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Updated November 2019
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Protein Info
Short Name:
PCSK6
Full Name:
Proprotein convertase subtilisin/kexin type 6
Alias:
Paired basic amino acid cleaving enzyme 4;Subtilisin-like proprotein convertase 4;Subtilisin/kexin-like protease PACE4
Type:
Mass (Da):
106420
Number AA:
969
UniProt ID:
P29122
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
P
P
R
A
A
A
A
T
D
T
A
A
G
A
G
Site 2
Y70
A
P
P
P
R
P
V
Y
T
N
H
W
A
V
Q
Site 3
Y106
Q
I
G
N
L
E
D
Y
Y
H
F
Y
H
S
K
Site 4
Y107
I
G
N
L
E
D
Y
Y
H
F
Y
H
S
K
T
Site 5
Y110
L
E
D
Y
Y
H
F
Y
H
S
K
T
F
K
R
Site 6
T114
Y
H
F
Y
H
S
K
T
F
K
R
S
T
L
S
Site 7
S118
H
S
K
T
F
K
R
S
T
L
S
S
R
G
P
Site 8
T119
S
K
T
F
K
R
S
T
L
S
S
R
G
P
H
Site 9
S121
T
F
K
R
S
T
L
S
S
R
G
P
H
T
F
Site 10
S122
F
K
R
S
T
L
S
S
R
G
P
H
T
F
L
Site 11
T127
L
S
S
R
G
P
H
T
F
L
R
M
D
P
Q
Site 12
Y159
R
S
D
P
Q
A
L
Y
F
N
D
P
I
W
S
Site 13
S182
D
K
N
S
R
C
R
S
E
M
N
V
Q
A
A
Site 14
Y194
Q
A
A
W
K
R
G
Y
T
G
K
N
V
V
V
Site 15
T195
A
A
W
K
R
G
Y
T
G
K
N
V
V
V
T
Site 16
Y219
H
P
D
L
A
P
N
Y
D
S
Y
A
S
Y
D
Site 17
S221
D
L
A
P
N
Y
D
S
Y
A
S
Y
D
V
N
Site 18
Y222
L
A
P
N
Y
D
S
Y
A
S
Y
D
V
N
G
Site 19
Y225
N
Y
D
S
Y
A
S
Y
D
V
N
G
N
D
Y
Site 20
Y232
Y
D
V
N
G
N
D
Y
D
P
S
P
R
Y
D
Site 21
S235
N
G
N
D
Y
D
P
S
P
R
Y
D
A
S
N
Site 22
Y238
D
Y
D
P
S
P
R
Y
D
A
S
N
E
N
K
Site 23
S241
P
S
P
R
Y
D
A
S
N
E
N
K
H
G
T
Site 24
T284
R
M
L
D
G
D
V
T
D
V
V
E
A
K
S
Site 25
S291
T
D
V
V
E
A
K
S
L
G
I
R
P
N
Y
Site 26
Y298
S
L
G
I
R
P
N
Y
I
D
I
Y
S
A
S
Site 27
Y302
R
P
N
Y
I
D
I
Y
S
A
S
W
G
P
D
Site 28
T314
G
P
D
D
D
G
K
T
V
D
G
P
G
R
L
Site 29
Y328
L
A
K
Q
A
F
E
Y
G
I
K
K
G
R
Q
Site 30
S339
K
G
R
Q
G
L
G
S
I
F
V
W
A
S
G
Site 31
S345
G
S
I
F
V
W
A
S
G
N
G
G
R
E
G
Site 32
Y354
N
G
G
R
E
G
D
Y
C
S
C
D
G
Y
T
Site 33
Y360
D
Y
C
S
C
D
G
Y
T
N
S
I
Y
T
I
Site 34
S363
S
C
D
G
Y
T
N
S
I
Y
T
I
S
V
S
Site 35
Y365
D
G
Y
T
N
S
I
Y
T
I
S
V
S
S
A
Site 36
T366
G
Y
T
N
S
I
Y
T
I
S
V
S
S
A
T
Site 37
S368
T
N
S
I
Y
T
I
S
V
S
S
A
T
E
N
Site 38
S370
S
I
Y
T
I
S
V
S
S
A
T
E
N
G
Y
Site 39
Y381
E
N
G
Y
K
P
W
Y
L
E
E
C
A
S
T
Site 40
T388
Y
L
E
E
C
A
S
T
L
A
T
T
Y
S
S
Site 41
S394
S
T
L
A
T
T
Y
S
S
G
A
F
Y
E
R
Site 42
Y399
T
Y
S
S
G
A
F
Y
E
R
K
I
V
T
T
Site 43
T406
Y
E
R
K
I
V
T
T
D
L
R
Q
R
C
T
Site 44
T413
T
D
L
R
Q
R
C
T
D
G
H
T
G
T
S
Site 45
T452
V
Q
H
L
L
V
K
T
S
R
P
A
H
L
K
Site 46
S453
Q
H
L
L
V
K
T
S
R
P
A
H
L
K
A
Site 47
T494
V
V
E
A
K
K
W
T
A
V
P
S
Q
H
M
Site 48
S512
A
S
D
K
R
P
R
S
I
P
L
V
Q
V
L
Site 49
S532
T
S
A
C
A
E
H
S
D
Q
R
V
V
Y
L
Site 50
Y538
H
S
D
Q
R
V
V
Y
L
E
H
V
V
V
R
Site 51
S547
E
H
V
V
V
R
T
S
I
S
H
P
R
R
G
Site 52
S549
V
V
V
R
T
S
I
S
H
P
R
R
G
D
L
Site 53
Y559
R
R
G
D
L
Q
I
Y
L
V
S
P
S
G
T
Site 54
S562
D
L
Q
I
Y
L
V
S
P
S
G
T
K
S
Q
Site 55
S564
Q
I
Y
L
V
S
P
S
G
T
K
S
Q
L
L
Site 56
T566
Y
L
V
S
P
S
G
T
K
S
Q
L
L
A
K
Site 57
S568
V
S
P
S
G
T
K
S
Q
L
L
A
K
R
L
Site 58
S579
A
K
R
L
L
D
L
S
N
E
G
F
T
N
W
Site 59
T603
E
K
A
E
G
Q
W
T
L
E
I
Q
D
L
P
Site 60
S611
L
E
I
Q
D
L
P
S
Q
V
R
N
P
E
K
Site 61
S626
Q
G
K
L
K
E
W
S
L
I
L
Y
G
T
A
Site 62
Y630
K
E
W
S
L
I
L
Y
G
T
A
E
H
P
Y
Site 63
Y637
Y
G
T
A
E
H
P
Y
H
T
F
S
A
H
Q
Site 64
T639
T
A
E
H
P
Y
H
T
F
S
A
H
Q
S
R
Site 65
S641
E
H
P
Y
H
T
F
S
A
H
Q
S
R
S
R
Site 66
S645
H
T
F
S
A
H
Q
S
R
S
R
M
L
E
L
Site 67
S647
F
S
A
H
Q
S
R
S
R
M
L
E
L
S
A
Site 68
S653
R
S
R
M
L
E
L
S
A
P
E
L
E
P
P
Site 69
S665
E
P
P
K
A
A
L
S
P
S
Q
V
E
V
P
Site 70
S667
P
K
A
A
L
S
P
S
Q
V
E
V
P
E
D
Site 71
Y678
V
P
E
D
E
E
D
Y
T
A
Q
S
T
P
G
Site 72
T679
P
E
D
E
E
D
Y
T
A
Q
S
T
P
G
S
Site 73
S682
E
E
D
Y
T
A
Q
S
T
P
G
S
A
N
I
Site 74
T683
E
D
Y
T
A
Q
S
T
P
G
S
A
N
I
L
Site 75
S686
T
A
Q
S
T
P
G
S
A
N
I
L
Q
T
S
Site 76
S722
C
V
H
F
S
L
G
S
V
K
T
S
R
K
C
Site 77
S731
K
T
S
R
K
C
V
S
V
C
P
L
G
Y
F
Site 78
T741
P
L
G
Y
F
G
D
T
A
A
R
R
C
R
R
Site 79
T755
R
C
H
K
G
C
E
T
C
S
S
R
A
A
T
Site 80
S757
H
K
G
C
E
T
C
S
S
R
A
A
T
Q
C
Site 81
S758
K
G
C
E
T
C
S
S
R
A
A
T
Q
C
L
Site 82
T762
T
C
S
S
R
A
A
T
Q
C
L
S
C
R
R
Site 83
T815
V
D
E
P
E
K
C
T
V
C
K
E
G
F
S
Site 84
S827
G
F
S
L
A
R
G
S
C
I
P
D
C
E
P
Site 85
T836
I
P
D
C
E
P
G
T
Y
F
D
S
E
L
I
Site 86
Y837
P
D
C
E
P
G
T
Y
F
D
S
E
L
I
R
Site 87
S840
E
P
G
T
Y
F
D
S
E
L
I
R
C
G
E
Site 88
Y886
P
A
C
G
E
G
F
Y
P
E
E
M
P
G
L
Site 89
S907
R
C
D
E
N
C
L
S
C
A
G
S
S
R
N
Site 90
S911
N
C
L
S
C
A
G
S
S
R
N
C
S
R
C
Site 91
S916
A
G
S
S
R
N
C
S
R
C
K
T
G
F
T
Site 92
T920
R
N
C
S
R
C
K
T
G
F
T
Q
L
G
T
Site 93
T923
S
R
C
K
T
G
F
T
Q
L
G
T
S
C
I
Site 94
T927
T
G
F
T
Q
L
G
T
S
C
I
T
N
H
T
Site 95
T941
T
C
S
N
A
D
E
T
F
C
E
M
V
K
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation