E
D
S
Site 91
S509
A
S
Q
H
S
D
S
S
G
F
A
E
D
S
T
Site 92
S515
S
S
G
F
A
E
D
S
T
D
C
L
S
L
N
Site 93
T516
S
G
F
A
E
D
S
T
D
C
L
S
L
N
H
Site 94
S520
E
D
S
T
D
C
L
S
L
N
H
L
Q
V
Q
Site 95
S529
N
H
L
Q
V
Q
E
S
L
Q
A
M
G
S
S
Site 96
S535
E
S
L
Q
A
M
G
S
S
A
D
S
C
D
S
Site 97
S536
S
L
Q
A
M
G
S
S
A
D
S
C
D
S
E
Site 98
S539
A
M
G
S
S
A
D
S
C
D
S
E
T
T
V
Site 99
S542
S
S
A
D
S
C
D
S
E
T
T
V
T
S
L
Site 100
T544
A
D
S
C
D
S
E
T
T
V
T
S
L
G
E
Site 101
T545
D
S
C
D
S
E
T
T
V
T
S
L
G
E
D
Site 102
S548
D
S
E
T
T
V
T
S
L
G
E
D
L
A
T
Site 103
T555
S
L
G
E
D
L
A
T
P
T
A
Q
D
Q
P
Site 104
Y563
P
T
A
Q
D
Q
P
Y
F
N
E
S
E
E
E
Site 105
S567
D
Q
P
Y
F
N
E
S
E
E
E
S
L
V
P
Site 106
S571
F
N
E
S
E
E
E
S
L
V
P
L
Q
K
G
Site 107
S591
A
V
A
D
K
R
K
S
G
S
Q
D
F
P
Q
Site 108
S593
A
D
K
R
K
S
G
S
Q
D
F
P
Q
C
N
Site 109
T607
N
T
I
E
N
T
G
T
K
Q
S
T
C
S
P
Site 110
S610
E
N
T
G
T
K
Q
S
T
C
S
P
G
D
H
Site 111
T611
N
T
G
T
K
Q
S
T
C
S
P
G
D
H
I
Site 112
S613
G
T
K
Q
S
T
C
S
P
G
D
H
I
I
E
Site 113
T633
E
D
L
F
P
A
E
T
V
E
L
L
R
E
A
Site 114
S641
V
E
L
L
R
E
A
S
A
E
S
D
V
G
K
Site 115
S644
L
R
E
A
S
A
E
S
D
V
G
K
S
S
E
Site 116
S649
A
E
S
D
V
G
K
S
S
E
S
E
F
T
Q
Site 117
S650
E
S
D
V
G
K
S
S
E
S
E
F
T
Q
Y
Site 118
T655
K
S
S
E
S
E
F
T
Q
Y
T
T
H
H
I
Site 119
Y657
S
E
S
E
F
T
Q
Y
T
T
H
H
I
L
K
Site 120
S665
T
T
H
H
I
L
K
S
L
A
S
I
E
A
K
Site 121
S668
H
I
L
K
S
L
A
S
I
E
A
K
C
S
D
Site 122
S674
A
S
I
E
A
K
C
S
D
M
S
S
E
N
T
Site 123
S677
E
A
K
C
S
D
M
S
S
E
N
T
T
G
P
Site 124
S678
A
K
C
S
D
M
S
S
E
N
T
T
G
P
P
Site 125
T681
S
D
M
S
S
E
N
T
T
G
P
P
S
S
M
Site 126
T682
D
M
S
S
E
N
T
T
G
P
P
S
S
M
D
Site 127
S686
E
N
T
T
G
P
P
S
S
M
D
R
V
N
T
Site 128
S687
N
T
T
G
P
P
S
S
M
D
R
V
N
T
A
Site 129
T693
S
S
M
D
R
V
N
T
A
L
Q
R
A
Q
M
Site 130
S704
R
A
Q
M
K
V
C
S
L
S
N
Q
R
M
G
Site 131
S706
Q
M
K
V
C
S
L
S
N
Q
R
M
G
R
S
Site 132
S713
S
N
Q
R
M
G
R
S
L
L
K
S
K
D
L
Site 133
S717
M
G
R
S
L
L
K
S
K
D
L
L
K
Q
R
Site 134
Y725
K
D
L
L
K
Q
R
Y
L
F
A
K
A
G
Y
Site 135
Y732
Y
L
F
A
K
A
G
Y
P
L
R
R
S
Q
S
Site 136
S737
A
G
Y
P
L
R
R
S
Q
S
L
P
T
T
L
Site 137
S739
Y
P
L
R
R
S
Q
S
L
P
T
T
L
L
S
Site 138
T742
R
R
S
Q
S
L
P
T
T
L
L
S
P
V
R
Site 139
T743
R
S
Q
S
L
P
T
T
L
L
S
P
V
R
V
Site 140
S746
S
L
P
T
T
L
L
S
P
V
R
V
V
S
S
Site 141
S752
L
S
P
V
R
V
V
S
S
V
N
V
R
L
S
Site 142
S759
S
S
V
N
V
R
L
S
P
G
K
E
T
R
C
Site 143
T764
R
L
S
P
G
K
E
T
R
C
S
P
P
S
F
Site 144
S767
P
G
K
E
T
R
C
S
P
P
S
F
T
Y
K
Site 145
S770
E
T
R
C
S
P
P
S
F
T
Y
K
Y
T
P
Site 146
T772
R
C
S
P
P
S
F
T
Y
K
Y
T
P
E
E
Site 147
Y773
C
S
P
P
S
F
T
Y
K
Y
T
P
E
E
E
Site 148
Y775
P
P
S
F
T
Y
K
Y
T
P
E
E
E
Q
E
Site 149
T776
P
S
F
T
Y
K
Y
T
P
E
E
E
Q
E
L
Site 150
S794
V
M
E
H
D
G
Q
S
L
V
K
S
T
I
F
Site 151
S798
D
G
Q
S
L
V
K
S
T
I
F
I
S
P
S
Site 152
S803
V
K
S
T
I
F
I
S
P
S
S
V
K
K
E
Site 153
S805
S
T
I
F
I
S
P
S
S
V
K
K
E
E
A
Site 154
S806
T
I
F
I
S
P
S
S
V
K
K
E
E
A
P
Site 155
S815
K
K
E
E
A
P
Q
S
E
A
P
R
V
E
E
Site 156
T828
E
E
C
H
H
G
R
T
P
T
C
S
R
L
A
Site 157
T830
C
H
H
G
R
T
P
T
C
S
R
L
A
P
P
Site 158
S832
H
G
R
T
P
T
C
S
R
L
A
P
P
P
M
Site 159
S840
R
L
A
P
P
P
M
S
Q
S
T
C
S
L
H
Site 160
S842
A
P
P
P
M
S
Q
S
T
C
S
L
H
S
I
Site 161
T843
P
P
P
M
S
Q
S
T
C
S
L
H
S
I
H
Site 162
S845
P
M
S
Q
S
T
C
S
L
H
S
I
H
S
E
Site 163
S848
Q
S
T
C
S
L
H
S
I
H
S
E
W
Q
E
Site 164
S851
C
S
L
H
S
I
H
S
E
W
Q
E
R
P
L
Site 165
T862
E
R
P
L
C
E
H
T
R
T
L
S
T
H
S
Site 166
T864
P
L
C
E
H
T
R
T
L
S
T
H
S
V
P
Site 167
S866
C
E
H
T
R
T
L
S
T
H
S
V
P
N
I
Site 168
T867
E
H
T
R
T
L
S
T
H
S
V
P
N
I
S
Site 169
S869
T
R
T
L
S
T
H
S
V
P
N
I
S
G
A
Site 170
T895
P
Y
S
H
R
H
A
T
Y
P
Y
R
V
C
S
Site 171
Y896
Y
S
H
R
H
A
T
Y
P
Y
R
V
C
S
V
Site 172
Y898
H
R
H
A
T
Y
P
Y
R
V
C
S
V
N
P
Site 173
S902
T
Y
P
Y
R
V
C
S
V
N
P
P
S
A
I
Site 174
S923
V
L
H
D
I
R
N
S
L
Q
N
L
S
Q
Y
Site 175
S928
R
N
S
L
Q
N
L
S
Q
Y
P
M
M
R
G
Site 176
Y930
S
L
Q
N
L
S
Q
Y
P
M
M
R
G
P
D
Site 177
S944
D
P
A
A
A
P
Y
S
T
Q
K
S
S
V
L
Site 178
T945
P
A
A
A
P
Y
S
T
Q
K
S
S
V
L
P
Site 179
S948
A
P
Y
S
T
Q
K
S
S
V
L
P
L
Y
E
Site 180
S949
P
Y
S
T
Q
K
S
S
V
L
P
L
Y
E
N
Site 181
Y954
K
S
S
V
L
P
L
Y
E
N
T
F
Q
E
L
Site 182
S967
E
L
Q
V
M
R
R
S
L
N
L
F
R
T
Q
Site 183
T973
R
S
L
N
L
F
R
T
Q
M
M
D
L
E
L
Site 184
S1010
Q
L
Q
G
L
R
N
S
V
R
M
E
L
Q
D
Site 185
S1040
L
R
A
V
R
M
P
S
P
F
R
S
S
A
L
Site 186
S1044
R
M
P
S
P
F
R
S
S
A
L
M
G
M
C
Site 187
S1045
M
P
S
P
F
R
S
S
A
L
M
G
M
C
G
Site 188
S1053
A
L
M
G
M
C
G
S
R
S
A
D
N
L
S
Site 189
S1055
M
G
M
C
G
S
R
S
A
D
N
L
S
C
P
Site 190
S1060
S
R
S
A
D
N
L
S
C
P
S
P
L
N
V
Site 191
S1063
A
D
N
L
S
C
P
S
P
L
N
V
M
E
P
Site 192
S1079
T
E
L
M
Q
E
Q
S
Y
L
K
S
E
L
G
Site 193
Y1080
E
L
M
Q
E
Q
S
Y
L
K
S
E
L
G
L
Site 194
S1083
Q
E
Q
S
Y
L
K
S
E
L
G
L
G
L
G
Site 195
S1102
E
I
P
P
G
E
S
S
E
S
V
F
S
Q
A
Site 196
S1104
P
P
G
E
S
S
E
S
V
F
S
Q
A
T
S
Site 197
S1107
E
S
S
E
S
V
F
S
Q
A
T
S
E
S
S
Site 198
T1110
E
S
V
F
S
Q
A
T
S
E
S
S
S
V
C
Site 199
S1111
S
V
F
S
Q
A
T
S
E
S
S
S
V
C
S
Site 200
S1113
F
S
Q
A
T
S
E
S
S
S
V
C
S
G
P
Site 201
S1114
S
Q
A
T
S
E
S
S
S
V
C
S
G
P
S
Site 202
S1115
Q
A
T
S
E
S
S
S
V
C
S
G
P
S
H
Site 203
S1118
S
E
S
S
S
V
C
S
G
P
S
H
A
N
R
Site 204
S1121
S
S
V
C
S
G
P
S
H
A
N
R
R
T
G
Site 205
T1127
P
S
H
A
N
R
R
T
G
V
P
S
T
A
S
Site 206
S1131
N
R
R
T
G
V
P
S
T
A
S
V
G
K
S
Site 207
T1132
R
R
T
G
V
P
S
T
A
S
V
G
K
S
K
Site 208
S1134
T
G
V
P
S
T
A
S
V
G
K
S
K
T
P
Site 209
S1138
S
T
A
S
V
G
K
S
K
T
P
L
V
A
R
Site 210
T1140
A
S
V
G
K
S
K
T
P
L
V
A
R
K
K
Site 211
S1152
R
K
K
V
F
R
A
S
V
A
L
T
P
T
A
Site 212
T1156
F
R
A
S
V
A
L
T
P
T
A
P
S
R
T
Site 213
T1158
A
S
V
A
L
T
P
T
A
P
S
R
T
G
S
Site 214
S1161
A
L
T
P
T
A
P
S
R
T
G
S
V
Q
T
Site 215
T1163
T
P
T
A
P
S
R
T
G
S
V
Q
T
P
P
Site 216
S1165
T
A
P
S
R
T
G
S
V
Q
T
P
P
D
L
Site 217
T1168
S
R
T
G
S
V
Q
T
P
P
D
L
E
S
S
Site 218
S1174
Q
T
P
P
D
L
E
S
S
E
E
V
D
A
A
Site 219
S1175
T
P
P
D
L
E
S
S
E
E
V
D
A
A
E
Site 220
S1192
P
E
V
V
G
P
K
S
E
V
E
E
G
H
G
Site 221
S1203
E
G
H
G
K
L
P
S
M
P
A
A
E
E
M
Site 222
S1229
V
I
R
E
I
K
E
S
I
V
G
E
I
R
R
Site 223
S1247
S
G
L
L
A
A
V
S
S
S
K
A
S
N
S
Site 224
S1248
G
L
L
A
A
V
S
S
S
K
A
S
N
S
K
Site 225
S1249
L
L
A
A
V
S
S
S
K
A
S
N
S
K
Q
Site 226
S1252
A
V
S
S
S
K
A
S
N
S
K
Q
D
Y
H
Site 227
S1254
S
S
S
K
A
S
N
S
K
Q
D
Y
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation