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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLD1
Full Name:
DNA polymerase delta catalytic subunit
Alias:
DNA polymerase subunit delta p125
Type:
Nucleotide Metabolism - pyrimidine; DNA repair; Transferase; Nucleotide Metabolism - purine; Hydrolase; EC 2.7.7.7; DNA replication
Mass (Da):
123631
Number AA:
1107
UniProt ID:
P28340
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003887
GO:0003682
PhosphoSite+
KinaseNET
Biological Process:
GO:0000731
GO:0000084
GO:0006297
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
D
D
D
A
P
R
P
S
Q
F
E
E
D
L
A
Site 2
S60
Q
E
E
E
E
L
Q
S
V
L
E
G
V
A
D
Site 3
S73
A
D
G
Q
V
P
P
S
A
I
D
P
R
W
L
Site 4
T83
D
P
R
W
L
R
P
T
P
P
A
L
D
P
Q
Site 5
T91
P
P
A
L
D
P
Q
T
E
P
L
I
F
Q
Q
Site 6
Y104
Q
Q
L
E
I
D
H
Y
V
G
P
A
Q
P
V
Site 7
S118
V
P
G
G
P
P
P
S
R
G
S
V
P
V
L
Site 8
S121
G
P
P
P
S
R
G
S
V
P
V
L
R
A
F
Site 9
Y147
H
I
H
G
F
A
P
Y
F
Y
T
P
A
P
P
Site 10
Y149
H
G
F
A
P
Y
F
Y
T
P
A
P
P
G
F
Site 11
S173
R
E
L
N
L
A
I
S
R
D
S
R
G
G
R
Site 12
S176
N
L
A
I
S
R
D
S
R
G
G
R
E
L
T
Site 13
Y201
S
R
E
S
M
F
G
Y
H
G
H
G
P
S
P
Site 14
S207
G
Y
H
G
H
G
P
S
P
F
L
R
I
T
V
Site 15
Y244
G
T
P
S
F
A
P
Y
E
A
N
V
D
F
E
Site 16
Y273
L
E
L
P
A
G
K
Y
A
L
R
L
K
E
K
Site 17
S297
V
L
W
S
D
V
V
S
H
P
P
E
G
P
W
Site 18
S314
I
A
P
L
R
V
L
S
F
D
I
E
C
A
G
Site 19
Y371
L
G
A
K
V
Q
S
Y
E
K
E
E
D
L
L
Site 20
Y405
I
Q
N
F
D
L
P
Y
L
I
S
R
A
Q
T
Site 21
T412
Y
L
I
S
R
A
Q
T
L
K
V
Q
T
F
P
Site 22
S429
G
R
V
A
G
L
C
S
N
I
R
D
S
S
F
Site 23
S434
L
C
S
N
I
R
D
S
S
F
Q
S
K
Q
T
Site 24
S435
C
S
N
I
R
D
S
S
F
Q
S
K
Q
T
G
Site 25
S438
I
R
D
S
S
F
Q
S
K
Q
T
G
R
R
D
Site 26
T441
S
S
F
Q
S
K
Q
T
G
R
R
D
T
K
V
Site 27
T446
K
Q
T
G
R
R
D
T
K
V
V
S
M
V
G
Site 28
S450
R
R
D
T
K
V
V
S
M
V
G
R
V
Q
M
Site 29
Y467
L
Q
V
L
L
R
E
Y
K
L
R
S
Y
T
L
Site 30
Y472
R
E
Y
K
L
R
S
Y
T
L
N
A
V
S
F
Site 31
T473
E
Y
K
L
R
S
Y
T
L
N
A
V
S
F
H
Site 32
S478
S
Y
T
L
N
A
V
S
F
H
F
L
G
E
Q
Site 33
T504
L
Q
N
G
N
D
Q
T
R
R
R
L
A
V
Y
Site 34
Y511
T
R
R
R
L
A
V
Y
C
L
K
D
A
Y
L
Site 35
S544
R
V
T
G
V
P
L
S
Y
L
L
S
R
G
Q
Site 36
S557
G
Q
Q
V
K
V
V
S
Q
L
L
R
Q
A
M
Site 37
S575
L
L
M
P
V
V
K
S
E
G
G
E
D
Y
T
Site 38
Y581
K
S
E
G
G
E
D
Y
T
G
A
T
V
I
E
Site 39
T582
S
E
G
G
E
D
Y
T
G
A
T
V
I
E
P
Site 40
T585
G
E
D
Y
T
G
A
T
V
I
E
P
L
K
G
Site 41
T626
T
T
L
L
R
P
G
T
A
Q
K
L
G
L
T
Site 42
T640
T
E
D
Q
F
I
R
T
P
T
G
D
E
F
V
Site 43
T642
D
Q
F
I
R
T
P
T
G
D
E
F
V
K
T
Site 44
T649
T
G
D
E
F
V
K
T
S
V
R
K
G
L
L
Site 45
S650
G
D
E
F
V
K
T
S
V
R
K
G
L
L
P
Site 46
S665
Q
I
L
E
N
L
L
S
A
R
K
R
A
K
A
Site 47
S719
P
C
L
E
I
S
Q
S
V
T
G
F
G
R
Q
Site 48
Y739
K
Q
L
V
E
S
K
Y
T
V
E
N
G
Y
S
Site 49
T740
Q
L
V
E
S
K
Y
T
V
E
N
G
Y
S
T
Site 50
S746
Y
T
V
E
N
G
Y
S
T
S
A
K
V
V
Y
Site 51
S783
R
E
A
A
D
W
V
S
G
H
F
P
S
P
I
Site 52
S788
W
V
S
G
H
F
P
S
P
I
R
L
E
F
E
Site 53
Y801
F
E
K
V
Y
F
P
Y
L
L
I
S
K
K
R
Site 54
Y809
L
L
I
S
K
K
R
Y
A
G
L
L
F
S
S
Site 55
S815
R
Y
A
G
L
L
F
S
S
R
P
D
A
H
D
Site 56
T845
P
L
V
A
N
L
V
T
A
S
L
R
R
L
L
Site 57
S847
V
A
N
L
V
T
A
S
L
R
R
L
L
I
D
Site 58
S892
K
E
L
T
R
A
A
S
D
Y
A
G
K
Q
A
Site 59
Y894
L
T
R
A
A
S
D
Y
A
G
K
Q
A
H
V
Site 60
S914
M
R
K
R
D
P
G
S
A
P
S
L
G
D
R
Site 61
S917
R
D
P
G
S
A
P
S
L
G
D
R
V
P
Y
Site 62
Y956
S
L
P
I
D
T
Q
Y
Y
L
E
Q
Q
L
A
Site 63
Y957
L
P
I
D
T
Q
Y
Y
L
E
Q
Q
L
A
K
Site 64
T993
G
D
H
T
R
C
K
T
V
L
T
G
K
V
G
Site 65
S1034
E
F
C
Q
P
R
E
S
E
L
Y
Q
K
E
V
Site 66
Y1037
Q
P
R
E
S
E
L
Y
Q
K
E
V
S
H
L
Site 67
Y1080
S
R
D
C
P
I
F
Y
M
R
K
K
V
R
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation