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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LOX
Full Name:
Protein-lysine 6-oxidase
Alias:
LYOX; lysyl oxidase; protein-lysine 6-oxidase
Type:
EC 1.4.3.13; Oxidoreductase
Mass (Da):
46944
Number AA:
417
UniProt ID:
P28300
International Prot ID:
IPI00002802
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005507
GO:0004720
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S56
E
N
N
G
Q
V
F
S
L
L
S
L
G
S
Q
Site 2
S59
G
Q
V
F
S
L
L
S
L
G
S
Q
Y
Q
P
Site 3
S62
F
S
L
L
S
L
G
S
Q
Y
Q
P
Q
R
R
Site 4
T89
A
S
A
Q
Q
P
R
T
P
I
L
L
I
R
D
Site 5
T106
T
A
A
A
R
T
R
T
A
G
S
S
G
V
T
Site 6
S110
R
T
R
T
A
G
S
S
G
V
T
A
G
R
P
Site 7
T120
T
A
G
R
P
R
P
T
A
R
H
W
F
Q
A
Site 8
S140
R
A
R
E
A
G
A
S
R
A
E
N
Q
T
A
Site 9
T146
A
S
R
A
E
N
Q
T
A
P
G
E
V
P
A
Site 10
S155
P
G
E
V
P
A
L
S
N
L
R
P
P
S
R
Site 11
S161
L
S
N
L
R
P
P
S
R
V
D
G
M
V
G
Site 12
Y172
G
M
V
G
D
D
P
Y
N
P
Y
K
Y
S
D
Site 13
Y177
D
P
Y
N
P
Y
K
Y
S
D
D
N
P
Y
Y
Site 14
Y183
K
Y
S
D
D
N
P
Y
Y
N
Y
Y
D
T
Y
Site 15
Y184
Y
S
D
D
N
P
Y
Y
N
Y
Y
D
T
Y
E
Site 16
Y186
D
D
N
P
Y
Y
N
Y
Y
D
T
Y
E
R
P
Site 17
Y187
D
N
P
Y
Y
N
Y
Y
D
T
Y
E
R
P
R
Site 18
T189
P
Y
Y
N
Y
Y
D
T
Y
E
R
P
R
P
G
Site 19
Y190
Y
Y
N
Y
Y
D
T
Y
E
R
P
R
P
G
G
Site 20
Y199
R
P
R
P
G
G
R
Y
R
P
G
Y
G
T
G
Site 21
Y203
G
G
R
Y
R
P
G
Y
G
T
G
Y
F
Q
Y
Site 22
T205
R
Y
R
P
G
Y
G
T
G
Y
F
Q
Y
G
L
Site 23
Y207
R
P
G
Y
G
T
G
Y
F
Q
Y
G
L
P
D
Site 24
Y220
P
D
L
V
A
D
P
Y
Y
I
Q
A
S
T
Y
Site 25
Y227
Y
Y
I
Q
A
S
T
Y
V
Q
K
M
S
M
Y
Site 26
Y257
Y
R
A
D
V
R
D
Y
D
H
R
V
L
L
R
Site 27
S280
G
T
S
D
F
L
P
S
R
P
R
Y
S
W
E
Site 28
Y304
S
M
D
E
F
S
H
Y
D
L
L
D
A
N
T
Site 29
T311
Y
D
L
L
D
A
N
T
Q
R
R
V
A
E
G
Site 30
S322
V
A
E
G
H
K
A
S
F
C
L
E
D
T
S
Site 31
Y332
L
E
D
T
S
C
D
Y
G
Y
H
R
R
F
A
Site 32
Y334
D
T
S
C
D
Y
G
Y
H
R
R
F
A
C
T
Site 33
T344
R
F
A
C
T
A
H
T
Q
G
L
S
P
G
C
Site 34
S348
T
A
H
T
Q
G
L
S
P
G
C
Y
D
T
Y
Site 35
Y352
Q
G
L
S
P
G
C
Y
D
T
Y
G
A
D
I
Site 36
T354
L
S
P
G
C
Y
D
T
Y
G
A
D
I
D
C
Site 37
Y355
S
P
G
C
Y
D
T
Y
G
A
D
I
D
C
Q
Site 38
S383
L
K
V
S
V
N
P
S
Y
L
V
P
E
S
D
Site 39
Y384
K
V
S
V
N
P
S
Y
L
V
P
E
S
D
Y
Site 40
S389
P
S
Y
L
V
P
E
S
D
Y
T
N
N
V
V
Site 41
Y391
Y
L
V
P
E
S
D
Y
T
N
N
V
V
R
C
Site 42
T392
L
V
P
E
S
D
Y
T
N
N
V
V
R
C
D
Site 43
Y402
V
V
R
C
D
I
R
Y
T
G
H
H
A
Y
A
Site 44
T403
V
R
C
D
I
R
Y
T
G
H
H
A
Y
A
S
Site 45
Y408
R
Y
T
G
H
H
A
Y
A
S
G
C
T
I
S
Site 46
Y417
S
G
C
T
I
S
P
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation