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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CDC25A
Full Name:
M-phase inducer phosphatase 1
Alias:
CDC25M3; EC 3.1.3.48; M-phase inducer phosphatase 1; MPIP1
Type:
Protein-tyrosine phosphatase
Mass (Da):
59087
Number AA:
523
UniProt ID:
P30304
International Prot ID:
IPI00220981
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006260
GO:0051301
GO:0008283
Phosida
TranscriptoNet
STRING
Kinexus Products
Cell division cycle 25A phosphatase pan-specific antibody AB-NP038-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP038-1#Cell division cycle 25A phosphatase pan-specific antibody AB-NP038-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP038-2#Cell division cycle 25A phosphatase pan-specific antibody AB-NP038-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP038-3#Cell division cycle 25A phosphatase (M1-L14, human) peptide - Powder PE-01AZN99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZN99#Cell division cycle 25A phosphatase (G339-K353, human) peptide - Powder PE-01AZO95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZO95#Cell division cycle 25A phosphatase (A509-K523, human) peptide - Powder PE-01AZP90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AZP90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
R
R
L
L
F
A
C
S
P
P
P
A
S
Q
P
Site 2
S57
D
Q
L
Q
G
L
G
S
D
Y
E
Q
P
L
E
Site 3
Y59
L
Q
G
L
G
S
D
Y
E
Q
P
L
E
V
K
Site 4
S76
S
N
L
Q
R
M
G
S
S
E
S
T
D
S
G
Site 5
S79
Q
R
M
G
S
S
E
S
T
D
S
G
F
C
L
Site 6
T80
R
M
G
S
S
E
S
T
D
S
G
F
C
L
D
Site 7
S82
G
S
S
E
S
T
D
S
G
F
C
L
D
S
P
Site 8
S88
D
S
G
F
C
L
D
S
P
G
P
L
D
S
K
Site 9
S94
D
S
P
G
P
L
D
S
K
E
N
L
E
N
P
Site 10
S107
N
P
M
R
R
I
H
S
L
P
Q
K
L
L
G
Site 11
S116
P
Q
K
L
L
G
C
S
P
A
L
K
R
S
H
Site 12
S122
C
S
P
A
L
K
R
S
H
S
D
S
L
D
H
Site 13
S124
P
A
L
K
R
S
H
S
D
S
L
D
H
D
I
Site 14
S126
L
K
R
S
H
S
D
S
L
D
H
D
I
F
Q
Site 15
S156
K
K
P
V
R
P
V
S
R
G
C
L
H
S
H
Site 16
S162
V
S
R
G
C
L
H
S
H
G
L
Q
E
G
K
Site 17
T173
Q
E
G
K
D
L
F
T
Q
R
Q
N
S
A
P
Site 18
S178
L
F
T
Q
R
Q
N
S
A
P
A
R
M
L
S
Site 19
S185
S
A
P
A
R
M
L
S
S
N
E
R
D
S
S
Site 20
S186
A
P
A
R
M
L
S
S
N
E
R
D
S
S
E
Site 21
S191
L
S
S
N
E
R
D
S
S
E
P
G
N
F
I
Site 22
S192
S
S
N
E
R
D
S
S
E
P
G
N
F
I
P
Site 23
T208
F
T
P
Q
S
P
V
T
A
T
L
S
D
E
D
Site 24
S212
S
P
V
T
A
T
L
S
D
E
D
D
G
F
V
Site 25
T233
N
L
K
N
E
E
E
T
P
S
C
M
A
S
L
Site 26
S235
K
N
E
E
E
T
P
S
C
M
A
S
L
W
T
Site 27
T250
A
P
L
V
M
R
T
T
N
L
D
N
R
C
K
Site 28
S261
N
R
C
K
L
F
D
S
P
S
L
C
S
S
S
Site 29
S263
C
K
L
F
D
S
P
S
L
C
S
S
S
T
R
Site 30
S266
F
D
S
P
S
L
C
S
S
S
T
R
S
V
L
Site 31
S267
D
S
P
S
L
C
S
S
S
T
R
S
V
L
K
Site 32
S268
S
P
S
L
C
S
S
S
T
R
S
V
L
K
R
Site 33
T269
P
S
L
C
S
S
S
T
R
S
V
L
K
R
P
Site 34
S271
L
C
S
S
S
T
R
S
V
L
K
R
P
E
R
Site 35
S279
V
L
K
R
P
E
R
S
Q
E
E
S
P
P
G
Site 36
S283
P
E
R
S
Q
E
E
S
P
P
G
S
T
K
R
Site 37
S287
Q
E
E
S
P
P
G
S
T
K
R
R
K
S
M
Site 38
T288
E
E
S
P
P
G
S
T
K
R
R
K
S
M
S
Site 39
S293
G
S
T
K
R
R
K
S
M
S
G
A
S
P
K
Site 40
S295
T
K
R
R
K
S
M
S
G
A
S
P
K
E
S
Site 41
S298
R
K
S
M
S
G
A
S
P
K
E
S
T
N
P
Site 42
S302
S
G
A
S
P
K
E
S
T
N
P
E
K
A
H
Site 43
T311
N
P
E
K
A
H
E
T
L
H
Q
S
L
S
L
Site 44
S315
A
H
E
T
L
H
Q
S
L
S
L
A
S
S
P
Site 45
S317
E
T
L
H
Q
S
L
S
L
A
S
S
P
K
G
Site 46
S321
Q
S
L
S
L
A
S
S
P
K
G
T
I
E
N
Site 47
T325
L
A
S
S
P
K
G
T
I
E
N
I
L
D
N
Site 48
S342
R
D
L
I
G
D
F
S
K
G
Y
L
F
H
T
Site 49
T349
S
K
G
Y
L
F
H
T
V
A
G
K
H
Q
D
Site 50
Y359
G
K
H
Q
D
L
K
Y
I
S
P
E
I
M
A
Site 51
S361
H
Q
D
L
K
Y
I
S
P
E
I
M
A
S
V
Site 52
Y387
F
V
I
I
D
C
R
Y
P
Y
E
Y
E
G
G
Site 53
Y389
I
I
D
C
R
Y
P
Y
E
Y
E
G
G
H
I
Site 54
Y391
D
C
R
Y
P
Y
E
Y
E
G
G
H
I
K
G
Site 55
Y444
R
G
P
R
M
C
R
Y
V
R
E
R
D
R
L
Site 56
Y455
R
D
R
L
G
N
E
Y
P
K
L
H
Y
P
E
Site 57
Y460
N
E
Y
P
K
L
H
Y
P
E
L
Y
V
L
K
Site 58
Y464
K
L
H
Y
P
E
L
Y
V
L
K
G
G
Y
K
Site 59
Y470
L
Y
V
L
K
G
G
Y
K
E
F
F
M
K
C
Site 60
Y480
F
F
M
K
C
Q
S
Y
C
E
P
P
S
Y
R
Site 61
Y486
S
Y
C
E
P
P
S
Y
R
P
M
H
H
E
D
Site 62
T503
E
D
L
K
K
F
R
T
K
S
R
T
W
A
G
Site 63
S505
L
K
K
F
R
T
K
S
R
T
W
A
G
E
K
Site 64
T507
K
F
R
T
K
S
R
T
W
A
G
E
K
S
K
Site 65
S513
R
T
W
A
G
E
K
S
K
R
E
M
Y
S
R
Site 66
Y518
E
K
S
K
R
E
M
Y
S
R
L
K
K
L
_
Site 67
S519
K
S
K
R
E
M
Y
S
R
L
K
K
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation