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Updated November 2019
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Protein Info
Short Name:
ERCC5
Full Name:
DNA repair protein complementing XP-G cells
Alias:
Cockayne syndrome; DNA excision repair protein ERCC-5; ERCM2; Excision repair cross-complementing rodent repair deficiency, complementation group 5; Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome)); Xeroderma pigmentosum group G complementing protein; Xeroderma pigmentosum group G-complementing protein; XPGC
Type:
DNA repair protein
Mass (Da):
133108
Number AA:
1186
UniProt ID:
P28715
International Prot ID:
IPI00477535
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0000405
GO:0003690
GO:0004520
PhosphoSite+
KinaseNET
Biological Process:
GO:0009650
GO:0043066
GO:0000718
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
W
K
L
L
E
C
S
G
R
Q
V
S
P
E
Site 2
S18
E
C
S
G
R
Q
V
S
P
E
A
L
E
G
K
Site 3
T87
A
P
L
L
K
K
Q
T
L
V
K
R
R
Q
R
Site 4
S99
R
Q
R
K
D
L
A
S
S
D
S
R
K
T
T
Site 5
S100
Q
R
K
D
L
A
S
S
D
S
R
K
T
T
E
Site 6
S102
K
D
L
A
S
S
D
S
R
K
T
T
E
K
L
Site 7
T105
A
S
S
D
S
R
K
T
T
E
K
L
L
K
T
Site 8
T106
S
S
D
S
R
K
T
T
E
K
L
L
K
T
F
Site 9
T112
T
T
E
K
L
L
K
T
F
L
K
R
Q
A
I
Site 10
T121
L
K
R
Q
A
I
K
T
A
F
R
S
K
R
D
Site 11
S125
A
I
K
T
A
F
R
S
K
R
D
E
A
L
P
Site 12
S133
K
R
D
E
A
L
P
S
L
T
Q
V
R
R
E
Site 13
T135
D
E
A
L
P
S
L
T
Q
V
R
R
E
N
D
Site 14
Y144
V
R
R
E
N
D
L
Y
V
L
P
P
L
Q
E
Site 15
S156
L
Q
E
E
E
K
H
S
S
E
E
E
D
E
K
Site 16
S157
Q
E
E
E
K
H
S
S
E
E
E
D
E
K
E
Site 17
S190
P
Q
A
I
D
I
E
S
E
D
F
S
S
L
P
Site 18
S194
D
I
E
S
E
D
F
S
S
L
P
P
E
V
K
Site 19
S195
I
E
S
E
D
F
S
S
L
P
P
E
V
K
H
Site 20
T212
L
T
D
M
K
E
F
T
K
R
R
R
T
L
F
Site 21
T217
E
F
T
K
R
R
R
T
L
F
E
A
M
P
E
Site 22
S226
F
E
A
M
P
E
E
S
D
D
F
S
Q
Y
Q
Site 23
S230
P
E
E
S
D
D
F
S
Q
Y
Q
L
K
G
L
Site 24
Y232
E
S
D
D
F
S
Q
Y
Q
L
K
G
L
L
K
Site 25
Y242
K
G
L
L
K
K
N
Y
L
N
Q
H
I
E
H
Site 26
Y266
S
G
H
I
R
R
Q
Y
E
D
E
G
G
F
L
Site 27
S278
G
F
L
K
E
V
E
S
R
R
V
V
S
E
D
Site 28
S283
V
E
S
R
R
V
V
S
E
D
T
S
H
Y
I
Site 29
T286
R
R
V
V
S
E
D
T
S
H
Y
I
L
I
K
Site 30
S287
R
V
V
S
E
D
T
S
H
Y
I
L
I
K
G
Site 31
Y289
V
S
E
D
T
S
H
Y
I
L
I
K
G
I
Q
Site 32
T299
I
K
G
I
Q
A
K
T
V
A
E
V
D
S
E
Site 33
S305
K
T
V
A
E
V
D
S
E
S
L
P
S
S
S
Site 34
S307
V
A
E
V
D
S
E
S
L
P
S
S
S
K
M
Site 35
S310
V
D
S
E
S
L
P
S
S
S
K
M
H
G
M
Site 36
S311
D
S
E
S
L
P
S
S
S
K
M
H
G
M
S
Site 37
S312
S
E
S
L
P
S
S
S
K
M
H
G
M
S
F
Site 38
S318
S
S
K
M
H
G
M
S
F
D
V
K
S
S
P
Site 39
S323
G
M
S
F
D
V
K
S
S
P
C
E
K
L
K
Site 40
S324
M
S
F
D
V
K
S
S
P
C
E
K
L
K
T
Site 41
T331
S
P
C
E
K
L
K
T
E
K
E
P
D
A
T
Site 42
T338
T
E
K
E
P
D
A
T
P
P
S
P
R
T
L
Site 43
S341
E
P
D
A
T
P
P
S
P
R
T
L
L
A
M
Site 44
S355
M
Q
A
A
L
L
G
S
S
S
E
E
E
L
E
Site 45
S356
Q
A
A
L
L
G
S
S
S
E
E
E
L
E
S
Site 46
S357
A
A
L
L
G
S
S
S
E
E
E
L
E
S
E
Site 47
S363
S
S
E
E
E
L
E
S
E
N
R
R
Q
A
R
Site 48
S382
P
A
A
V
D
E
G
S
I
S
P
R
T
L
S
Site 49
S384
A
V
D
E
G
S
I
S
P
R
T
L
S
A
I
Site 50
T387
E
G
S
I
S
P
R
T
L
S
A
I
K
R
A
Site 51
S389
S
I
S
P
R
T
L
S
A
I
K
R
A
L
D
Site 52
T411
C
A
G
D
D
V
Q
T
G
G
P
G
A
E
E
Site 53
S423
A
E
E
M
R
I
N
S
S
T
E
N
S
D
E
Site 54
S424
E
E
M
R
I
N
S
S
T
E
N
S
D
E
G
Site 55
T425
E
M
R
I
N
S
S
T
E
N
S
D
E
G
L
Site 56
S428
I
N
S
S
T
E
N
S
D
E
G
L
K
V
R
Site 57
T443
D
G
K
G
I
P
F
T
A
T
L
A
S
S
S
Site 58
S448
P
F
T
A
T
L
A
S
S
S
V
N
S
A
E
Site 59
S450
T
A
T
L
A
S
S
S
V
N
S
A
E
E
H
Site 60
S453
L
A
S
S
S
V
N
S
A
E
E
H
V
A
S
Site 61
S460
S
A
E
E
H
V
A
S
T
N
E
G
R
E
P
Site 62
T468
T
N
E
G
R
E
P
T
D
S
V
P
K
E
Q
Site 63
S470
E
G
R
E
P
T
D
S
V
P
K
E
Q
M
S
Site 64
S477
S
V
P
K
E
Q
M
S
L
V
H
V
G
T
E
Site 65
S489
G
T
E
A
F
P
I
S
D
E
S
M
I
K
D
Site 66
S505
K
D
R
L
P
L
E
S
A
V
V
R
H
S
D
Site 67
S511
E
S
A
V
V
R
H
S
D
A
P
G
L
P
N
Site 68
T523
L
P
N
G
R
E
L
T
P
A
S
P
T
C
T
Site 69
S526
G
R
E
L
T
P
A
S
P
T
C
T
N
S
V
Site 70
T528
E
L
T
P
A
S
P
T
C
T
N
S
V
S
K
Site 71
T530
T
P
A
S
P
T
C
T
N
S
V
S
K
N
E
Site 72
S532
A
S
P
T
C
T
N
S
V
S
K
N
E
T
H
Site 73
S534
P
T
C
T
N
S
V
S
K
N
E
T
H
A
E
Site 74
T538
N
S
V
S
K
N
E
T
H
A
E
V
L
E
Q
Site 75
Y552
Q
Q
N
E
L
C
P
Y
E
S
K
F
D
S
S
Site 76
S554
N
E
L
C
P
Y
E
S
K
F
D
S
S
L
L
Site 77
S558
P
Y
E
S
K
F
D
S
S
L
L
S
S
D
D
Site 78
S559
Y
E
S
K
F
D
S
S
L
L
S
S
D
D
E
Site 79
S562
K
F
D
S
S
L
L
S
S
D
D
E
T
K
C
Site 80
S563
F
D
S
S
L
L
S
S
D
D
E
T
K
C
K
Site 81
T567
L
L
S
S
D
D
E
T
K
C
K
P
N
S
A
Site 82
S573
E
T
K
C
K
P
N
S
A
S
E
V
I
G
P
Site 83
S575
K
C
K
P
N
S
A
S
E
V
I
G
P
V
S
Site 84
S588
V
S
L
Q
E
T
S
S
I
V
S
V
P
S
E
Site 85
S591
Q
E
T
S
S
I
V
S
V
P
S
E
A
V
D
Site 86
S605
D
N
V
E
N
V
V
S
F
N
A
K
E
H
E
Site 87
T624
T
I
Q
E
Q
Q
T
T
E
S
A
G
Q
D
L
Site 88
S633
S
A
G
Q
D
L
I
S
I
P
K
A
V
E
P
Site 89
S645
V
E
P
M
E
I
D
S
E
E
S
E
S
D
G
Site 90
S648
M
E
I
D
S
E
E
S
E
S
D
G
S
F
I
Site 91
S650
I
D
S
E
E
S
E
S
D
G
S
F
I
E
V
Site 92
S653
E
E
S
E
S
D
G
S
F
I
E
V
Q
S
V
Site 93
S662
I
E
V
Q
S
V
I
S
D
E
E
L
Q
A
E
Site 94
T673
L
Q
A
E
F
P
E
T
S
K
P
P
S
E
Q
Site 95
S674
Q
A
E
F
P
E
T
S
K
P
P
S
E
Q
G
Site 96
S678
P
E
T
S
K
P
P
S
E
Q
G
E
E
E
L
Site 97
T688
G
E
E
E
L
V
G
T
R
E
G
E
A
P
A
Site 98
S699
E
A
P
A
E
S
E
S
L
L
R
D
N
S
E
Site 99
S705
E
S
L
L
R
D
N
S
E
R
D
D
V
D
G
Site 100
S724
A
E
K
D
A
E
D
S
L
H
E
W
Q
D
I
Site 101
T738
I
N
L
E
E
L
E
T
L
E
S
N
L
L
A
Site 102
S741
E
E
L
E
T
L
E
S
N
L
L
A
Q
Q
N
Site 103
S749
N
L
L
A
Q
Q
N
S
L
K
A
Q
K
Q
Q
Site 104
S804
L
D
L
T
D
Q
T
S
G
T
I
T
D
D
S
Site 105
T808
D
Q
T
S
G
T
I
T
D
D
S
D
I
W
L
Site 106
Y822
L
F
G
A
R
H
V
Y
R
N
F
F
N
K
N
Site 107
Y835
K
N
K
F
V
E
Y
Y
Q
Y
V
D
F
H
N
Site 108
Y837
K
F
V
E
Y
Y
Q
Y
V
D
F
H
N
Q
L
Site 109
S860
N
L
A
Y
L
L
G
S
D
Y
T
E
G
I
P
Site 110
T912
I
R
P
N
P
H
D
T
K
V
K
K
K
L
R
Site 111
T920
K
V
K
K
K
L
R
T
L
Q
L
T
P
G
F
Site 112
T924
K
L
R
T
L
Q
L
T
P
G
F
P
N
P
A
Site 113
Y936
N
P
A
V
A
E
A
Y
L
K
P
V
V
D
D
Site 114
S944
L
K
P
V
V
D
D
S
K
G
S
F
L
W
G
Site 115
S947
V
V
D
D
S
K
G
S
F
L
W
G
K
P
D
Site 116
Y965
I
R
E
F
C
Q
R
Y
F
G
W
N
R
T
K
Site 117
T973
F
G
W
N
R
T
K
T
D
E
S
L
F
P
V
Site 118
S976
N
R
T
K
T
D
E
S
L
F
P
V
L
K
Q
Site 119
T989
K
Q
L
D
A
Q
Q
T
Q
L
R
I
D
S
F
Site 120
S995
Q
T
Q
L
R
I
D
S
F
F
R
L
A
Q
Q
Site 121
S1012
E
D
A
K
R
I
K
S
Q
R
L
N
R
A
V
Site 122
T1020
Q
R
L
N
R
A
V
T
C
M
L
R
K
E
K
Site 123
S1032
K
E
K
E
A
A
A
S
E
I
E
A
V
S
V
Site 124
T1061
K
T
Q
K
R
G
I
T
N
T
L
E
E
S
S
Site 125
T1063
Q
K
R
G
I
T
N
T
L
E
E
S
S
S
L
Site 126
S1069
N
T
L
E
E
S
S
S
L
K
R
K
R
L
S
Site 127
S1076
S
L
K
R
K
R
L
S
D
S
K
G
K
N
T
Site 128
S1078
K
R
K
R
L
S
D
S
K
G
K
N
T
C
G
Site 129
T1083
S
D
S
K
G
K
N
T
C
G
G
F
L
G
E
Site 130
T1091
C
G
G
F
L
G
E
T
C
L
S
E
S
S
D
Site 131
S1094
F
L
G
E
T
C
L
S
E
S
S
D
G
S
S
Site 132
S1096
G
E
T
C
L
S
E
S
S
D
G
S
S
S
E
Site 133
S1097
E
T
C
L
S
E
S
S
D
G
S
S
S
E
D
Site 134
S1100
L
S
E
S
S
D
G
S
S
S
E
D
A
E
S
Site 135
S1101
S
E
S
S
D
G
S
S
S
E
D
A
E
S
S
Site 136
S1102
E
S
S
D
G
S
S
S
E
D
A
E
S
S
S
Site 137
S1107
S
S
S
E
D
A
E
S
S
S
L
M
N
V
Q
Site 138
S1109
S
E
D
A
E
S
S
S
L
M
N
V
Q
R
R
Site 139
T1117
L
M
N
V
Q
R
R
T
A
A
K
E
P
K
T
Site 140
T1124
T
A
A
K
E
P
K
T
S
A
S
D
S
Q
N
Site 141
S1125
A
A
K
E
P
K
T
S
A
S
D
S
Q
N
S
Site 142
S1127
K
E
P
K
T
S
A
S
D
S
Q
N
S
V
K
Site 143
S1129
P
K
T
S
A
S
D
S
Q
N
S
V
K
E
A
Site 144
T1144
P
V
K
N
G
G
A
T
T
S
S
S
S
D
S
Site 145
T1145
V
K
N
G
G
A
T
T
S
S
S
S
D
S
D
Site 146
S1146
K
N
G
G
A
T
T
S
S
S
S
D
S
D
D
Site 147
S1147
N
G
G
A
T
T
S
S
S
S
D
S
D
D
D
Site 148
S1148
G
G
A
T
T
S
S
S
S
D
S
D
D
D
G
Site 149
S1149
G
A
T
T
S
S
S
S
D
S
D
D
D
G
G
Site 150
S1151
T
T
S
S
S
S
D
S
D
D
D
G
G
K
E
Site 151
S1167
M
V
L
V
T
A
R
S
V
F
G
K
K
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation