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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LAP3
Full Name:
Cytosol aminopeptidase
Alias:
AMPL; EC 3.4.11.1; EC 3.4.11.5; Leucine aminopeptidase; Peptidase S
Type:
Protease
Mass (Da):
56166
Number AA:
519
UniProt ID:
P28838
International Prot ID:
IPI00419237
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0000287
GO:0030145
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
L
A
V
R
R
F
G
S
R
S
L
S
T
A
D
Site 2
S26
V
R
R
F
G
S
R
S
L
S
T
A
D
M
T
Site 3
S28
R
F
G
S
R
S
L
S
T
A
D
M
T
K
G
Site 4
T29
F
G
S
R
S
L
S
T
A
D
M
T
K
G
L
Site 5
T33
S
L
S
T
A
D
M
T
K
G
L
V
L
G
I
Site 6
Y41
K
G
L
V
L
G
I
Y
S
K
E
K
E
D
D
Site 7
S42
G
L
V
L
G
I
Y
S
K
E
K
E
D
D
V
Site 8
S54
D
D
V
P
Q
F
T
S
A
G
E
N
F
D
K
Site 9
T70
L
A
G
K
L
R
E
T
L
N
I
S
G
P
P
Site 10
S74
L
R
E
T
L
N
I
S
G
P
P
L
K
A
G
Site 11
T83
P
P
L
K
A
G
K
T
R
T
F
Y
G
L
H
Site 12
T85
L
K
A
G
K
T
R
T
F
Y
G
L
H
Q
D
Site 13
Y87
A
G
K
T
R
T
F
Y
G
L
H
Q
D
F
P
Site 14
S139
I
Q
D
L
E
L
S
S
V
E
V
D
P
C
G
Site 15
Y160
E
G
A
V
L
G
L
Y
E
Y
D
D
L
K
Q
Site 16
Y162
A
V
L
G
L
Y
E
Y
D
D
L
K
Q
K
K
Site 17
S174
Q
K
K
K
M
A
V
S
A
K
L
Y
G
S
G
Site 18
Y178
M
A
V
S
A
K
L
Y
G
S
G
D
Q
E
A
Site 19
S180
V
S
A
K
L
Y
G
S
G
D
Q
E
A
W
Q
Site 20
T205
L
A
R
Q
L
M
E
T
P
A
N
E
M
T
P
Site 21
T211
E
T
P
A
N
E
M
T
P
T
R
F
A
E
I
Site 22
T213
P
A
N
E
M
T
P
T
R
F
A
E
I
I
E
Site 23
S225
I
I
E
K
N
L
K
S
A
S
S
K
T
E
V
Site 24
S227
E
K
N
L
K
S
A
S
S
K
T
E
V
H
I
Site 25
S228
K
N
L
K
S
A
S
S
K
T
E
V
H
I
R
Site 26
S238
E
V
H
I
R
P
K
S
W
I
E
E
Q
A
M
Site 27
S250
Q
A
M
G
S
F
L
S
V
A
K
G
S
D
E
Site 28
S269
L
E
I
H
Y
K
G
S
P
N
A
N
E
P
P
Site 29
T285
V
F
V
G
K
G
I
T
F
D
S
G
G
I
S
Site 30
S292
T
F
D
S
G
G
I
S
I
K
A
S
A
N
M
Site 31
S296
G
G
I
S
I
K
A
S
A
N
M
D
L
M
R
Site 32
T311
A
D
M
G
G
A
A
T
I
C
S
A
I
V
S
Site 33
S318
T
I
C
S
A
I
V
S
A
A
K
L
N
L
P
Site 34
S340
P
L
C
E
N
M
P
S
G
K
A
N
K
P
G
Site 35
T363
K
T
I
Q
V
D
N
T
D
A
E
G
R
L
I
Site 36
Y438
R
M
P
L
F
E
H
Y
T
R
Q
V
V
D
C
Site 37
Y456
D
V
N
N
I
G
K
Y
R
S
A
G
A
C
T
Site 38
T473
A
F
L
K
E
F
V
T
H
P
K
W
A
H
L
Site 39
Y494
T
N
K
D
E
V
P
Y
L
R
K
G
M
T
G
Site 40
T500
P
Y
L
R
K
G
M
T
G
R
P
T
R
T
L
Site 41
T504
K
G
M
T
G
R
P
T
R
T
L
I
E
F
L
Site 42
T506
M
T
G
R
P
T
R
T
L
I
E
F
L
L
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation