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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPP2R1A
Full Name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Alias:
2AAA; Medium tumor antigen-associated 61 kDa protein; PP2A, A, PR65-alpha isoform; PP2A, A, R1-alpha isoform; PP2A, subunit A, PR65-alpha isoform; PR65A; Protein phosphatase 2 (formerly 2A) regulatory subunit A, alpha isoform
Type:
Mass (Da):
65309
Number AA:
589
UniProt ID:
P30153
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016020
GO:0015630
Uniprot
OncoNet
Molecular Function:
GO:0003823
GO:0046982
GO:0008601
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006672
GO:0000188
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
A
A
D
G
D
D
S
L
Y
P
I
A
V
L
Site 2
S31
D
V
Q
L
R
L
N
S
I
K
K
L
S
T
I
Site 3
T56
S
E
L
L
P
F
L
T
D
T
I
Y
D
E
D
Site 4
T78
E
Q
L
G
T
F
T
T
L
V
G
G
P
E
Y
Site 5
S111
V
R
D
K
A
V
E
S
L
R
A
I
S
H
E
Site 6
S116
V
E
S
L
R
A
I
S
H
E
H
S
P
S
D
Site 7
S120
R
A
I
S
H
E
H
S
P
S
D
L
E
A
H
Site 8
S122
I
S
H
E
H
S
P
S
D
L
E
A
H
F
V
Site 9
T142
L
A
G
G
D
W
F
T
S
R
T
S
A
C
G
Site 10
S143
A
G
G
D
W
F
T
S
R
T
S
A
C
G
L
Site 11
S160
V
C
Y
P
R
V
S
S
A
V
K
A
E
L
R
Site 12
Y169
V
K
A
E
L
R
Q
Y
F
R
N
L
C
S
D
Site 13
T178
R
N
L
C
S
D
D
T
P
M
V
R
R
A
A
Site 14
S187
M
V
R
R
A
A
A
S
K
L
G
E
F
A
K
Site 15
S210
S
E
I
I
P
M
F
S
N
L
A
S
D
E
Q
Site 16
S214
P
M
F
S
N
L
A
S
D
E
Q
D
S
V
R
Site 17
S219
L
A
S
D
E
Q
D
S
V
R
L
L
A
V
E
Site 18
Y261
D
K
S
W
R
V
R
Y
M
V
A
D
K
F
T
Site 19
S314
K
E
F
C
E
N
L
S
A
D
C
R
E
N
V
Site 20
S335
P
C
I
K
E
L
V
S
D
A
N
Q
H
V
K
Site 21
S343
D
A
N
Q
H
V
K
S
A
L
A
S
V
I
M
Site 22
S386
E
V
R
L
N
I
I
S
N
L
D
C
V
N
E
Site 23
S464
A
I
R
E
A
A
T
S
N
L
K
K
L
V
E
Site 24
Y495
A
M
S
G
D
P
N
Y
L
H
R
M
T
T
L
Site 25
S554
I
G
P
I
L
D
N
S
T
L
Q
S
E
V
K
Site 26
T555
G
P
I
L
D
N
S
T
L
Q
S
E
V
K
P
Site 27
S558
L
D
N
S
T
L
Q
S
E
V
K
P
I
L
E
Site 28
Y577
D
Q
D
V
D
V
K
Y
F
A
Q
E
A
L
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation