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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALDH4A1
Full Name:
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Alias:
AL4A1; aldehyde dehydrogenase 4 family, member A1; Aldehyde dehydrogenase 4A1; ALDH4; Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; P5C dehydrogenase; P5CDh
Type:
Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 1.5.1.12; Oxidoreductase
Mass (Da):
61720
Number AA:
UniProt ID:
P30038
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0003842
GO:0004029
GO:0009055
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0006561
GO:0006562
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
L
R
R
A
L
L
S
R
P
W
T
G
A
G
Site 2
T18
A
L
L
S
R
P
W
T
G
A
G
L
R
W
K
Site 3
T27
A
G
L
R
W
K
H
T
S
S
L
K
V
A
N
Site 4
S28
G
L
R
W
K
H
T
S
S
L
K
V
A
N
E
Site 5
S29
L
R
W
K
H
T
S
S
L
K
V
A
N
E
P
Site 6
S44
V
L
A
F
T
Q
G
S
P
E
R
D
A
L
Q
Site 7
T75
V
G
D
E
E
V
W
T
S
D
V
Q
Y
Q
V
Site 8
S76
G
D
E
E
V
W
T
S
D
V
Q
Y
Q
V
S
Site 9
Y80
V
W
T
S
D
V
Q
Y
Q
V
S
P
F
N
H
Site 10
S83
S
D
V
Q
Y
Q
V
S
P
F
N
H
G
H
K
Site 11
Y96
H
K
V
A
K
F
C
Y
A
D
K
S
L
L
N
Site 12
S100
K
F
C
Y
A
D
K
S
L
L
N
K
A
I
E
Site 13
S136
L
K
A
A
D
M
L
S
G
P
R
R
A
E
I
Site 14
T147
R
A
E
I
L
A
K
T
M
V
G
Q
G
K
T
Site 15
Y176
F
F
R
F
N
A
K
Y
A
V
E
L
E
G
Q
Site 16
S187
L
E
G
Q
Q
P
I
S
V
P
P
S
T
N
S
Site 17
S191
Q
P
I
S
V
P
P
S
T
N
S
T
V
Y
R
Site 18
T192
P
I
S
V
P
P
S
T
N
S
T
V
Y
R
G
Site 19
S194
S
V
P
P
S
T
N
S
T
V
Y
R
G
L
E
Site 20
T195
V
P
P
S
T
N
S
T
V
Y
R
G
L
E
G
Site 21
T272
D
G
P
L
F
G
D
T
V
T
S
S
E
H
L
Site 22
T274
P
L
F
G
D
T
V
T
S
S
E
H
L
C
G
Site 23
S276
F
G
D
T
V
T
S
S
E
H
L
C
G
I
N
Site 24
T307
Q
N
L
D
R
F
H
T
F
P
R
L
A
G
E
Site 25
S326
N
F
H
F
V
H
R
S
A
D
V
E
S
V
V
Site 26
S331
H
R
S
A
D
V
E
S
V
V
S
G
T
L
R
Site 27
T336
V
E
S
V
V
S
G
T
L
R
S
A
F
E
Y
Site 28
S339
V
V
S
G
T
L
R
S
A
F
E
Y
G
G
Q
Site 29
Y343
T
L
R
S
A
F
E
Y
G
G
Q
K
C
S
A
Site 30
S359
S
R
L
Y
V
P
H
S
L
W
P
Q
I
K
G
Site 31
S373
G
R
L
L
E
E
H
S
R
I
K
V
G
D
P
Site 32
S396
S
A
V
I
D
A
K
S
F
A
R
I
K
K
W
Site 33
S409
K
W
L
E
H
A
R
S
S
P
S
L
T
I
L
Site 34
S410
W
L
E
H
A
R
S
S
P
S
L
T
I
L
A
Site 35
S412
E
H
A
R
S
S
P
S
L
T
I
L
A
G
G
Site 36
S424
A
G
G
K
C
D
D
S
V
G
Y
F
V
E
P
Site 37
S436
V
E
P
C
I
V
E
S
K
D
P
Q
E
P
I
Site 38
Y456
F
G
P
V
L
S
V
Y
V
Y
P
D
D
K
Y
Site 39
Y458
P
V
L
S
V
Y
V
Y
P
D
D
K
Y
K
E
Site 40
Y463
Y
V
Y
P
D
D
K
Y
K
E
T
L
Q
L
V
Site 41
S472
E
T
L
Q
L
V
D
S
T
T
S
Y
G
L
T
Site 42
T473
T
L
Q
L
V
D
S
T
T
S
Y
G
L
T
G
Site 43
T479
S
T
T
S
Y
G
L
T
G
A
V
F
S
Q
D
Site 44
Y505
R
N
A
A
G
N
F
Y
I
N
D
K
S
T
G
Site 45
S510
N
F
Y
I
N
D
K
S
T
G
S
I
V
G
Q
Site 46
T511
F
Y
I
N
D
K
S
T
G
S
I
V
G
Q
Q
Site 47
S513
I
N
D
K
S
T
G
S
I
V
G
Q
Q
P
F
Site 48
S526
P
F
G
G
A
R
A
S
G
T
N
D
K
P
G
Site 49
T528
G
G
A
R
A
S
G
T
N
D
K
P
G
G
P
Site 50
Y537
D
K
P
G
G
P
H
Y
I
L
R
W
T
S
P
Site 51
T542
P
H
Y
I
L
R
W
T
S
P
Q
V
I
K
E
Site 52
S543
H
Y
I
L
R
W
T
S
P
Q
V
I
K
E
T
Site 53
T550
S
P
Q
V
I
K
E
T
H
K
P
L
G
D
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation