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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cdc27
Full Name:
Cell division cycle protein 27 homolog
Alias:
CDC27Hs; H-NUC
Type:
Cell cycle protein
Mass (Da):
91867
Number AA:
824
UniProt ID:
P30260
International Prot ID:
IPI00294575
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005680
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031145
GO:0008283
GO:0007091
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y32
V
F
L
A
E
R
L
Y
A
E
V
H
S
E
E
Site 2
Y49
F
L
L
A
T
C
Y
Y
R
S
G
K
A
Y
K
Site 3
Y55
Y
Y
R
S
G
K
A
Y
K
A
Y
R
L
L
K
Site 4
Y58
S
G
K
A
Y
K
A
Y
R
L
L
K
G
H
S
Site 5
S65
Y
R
L
L
K
G
H
S
C
T
T
P
Q
C
K
Site 6
T68
L
K
G
H
S
C
T
T
P
Q
C
K
Y
L
L
Site 7
S83
A
K
C
C
V
D
L
S
K
L
A
E
G
E
Q
Site 8
S93
A
E
G
E
Q
I
L
S
G
G
V
F
N
K
Q
Site 9
S102
G
V
F
N
K
Q
K
S
H
D
D
I
V
T
E
Site 10
T108
K
S
H
D
D
I
V
T
E
F
G
D
S
A
C
Site 11
T128
L
G
H
V
Y
C
K
T
D
R
L
A
K
G
S
Site 12
S135
T
D
R
L
A
K
G
S
E
C
Y
Q
K
S
L
Site 13
S141
G
S
E
C
Y
Q
K
S
L
S
L
N
P
F
L
Site 14
S143
E
C
Y
Q
K
S
L
S
L
N
P
F
L
W
S
Site 15
S150
S
L
N
P
F
L
W
S
P
F
E
S
L
C
E
Site 16
S154
F
L
W
S
P
F
E
S
L
C
E
I
G
E
K
Site 17
T167
E
K
P
D
P
D
Q
T
F
K
F
T
S
L
Q
Site 18
S177
F
T
S
L
Q
N
F
S
N
C
L
P
N
S
C
Site 19
S183
F
S
N
C
L
P
N
S
C
T
T
Q
V
P
N
Site 20
T186
C
L
P
N
S
C
T
T
Q
V
P
N
H
S
L
Site 21
S192
T
T
Q
V
P
N
H
S
L
S
H
R
Q
P
E
Site 22
S194
Q
V
P
N
H
S
L
S
H
R
Q
P
E
T
V
Site 23
T200
L
S
H
R
Q
P
E
T
V
L
T
E
T
P
Q
Site 24
T203
R
Q
P
E
T
V
L
T
E
T
P
Q
D
T
I
Site 25
T205
P
E
T
V
L
T
E
T
P
Q
D
T
I
E
L
Site 26
T209
L
T
E
T
P
Q
D
T
I
E
L
N
R
L
N
Site 27
S219
L
N
R
L
N
L
E
S
S
N
S
K
Y
S
L
Site 28
S220
N
R
L
N
L
E
S
S
N
S
K
Y
S
L
N
Site 29
S222
L
N
L
E
S
S
N
S
K
Y
S
L
N
T
D
Site 30
Y224
L
E
S
S
N
S
K
Y
S
L
N
T
D
S
S
Site 31
S225
E
S
S
N
S
K
Y
S
L
N
T
D
S
S
V
Site 32
T228
N
S
K
Y
S
L
N
T
D
S
S
V
S
Y
I
Site 33
S231
Y
S
L
N
T
D
S
S
V
S
Y
I
D
S
A
Site 34
Y234
N
T
D
S
S
V
S
Y
I
D
S
A
V
I
S
Site 35
S241
Y
I
D
S
A
V
I
S
P
D
T
V
P
L
G
Site 36
T244
S
A
V
I
S
P
D
T
V
P
L
G
T
G
T
Site 37
S252
V
P
L
G
T
G
T
S
I
L
S
K
Q
V
Q
Site 38
S255
G
T
G
T
S
I
L
S
K
Q
V
Q
N
K
P
Site 39
T264
Q
V
Q
N
K
P
K
T
G
R
S
L
L
G
G
Site 40
S267
N
K
P
K
T
G
R
S
L
L
G
G
P
A
A
Site 41
S276
L
G
G
P
A
A
L
S
P
L
T
P
S
F
G
Site 42
T279
P
A
A
L
S
P
L
T
P
S
F
G
I
L
P
Site 43
T289
F
G
I
L
P
L
E
T
P
S
P
G
D
G
S
Site 44
S291
I
L
P
L
E
T
P
S
P
G
D
G
S
Y
L
Site 45
S296
T
P
S
P
G
D
G
S
Y
L
Q
N
Y
T
N
Site 46
Y297
P
S
P
G
D
G
S
Y
L
Q
N
Y
T
N
T
Site 47
Y301
D
G
S
Y
L
Q
N
Y
T
N
T
P
P
V
I
Site 48
T302
G
S
Y
L
Q
N
Y
T
N
T
P
P
V
I
D
Site 49
T304
Y
L
Q
N
Y
T
N
T
P
P
V
I
D
V
P
Site 50
S312
P
P
V
I
D
V
P
S
T
G
A
P
S
K
K
Site 51
T313
P
V
I
D
V
P
S
T
G
A
P
S
K
K
S
Site 52
S320
T
G
A
P
S
K
K
S
V
A
R
I
G
Q
T
Site 53
T327
S
V
A
R
I
G
Q
T
G
T
K
S
V
F
S
Site 54
T329
A
R
I
G
Q
T
G
T
K
S
V
F
S
Q
S
Site 55
S331
I
G
Q
T
G
T
K
S
V
F
S
Q
S
G
N
Site 56
S334
T
G
T
K
S
V
F
S
Q
S
G
N
S
R
E
Site 57
S336
T
K
S
V
F
S
Q
S
G
N
S
R
E
V
T
Site 58
S339
V
F
S
Q
S
G
N
S
R
E
V
T
P
I
L
Site 59
T343
S
G
N
S
R
E
V
T
P
I
L
A
Q
T
Q
Site 60
T349
V
T
P
I
L
A
Q
T
Q
S
S
G
P
Q
T
Site 61
S351
P
I
L
A
Q
T
Q
S
S
G
P
Q
T
S
T
Site 62
T356
T
Q
S
S
G
P
Q
T
S
T
T
P
Q
V
L
Site 63
S357
Q
S
S
G
P
Q
T
S
T
T
P
Q
V
L
S
Site 64
T358
S
S
G
P
Q
T
S
T
T
P
Q
V
L
S
P
Site 65
T359
S
G
P
Q
T
S
T
T
P
Q
V
L
S
P
T
Site 66
S364
S
T
T
P
Q
V
L
S
P
T
I
T
S
P
P
Site 67
T366
T
P
Q
V
L
S
P
T
I
T
S
P
P
N
A
Site 68
T368
Q
V
L
S
P
T
I
T
S
P
P
N
A
L
P
Site 69
S369
V
L
S
P
T
I
T
S
P
P
N
A
L
P
R
Site 70
S378
P
N
A
L
P
R
R
S
S
R
L
F
T
S
D
Site 71
S379
N
A
L
P
R
R
S
S
R
L
F
T
S
D
S
Site 72
T383
R
R
S
S
R
L
F
T
S
D
S
S
T
T
K
Site 73
S384
R
S
S
R
L
F
T
S
D
S
S
T
T
K
E
Site 74
S386
S
R
L
F
T
S
D
S
S
T
T
K
E
N
S
Site 75
S387
R
L
F
T
S
D
S
S
T
T
K
E
N
S
K
Site 76
T388
L
F
T
S
D
S
S
T
T
K
E
N
S
K
K
Site 77
T389
F
T
S
D
S
S
T
T
K
E
N
S
K
K
L
Site 78
S393
S
S
T
T
K
E
N
S
K
K
L
K
M
K
F
Site 79
T409
P
K
I
P
N
R
K
T
K
S
K
T
N
K
G
Site 80
S411
I
P
N
R
K
T
K
S
K
T
N
K
G
G
I
Site 81
S426
T
Q
P
N
I
N
D
S
L
E
I
T
K
L
D
Site 82
T430
I
N
D
S
L
E
I
T
K
L
D
S
S
I
I
Site 83
S434
L
E
I
T
K
L
D
S
S
I
I
S
E
G
K
Site 84
S435
E
I
T
K
L
D
S
S
I
I
S
E
G
K
I
Site 85
S438
K
L
D
S
S
I
I
S
E
G
K
I
S
T
I
Site 86
T444
I
S
E
G
K
I
S
T
I
T
P
Q
I
Q
A
Site 87
T446
E
G
K
I
S
T
I
T
P
Q
I
Q
A
F
N
Site 88
Y473
L
R
E
M
G
K
G
Y
L
A
L
C
S
Y
N
Site 89
S489
K
E
A
I
N
I
L
S
H
L
P
S
H
H
Y
Site 90
S513
G
R
A
Y
F
E
L
S
E
Y
M
Q
A
E
R
Site 91
Y515
A
Y
F
E
L
S
E
Y
M
Q
A
E
R
I
F
Site 92
S523
M
Q
A
E
R
I
F
S
E
V
R
R
I
E
N
Site 93
Y531
E
V
R
R
I
E
N
Y
R
V
E
G
M
E
I
Site 94
Y539
R
V
E
G
M
E
I
Y
S
T
T
L
W
H
L
Site 95
S553
L
Q
K
D
V
A
L
S
V
L
S
K
D
L
T
Site 96
T560
S
V
L
S
K
D
L
T
D
M
D
K
N
S
P
Site 97
S566
L
T
D
M
D
K
N
S
P
E
A
W
C
A
A
Site 98
S578
C
A
A
G
N
C
F
S
L
Q
R
E
H
D
I
Site 99
Y602
Q
V
D
P
N
Y
A
Y
A
Y
T
L
L
G
H
Site 100
Y635
I
R
V
N
P
R
H
Y
N
A
W
Y
G
L
G
Site 101
Y645
W
Y
G
L
G
M
I
Y
Y
K
Q
E
K
F
S
Site 102
Y646
Y
G
L
G
M
I
Y
Y
K
Q
E
K
F
S
L
Site 103
T691
K
S
E
K
A
L
D
T
L
N
K
A
I
V
I
Site 104
S711
L
C
K
F
H
R
A
S
V
L
F
A
N
E
K
Site 105
S721
F
A
N
E
K
Y
K
S
A
L
Q
E
L
E
E
Site 106
Y740
V
P
K
E
S
L
V
Y
F
L
I
G
K
V
Y
Site 107
Y747
Y
F
L
I
G
K
V
Y
K
K
L
G
Q
T
H
Site 108
Y783
K
E
A
I
D
K
R
Y
L
P
D
D
E
E
P
Site 109
T792
P
D
D
E
E
P
I
T
Q
E
E
Q
I
M
G
Site 110
S803
Q
I
M
G
T
D
E
S
Q
E
S
S
M
T
D
Site 111
S806
G
T
D
E
S
Q
E
S
S
M
T
D
A
D
D
Site 112
S807
T
D
E
S
Q
E
S
S
M
T
D
A
D
D
T
Site 113
T809
E
S
Q
E
S
S
M
T
D
A
D
D
T
Q
L
Site 114
T814
S
M
T
D
A
D
D
T
Q
L
H
A
A
E
S
Site 115
S821
T
Q
L
H
A
A
E
S
D
E
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation