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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MARCKS
Full Name:
Myristoylated alanine-rich C-kinase substrate
Alias:
80K-L; 80K-L protein; MACS; MARCS; Myristoylated alanine-rich C-kinase substrate; Myristoylated alanine-rich protein kinase C substrate; PKCSL; PRKCSL; Protein kinase C substrate, 80 kDa protein, light chain
Type:
Actin binding protein
Mass (Da):
31555
Number AA:
332
UniProt ID:
P29966
International Prot ID:
IPI00219301
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0031225
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005516
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
G
A
Q
F
S
K
T
A
A
K
G
E
A
A
Site 2
S26
P
G
E
A
A
V
A
S
S
P
S
K
A
N
G
Site 3
S27
G
E
A
A
V
A
S
S
P
S
K
A
N
G
Q
Site 4
S29
A
A
V
A
S
S
P
S
K
A
N
G
Q
E
N
Site 5
S46
V
K
V
N
G
D
A
S
P
A
A
A
E
S
G
Site 6
S63
E
E
L
Q
A
N
G
S
A
P
A
A
D
K
E
Site 7
S77
E
E
P
A
A
A
G
S
G
A
A
S
P
S
A
Site 8
S81
A
A
G
S
G
A
A
S
P
S
A
A
E
K
G
Site 9
S83
G
S
G
A
A
S
P
S
A
A
E
K
G
E
P
Site 10
S101
A
A
P
E
A
G
A
S
P
V
E
K
E
A
P
Site 11
S118
G
E
A
A
E
P
G
S
P
T
A
A
E
G
E
Site 12
T120
A
A
E
P
G
S
P
T
A
A
E
G
E
A
A
Site 13
S128
A
A
E
G
E
A
A
S
A
A
S
S
T
S
S
Site 14
S131
G
E
A
A
S
A
A
S
S
T
S
S
P
K
A
Site 15
S132
E
A
A
S
A
A
S
S
T
S
S
P
K
A
E
Site 16
T133
A
A
S
A
A
S
S
T
S
S
P
K
A
E
D
Site 17
S134
A
S
A
A
S
S
T
S
S
P
K
A
E
D
G
Site 18
S135
S
A
A
S
S
T
S
S
P
K
A
E
D
G
A
Site 19
T143
P
K
A
E
D
G
A
T
P
S
P
S
N
E
T
Site 20
S145
A
E
D
G
A
T
P
S
P
S
N
E
T
P
K
Site 21
S147
D
G
A
T
P
S
P
S
N
E
T
P
K
K
K
Site 22
T150
T
P
S
P
S
N
E
T
P
K
K
K
K
K
R
Site 23
S159
K
K
K
K
K
R
F
S
F
K
K
S
F
K
L
Site 24
S163
K
R
F
S
F
K
K
S
F
K
L
S
G
F
S
Site 25
S167
F
K
K
S
F
K
L
S
G
F
S
F
K
K
N
Site 26
S170
S
F
K
L
S
G
F
S
F
K
K
N
K
K
E
Site 27
S252
A
P
E
K
P
P
A
S
D
E
T
K
A
A
E
Site 28
T255
K
P
P
A
S
D
E
T
K
A
A
E
E
P
S
Site 29
S262
T
K
A
A
E
E
P
S
K
V
E
E
K
K
A
Site 30
S275
K
A
E
E
A
G
A
S
A
A
A
C
E
A
P
Site 31
S314
S
S
A
C
A
A
P
S
Q
E
A
Q
P
E
C
Site 32
S322
Q
E
A
Q
P
E
C
S
P
E
A
P
P
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation