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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CNGA1
Full Name:
cGMP-gated cation channel alpha-1
Alias:
Cyclic nucleotide-gated cation channel 1;Cyclic nucleotide-gated channel alpha-1;Cyclic nucleotide-gated channel, photoreceptor;Rod photoreceptor cGMP-gated channel subunit alpha
Type:
Channel protein
Mass (Da):
79126
Number AA:
686
UniProt ID:
P29973
International Prot ID:
IPI00218428
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0030553
GO:0005216
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
GO:0050896
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S41
M
E
N
G
A
C
S
S
F
S
E
D
D
D
S
Site 2
S43
N
G
A
C
S
S
F
S
E
D
D
D
S
A
S
Site 3
S48
S
F
S
E
D
D
D
S
A
S
T
S
E
E
S
Site 4
S50
S
E
D
D
D
S
A
S
T
S
E
E
S
E
N
Site 5
S52
D
D
D
S
A
S
T
S
E
E
S
E
N
E
N
Site 6
S55
S
A
S
T
S
E
E
S
E
N
E
N
P
H
A
Site 7
S65
E
N
P
H
A
R
G
S
F
S
Y
K
S
L
R
Site 8
S67
P
H
A
R
G
S
F
S
Y
K
S
L
R
K
G
Site 9
Y68
H
A
R
G
S
F
S
Y
K
S
L
R
K
G
G
Site 10
S70
R
G
S
F
S
Y
K
S
L
R
K
G
G
P
S
Site 11
S77
S
L
R
K
G
G
P
S
Q
R
E
Q
Y
L
P
Site 12
Y82
G
P
S
Q
R
E
Q
Y
L
P
G
A
I
A
L
Site 13
S114
K
K
K
K
E
K
K
S
K
S
D
D
K
N
E
Site 14
S116
K
K
E
K
K
S
K
S
D
D
K
N
E
N
K
Site 15
S144
K
K
K
K
E
E
K
S
K
D
K
K
E
E
E
Site 16
Y165
I
D
P
S
G
N
T
Y
Y
N
W
L
F
C
I
Site 17
Y166
D
P
S
G
N
T
Y
Y
N
W
L
F
C
I
T
Site 18
Y196
F
D
E
L
Q
S
D
Y
L
E
Y
W
L
I
L
Site 19
T221
D
M
F
V
R
T
R
T
G
Y
L
E
Q
G
L
Site 20
Y223
F
V
R
T
R
T
G
Y
L
E
Q
G
L
L
V
Site 21
Y240
E
L
K
L
I
N
K
Y
K
S
N
L
Q
F
K
Site 22
S242
K
L
I
N
K
Y
K
S
N
L
Q
F
K
L
D
Site 23
Y267
Y
F
K
L
G
W
N
Y
P
E
I
R
L
N
R
Site 24
S279
L
N
R
L
L
R
F
S
R
M
F
E
F
F
Q
Site 25
T290
E
F
F
Q
R
T
E
T
R
T
N
Y
P
N
I
Site 26
T292
F
Q
R
T
E
T
R
T
N
Y
P
N
I
F
R
Site 27
Y294
R
T
E
T
R
T
N
Y
P
N
I
F
R
I
S
Site 28
Y334
F
G
N
D
T
W
V
Y
P
D
I
N
D
P
E
Site 29
Y349
F
G
R
L
A
R
K
Y
V
Y
S
L
Y
W
S
Site 30
Y351
R
L
A
R
K
Y
V
Y
S
L
Y
W
S
T
L
Site 31
S352
L
A
R
K
Y
V
Y
S
L
Y
W
S
T
L
T
Site 32
Y354
R
K
Y
V
Y
S
L
Y
W
S
T
L
T
L
T
Site 33
T366
T
L
T
T
I
G
E
T
P
P
P
V
R
D
S
Site 34
Y420
R
I
D
A
I
K
Q
Y
M
H
F
R
N
V
S
Site 35
Y440
R
V
I
K
W
F
D
Y
L
W
T
N
K
K
T
Site 36
T447
Y
L
W
T
N
K
K
T
V
D
E
K
E
V
L
Site 37
Y456
D
E
K
E
V
L
K
Y
L
P
D
K
L
R
A
Site 38
Y500
L
K
L
Q
P
Q
V
Y
S
P
G
D
Y
I
C
Site 39
S501
K
L
Q
P
Q
V
Y
S
P
G
D
Y
I
C
K
Site 40
Y505
Q
V
Y
S
P
G
D
Y
I
C
K
K
G
D
I
Site 41
Y517
G
D
I
G
R
E
M
Y
I
I
K
E
G
K
L
Site 42
S555
S
I
L
N
I
K
G
S
K
A
G
N
R
R
T
Site 43
T562
S
K
A
G
N
R
R
T
A
N
I
K
S
I
G
Site 44
S567
R
R
T
A
N
I
K
S
I
G
Y
S
D
L
F
Site 45
S577
Y
S
D
L
F
C
L
S
K
D
D
L
M
E
A
Site 46
T586
D
D
L
M
E
A
L
T
E
Y
P
D
A
K
T
Site 47
Y588
L
M
E
A
L
T
E
Y
P
D
A
K
T
M
L
Site 48
T593
T
E
Y
P
D
A
K
T
M
L
E
E
K
G
K
Site 49
S618
L
N
I
A
N
A
G
S
D
P
K
D
L
E
E
Site 50
T628
K
D
L
E
E
K
V
T
R
M
E
G
S
V
D
Site 51
S633
K
V
T
R
M
E
G
S
V
D
L
L
Q
T
R
Site 52
Y648
F
A
R
I
L
A
E
Y
E
S
M
Q
Q
K
L
Site 53
S650
R
I
L
A
E
Y
E
S
M
Q
Q
K
L
K
Q
Site 54
T660
Q
K
L
K
Q
R
L
T
K
V
E
K
F
L
K
Site 55
S676
L
I
D
T
E
F
S
S
I
E
G
P
G
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation