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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TKT
Full Name:
Transketolase
Alias:
TK; TKT1; Transketolase variant; Wernicke-Korsakoff syndrome
Type:
EC 2.2.1.1; Transferase; Carbohydrate Metabolism - pentose phosphate pathway
Mass (Da):
67878
Number AA:
623
UniProt ID:
P29401
International Prot ID:
IPI00643920
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0044424
GO:0044444
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0004802
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
GO:0040008
GO:0050789
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
T
A
N
R
L
R
I
S
S
I
Q
A
T
T
A
Site 2
S26
A
N
R
L
R
I
S
S
I
Q
A
T
T
A
A
Site 3
T30
R
I
S
S
I
Q
A
T
T
A
A
G
S
G
H
Site 4
T31
I
S
S
I
Q
A
T
T
A
A
G
S
G
H
P
Site 5
T39
A
A
G
S
G
H
P
T
S
C
C
S
A
A
E
Site 6
S40
A
G
S
G
H
P
T
S
C
C
S
A
A
E
I
Site 7
Y58
L
F
F
H
T
M
R
Y
K
S
Q
D
P
R
N
Site 8
S104
L
L
N
L
R
K
I
S
S
D
L
D
G
H
P
Site 9
S105
L
N
L
R
K
I
S
S
D
L
D
G
H
P
V
Site 10
Y141
G
M
A
Y
T
G
K
Y
F
D
K
A
S
Y
R
Site 11
Y150
D
K
A
S
Y
R
V
Y
C
L
L
G
D
G
E
Site 12
S159
L
L
G
D
G
E
L
S
E
G
S
V
W
E
A
Site 13
S162
D
G
E
L
S
E
G
S
V
W
E
A
M
A
F
Site 14
S190
D
I
N
R
L
G
Q
S
D
P
A
P
L
Q
H
Site 15
Y202
L
Q
H
Q
M
D
I
Y
Q
K
R
C
E
A
F
Site 16
T249
T
F
K
G
R
G
I
T
G
V
E
D
K
E
S
Site 17
S256
T
G
V
E
D
K
E
S
W
H
G
K
P
L
P
Site 18
Y275
E
Q
I
I
Q
E
I
Y
S
Q
I
Q
S
K
K
Site 19
S276
Q
I
I
Q
E
I
Y
S
Q
I
Q
S
K
K
K
Site 20
S280
E
I
Y
S
Q
I
Q
S
K
K
K
I
L
A
T
Site 21
T287
S
K
K
K
I
L
A
T
P
P
Q
E
D
A
P
Site 22
S295
P
P
Q
E
D
A
P
S
V
D
I
A
N
I
R
Site 23
S305
I
A
N
I
R
M
P
S
L
P
S
Y
K
V
G
Site 24
S308
I
R
M
P
S
L
P
S
Y
K
V
G
D
K
I
Site 25
Y309
R
M
P
S
L
P
S
Y
K
V
G
D
K
I
A
Site 26
Y321
K
I
A
T
R
K
A
Y
G
Q
A
L
A
K
L
Site 27
T342
I
I
A
L
D
G
D
T
K
N
S
T
F
S
E
Site 28
S345
L
D
G
D
T
K
N
S
T
F
S
E
I
F
K
Site 29
T346
D
G
D
T
K
N
S
T
F
S
E
I
F
K
K
Site 30
Y363
P
D
R
F
I
E
C
Y
I
A
E
Q
N
M
V
Site 31
T382
G
C
A
T
R
N
R
T
V
P
F
C
S
T
F
Site 32
S387
N
R
T
V
P
F
C
S
T
F
A
A
F
F
T
Site 33
T388
R
T
V
P
F
C
S
T
F
A
A
F
F
T
R
Site 34
S420
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Site 35
S427
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
Site 36
S443
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
Site 37
T444
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
Site 38
Y447
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
Site 39
T472
K
G
I
C
F
I
R
T
S
R
P
E
N
A
I
Site 40
Y481
R
P
E
N
A
I
I
Y
N
N
N
E
D
F
Q
Site 41
S498
Q
A
K
V
V
L
K
S
K
D
D
Q
V
T
V
Site 42
T504
K
S
K
D
D
Q
V
T
V
I
G
A
G
V
T
Site 43
T536
I
R
V
L
D
P
F
T
I
K
P
L
D
R
K
Site 44
S548
D
R
K
L
I
L
D
S
A
R
A
T
K
G
R
Site 45
T558
A
T
K
G
R
I
L
T
V
E
D
H
Y
Y
E
Site 46
Y563
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
Site 47
Y564
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
Site 48
S595
A
V
N
R
V
P
R
S
G
K
P
A
E
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation