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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IL12A
Full Name:
Interleukin-12 subunit alpha
Alias:
CLMF; CLMF p35; Cytotoxic lymphocyte maturation factor 1, p35; Cytotoxic lymphocyte maturation factor 35 kDa; IL-12, subunit p35; IL-12A; Interleukin 12, p35; Interleukin 12A; Interleukin-12 alpha chain; Natural killer cell stimulatory factor 1, 35 kD subunit; Natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NKSF1; P35
Type:
Cytokine
Mass (Da):
24874
Number AA:
219
UniProt ID:
P29459
International Prot ID:
IPI00182737
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043514
Uniprot
OncoNet
Molecular Function:
GO:0005125
GO:0008083
GO:0005143
PhosphoSite+
KinaseNET
Biological Process:
GO:0007050
GO:0016477
GO:0050830
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T29
A
R
N
L
P
V
A
T
P
D
P
G
M
F
P
Site 2
S49
Q
N
L
L
R
A
V
S
N
M
L
Q
K
A
R
Site 3
T58
M
L
Q
K
A
R
Q
T
L
E
F
Y
P
C
T
Site 4
Y62
A
R
Q
T
L
E
F
Y
P
C
T
S
E
E
I
Site 5
T75
E
I
D
H
E
D
I
T
K
D
K
T
S
T
V
Site 6
T79
E
D
I
T
K
D
K
T
S
T
V
E
A
C
L
Site 7
T81
I
T
K
D
K
T
S
T
V
E
A
C
L
P
L
Site 8
T91
A
C
L
P
L
E
L
T
K
N
E
S
C
L
N
Site 9
S95
L
E
L
T
K
N
E
S
C
L
N
S
R
E
T
Site 10
S99
K
N
E
S
C
L
N
S
R
E
T
S
F
I
T
Site 11
T102
S
C
L
N
S
R
E
T
S
F
I
T
N
G
S
Site 12
S103
C
L
N
S
R
E
T
S
F
I
T
N
G
S
C
Site 13
S109
T
S
F
I
T
N
G
S
C
L
A
S
R
K
T
Site 14
S113
T
N
G
S
C
L
A
S
R
K
T
S
F
M
M
Site 15
Y134
I
Y
E
D
L
K
M
Y
Q
V
E
F
K
T
M
Site 16
T176
A
L
N
F
N
S
E
T
V
P
Q
K
S
S
L
Site 17
S181
S
E
T
V
P
Q
K
S
S
L
E
E
P
D
F
Site 18
S182
E
T
V
P
Q
K
S
S
L
E
E
P
D
F
Y
Site 19
Y189
S
L
E
E
P
D
F
Y
K
T
K
I
K
L
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation