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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
nNOS
Full Name:
Nitric oxide synthase, brain
Alias:
BNOS; Constitutive NOS; NC-NOS; Neuronal NOS; Nitric oxide synthase 1 (neuronal); Nitric-oxide synthase, brain; N-NOS; NOS; NOS, type I; NOS1
Type:
Oxidoreductase; Amino Acid Metabolism - arginine and proline; EC 1.14.13.39
Mass (Da):
160970
Number AA:
1434
UniProt ID:
P29475
International Prot ID:
IPI00217225
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0043197
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0050660
GO:0010181
GO:0050661
PhosphoSite+
KinaseNET
Biological Process:
GO:0006527
GO:0033555
GO:0007520
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
Q
I
Q
P
N
V
I
S
V
R
L
F
K
R
K
Site 2
S55
R
G
G
A
A
E
Q
S
G
L
I
Q
A
G
D
Site 3
S76
G
R
P
L
V
D
L
S
Y
D
S
A
L
E
V
Site 4
T105
R
G
P
E
G
F
T
T
H
L
E
T
T
F
T
Site 5
T110
F
T
T
H
L
E
T
T
F
T
G
D
G
T
P
Site 6
T112
T
H
L
E
T
T
F
T
G
D
G
T
P
K
T
Site 7
T116
T
T
F
T
G
D
G
T
P
K
T
I
R
V
T
Site 8
T119
T
G
D
G
T
P
K
T
I
R
V
T
Q
P
L
Site 9
T123
T
P
K
T
I
R
V
T
Q
P
L
G
P
P
T
Site 10
T130
T
Q
P
L
G
P
P
T
K
A
V
D
L
S
H
Site 11
S136
P
T
K
A
V
D
L
S
H
Q
P
P
A
G
K
Site 12
S153
P
L
A
V
D
G
A
S
G
P
G
N
G
P
Q
Site 13
Y163
G
N
G
P
Q
H
A
Y
D
D
G
Q
E
A
G
Site 14
S171
D
D
G
Q
E
A
G
S
L
P
H
A
N
G
L
Site 15
S195
A
K
K
A
T
R
V
S
L
Q
G
R
G
E
N
Site 16
S214
K
E
I
E
P
V
L
S
L
L
T
S
G
S
R
Site 17
S248
D
R
D
L
D
G
K
S
H
K
P
L
P
L
G
Site 18
S280
V
V
L
N
N
P
Y
S
E
K
E
Q
P
P
T
Site 19
T287
S
E
K
E
Q
P
P
T
S
G
K
Q
S
P
T
Site 20
S288
E
K
E
Q
P
P
T
S
G
K
Q
S
P
T
K
Site 21
S292
P
P
T
S
G
K
Q
S
P
T
K
N
G
S
P
Site 22
T294
T
S
G
K
Q
S
P
T
K
N
G
S
P
S
K
Site 23
S298
Q
S
P
T
K
N
G
S
P
S
K
C
P
R
F
Site 24
S300
P
T
K
N
G
S
P
S
K
C
P
R
F
L
K
Site 25
T318
W
E
T
E
V
V
L
T
D
T
L
H
L
K
S
Site 26
S325
T
D
T
L
H
L
K
S
T
L
E
T
G
C
T
Site 27
T329
H
L
K
S
T
L
E
T
G
C
T
E
Y
I
C
Site 28
S344
M
G
S
I
M
H
P
S
Q
H
A
R
R
P
E
Site 29
T355
R
R
P
E
D
V
R
T
K
G
Q
L
F
P
L
Site 30
Y370
A
K
E
F
I
D
Q
Y
Y
S
S
I
K
R
F
Site 31
Y371
K
E
F
I
D
Q
Y
Y
S
S
I
K
R
F
G
Site 32
S372
E
F
I
D
Q
Y
Y
S
S
I
K
R
F
G
S
Site 33
S373
F
I
D
Q
Y
Y
S
S
I
K
R
F
G
S
K
Site 34
S379
S
S
I
K
R
F
G
S
K
A
H
M
E
R
L
Site 35
T396
V
N
K
E
I
D
T
T
S
T
Y
Q
L
K
D
Site 36
T404
S
T
Y
Q
L
K
D
T
E
L
I
Y
G
A
K
Site 37
Y408
L
K
D
T
E
L
I
Y
G
A
K
H
A
W
R
Site 38
Y453
Y
I
C
N
H
V
K
Y
A
T
N
K
G
N
L
Site 39
Y490
Q
L
I
R
Y
A
G
Y
K
Q
P
D
G
S
T
Site 40
Y567
K
D
L
G
L
K
W
Y
G
L
P
A
V
S
N
Site 41
Y603
T
E
I
G
V
R
D
Y
C
D
N
S
R
Y
N
Site 42
Y609
D
Y
C
D
N
S
R
Y
N
I
L
E
E
V
A
Site 43
T626
M
N
L
D
M
R
K
T
S
S
L
W
K
D
Q
Site 44
S627
N
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
Site 45
S628
L
D
M
R
K
T
S
S
L
W
K
D
Q
A
L
Site 46
T652
S
F
Q
S
D
K
V
T
I
V
D
H
H
S
A
Site 47
S658
V
T
I
V
D
H
H
S
A
T
E
S
F
I
K
Site 48
T660
I
V
D
H
H
S
A
T
E
S
F
I
K
H
M
Site 49
Y671
I
K
H
M
E
N
E
Y
R
C
R
G
G
C
P
Site 50
T693
P
P
M
S
G
S
I
T
P
V
F
H
Q
E
M
Site 51
Y703
F
H
Q
E
M
L
N
Y
R
L
T
P
S
F
E
Site 52
T706
E
M
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
Site 53
S708
L
N
Y
R
L
T
P
S
F
E
Y
Q
P
D
P
Site 54
T724
N
T
H
V
W
K
G
T
N
G
T
P
T
K
R
Site 55
T727
V
W
K
G
T
N
G
T
P
T
K
R
R
A
I
Site 56
T729
K
G
T
N
G
T
P
T
K
R
R
A
I
G
F
Site 57
S746
L
A
E
A
V
K
F
S
A
K
L
M
G
Q
A
Site 58
Y764
R
V
K
A
T
I
L
Y
A
T
E
T
G
K
S
Site 59
T766
K
A
T
I
L
Y
A
T
E
T
G
K
S
Q
A
Site 60
T768
T
I
L
Y
A
T
E
T
G
K
S
Q
A
Y
A
Site 61
S771
Y
A
T
E
T
G
K
S
Q
A
Y
A
K
T
L
Site 62
T777
K
S
Q
A
Y
A
K
T
L
C
E
I
F
K
H
Site 63
Y796
K
V
M
S
M
E
E
Y
D
I
V
H
L
E
H
Site 64
S838
M
E
M
R
H
P
N
S
V
Q
E
E
R
K
S
Site 65
S845
S
V
Q
E
E
R
K
S
Y
K
V
R
F
N
S
Site 66
Y846
V
Q
E
E
R
K
S
Y
K
V
R
F
N
S
V
Site 67
S852
S
Y
K
V
R
F
N
S
V
S
S
Y
S
D
S
Site 68
S854
K
V
R
F
N
S
V
S
S
Y
S
D
S
Q
K
Site 69
S855
V
R
F
N
S
V
S
S
Y
S
D
S
Q
K
S
Site 70
S857
F
N
S
V
S
S
Y
S
D
S
Q
K
S
S
G
Site 71
S859
S
V
S
S
Y
S
D
S
Q
K
S
S
G
D
G
Site 72
S862
S
Y
S
D
S
Q
K
S
S
G
D
G
P
D
L
Site 73
S863
Y
S
D
S
Q
K
S
S
G
D
G
P
D
L
R
Site 74
S875
D
L
R
D
N
F
E
S
A
G
P
L
A
N
V
Site 75
T934
G
Q
E
E
A
F
R
T
W
A
K
K
V
F
K
Site 76
S961
N
I
E
K
A
N
N
S
L
I
S
N
D
R
S
Site 77
S964
K
A
N
N
S
L
I
S
N
D
R
S
W
K
R
Site 78
S968
S
L
I
S
N
D
R
S
W
K
R
N
K
F
R
Site 79
T977
K
R
N
K
F
R
L
T
F
V
A
E
A
P
E
Site 80
S990
P
E
L
T
Q
G
L
S
N
V
H
K
K
R
V
Site 81
S998
N
V
H
K
K
R
V
S
A
A
R
L
L
S
R
Site 82
S1004
V
S
A
A
R
L
L
S
R
Q
N
L
Q
S
P
Site 83
S1010
L
S
R
Q
N
L
Q
S
P
K
S
S
R
S
T
Site 84
S1013
Q
N
L
Q
S
P
K
S
S
R
S
T
I
F
V
Site 85
S1014
N
L
Q
S
P
K
S
S
R
S
T
I
F
V
R
Site 86
S1016
Q
S
P
K
S
S
R
S
T
I
F
V
R
L
H
Site 87
T1017
S
P
K
S
S
R
S
T
I
F
V
R
L
H
T
Site 88
T1024
T
I
F
V
R
L
H
T
N
G
S
Q
E
L
Q
Site 89
S1027
V
R
L
H
T
N
G
S
Q
E
L
Q
Y
Q
P
Site 90
Y1032
N
G
S
Q
E
L
Q
Y
Q
P
G
D
H
L
G
Site 91
T1076
E
L
L
E
E
R
N
T
A
L
G
V
I
S
N
Site 92
T1106
F
K
Y
Y
L
D
I
T
T
P
P
T
P
L
Q
Site 93
T1107
K
Y
Y
L
D
I
T
T
P
P
T
P
L
Q
L
Site 94
T1110
L
D
I
T
T
P
P
T
P
L
Q
L
Q
Q
F
Site 95
S1119
L
Q
L
Q
Q
F
A
S
L
A
T
S
E
K
E
Site 96
S1123
Q
F
A
S
L
A
T
S
E
K
E
K
Q
R
L
Site 97
S1134
K
Q
R
L
L
V
L
S
K
G
L
Q
E
Y
E
Site 98
Y1140
L
S
K
G
L
Q
E
Y
E
E
W
K
W
G
K
Site 99
Y1179
L
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
Site 100
Y1180
S
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
D
Site 101
S1181
L
L
Q
P
R
Y
Y
S
I
S
S
S
P
D
M
Site 102
S1183
Q
P
R
Y
Y
S
I
S
S
S
P
D
M
Y
P
Site 103
S1184
P
R
Y
Y
S
I
S
S
S
P
D
M
Y
P
D
Site 104
S1185
R
Y
Y
S
I
S
S
S
P
D
M
Y
P
D
E
Site 105
Y1189
I
S
S
S
P
D
M
Y
P
D
E
V
H
L
T
Site 106
S1201
H
L
T
V
A
I
V
S
Y
R
T
R
D
G
E
Site 107
S1238
C
F
V
R
G
A
P
S
F
H
L
P
R
N
P
Site 108
Y1297
Q
S
K
I
D
H
I
Y
R
E
E
T
L
Q
A
Site 109
T1301
D
H
I
Y
R
E
E
T
L
Q
A
K
N
K
G
Site 110
Y1314
K
G
V
F
R
E
L
Y
T
A
Y
S
R
E
P
Site 111
S1318
R
E
L
Y
T
A
Y
S
R
E
P
D
K
P
K
Site 112
Y1327
E
P
D
K
P
K
K
Y
V
Q
D
I
L
Q
E
Site 113
S1339
L
Q
E
Q
L
A
E
S
V
Y
R
A
L
K
E
Site 114
Y1352
K
E
Q
G
G
H
I
Y
V
C
G
D
V
T
M
Site 115
T1372
K
A
I
Q
R
I
M
T
Q
Q
G
K
L
S
A
Site 116
S1387
E
D
A
G
V
F
I
S
R
M
R
D
D
N
R
Site 117
Y1395
R
M
R
D
D
N
R
Y
H
E
D
I
F
G
V
Site 118
Y1407
F
G
V
T
L
R
T
Y
E
V
T
N
R
L
R
Site 119
T1410
T
L
R
T
Y
E
V
T
N
R
L
R
S
E
S
Site 120
S1415
E
V
T
N
R
L
R
S
E
S
I
A
F
I
E
Site 121
S1417
T
N
R
L
R
S
E
S
I
A
F
I
E
E
S
Site 122
T1428
I
E
E
S
K
K
D
T
D
E
V
F
S
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation