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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Casp1
Full Name:
Caspase-1
Alias:
CASP-1; EC 3.4.22.36; ICE; IL-1 beta converting enzyme; IL-1BC; IL1BCE; Interleukin-1 beta convertase; Interleukin-1 beta converting enzyme; P45
Type:
Protease
Mass (Da):
45159
Number AA:
404
UniProt ID:
P29466
International Prot ID:
IsoformAlpha - IPI00021800
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008656
GO:0004197
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0043123
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
K
R
K
L
F
I
R
S
M
G
E
G
T
I
N
Site 2
T21
I
R
S
M
G
E
G
T
I
N
G
L
L
D
E
Site 3
T32
L
L
D
E
L
L
Q
T
R
V
L
N
K
E
E
Site 4
T54
N
A
T
V
M
D
K
T
R
A
L
I
D
S
V
Site 5
S60
K
T
R
A
L
I
D
S
V
I
P
K
G
A
Q
Site 6
S81
T
Y
I
C
E
E
D
S
Y
L
A
G
T
L
G
Site 7
S90
L
A
G
T
L
G
L
S
A
D
Q
T
S
G
N
Site 8
T94
L
G
L
S
A
D
Q
T
S
G
N
Y
L
N
M
Site 9
S104
N
Y
L
N
M
Q
D
S
Q
G
V
L
S
S
F
Site 10
S109
Q
D
S
Q
G
V
L
S
S
F
P
A
P
Q
A
Site 11
S110
D
S
Q
G
V
L
S
S
F
P
A
P
Q
A
V
Site 12
T125
Q
D
N
P
A
M
P
T
S
S
G
S
E
G
N
Site 13
S126
D
N
P
A
M
P
T
S
S
G
S
E
G
N
V
Site 14
S127
N
P
A
M
P
T
S
S
G
S
E
G
N
V
K
Site 15
S129
A
M
P
T
S
S
G
S
E
G
N
V
K
L
C
Site 16
S137
E
G
N
V
K
L
C
S
L
E
E
A
Q
R
I
Site 17
Y153
K
Q
K
S
A
E
I
Y
P
I
M
D
K
S
S
Site 18
S159
I
Y
P
I
M
D
K
S
S
R
T
R
L
A
L
Site 19
S160
Y
P
I
M
D
K
S
S
R
T
R
L
A
L
I
Site 20
S175
I
C
N
E
E
F
D
S
I
P
R
R
T
G
A
Site 21
T180
F
D
S
I
P
R
R
T
G
A
E
V
D
I
T
Site 22
S199
L
L
Q
N
L
G
Y
S
V
D
V
K
K
N
L
Site 23
S209
V
K
K
N
L
T
A
S
D
M
T
T
E
L
E
Site 24
T213
L
T
A
S
D
M
T
T
E
L
E
A
F
A
H
Site 25
T226
A
H
R
P
E
H
K
T
S
D
S
T
F
L
V
Site 26
S227
H
R
P
E
H
K
T
S
D
S
T
F
L
V
F
Site 27
S229
P
E
H
K
T
S
D
S
T
F
L
V
F
M
S
Site 28
T230
E
H
K
T
S
D
S
T
F
L
V
F
M
S
H
Site 29
S249
G
I
C
G
K
K
H
S
E
Q
V
P
D
I
L
Site 30
S272
L
N
T
K
N
C
P
S
L
K
D
K
P
K
V
Site 31
S289
I
Q
A
C
R
G
D
S
P
G
V
V
W
F
K
Site 32
S302
F
K
D
S
V
G
V
S
G
N
L
S
L
P
T
Site 33
T310
G
N
L
S
L
P
T
T
E
E
F
E
D
D
A
Site 34
S332
K
D
F
I
A
F
C
S
S
T
P
D
N
V
S
Site 35
T334
F
I
A
F
C
S
S
T
P
D
N
V
S
W
R
Site 36
S339
S
S
T
P
D
N
V
S
W
R
H
P
T
M
G
Site 37
T344
N
V
S
W
R
H
P
T
M
G
S
V
F
I
G
Site 38
Y360
L
I
E
H
M
Q
E
Y
A
C
S
C
D
V
E
Site 39
S376
I
F
R
K
V
R
F
S
F
E
Q
P
D
G
R
Site 40
T388
D
G
R
A
Q
M
P
T
T
E
R
V
T
L
T
Site 41
T389
G
R
A
Q
M
P
T
T
E
R
V
T
L
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation